Microbiome & Chronic Diseases

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Chemotherapy treatment {50000156}

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Chemotherapy treatment
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Shared Reference Notes

  • [1.1
    - During the chemotherapeutic treatment of Patients with acute myeloid leukemia , the number of bacteria in fecal samples was 100-fold lower than that in healthy control samples, which resulted in a lower diversity of intestinal microbiota. - Bacteroides species, Clostridium cluster XIVa, Faecalibacterium prausnitzii, and Bifidobacterium species decreased 3000–6000-fold in samples during treatment. - Daunorubicin inhibited the growth of Clostridium species, Streptococcus mitis, Bifidobacterium animalis, and Lactobacillus acidophilus but not the growth of enterococci or E. coli. - Decrease in the phylum Firmicutes distributed within Clostridium cluster XIVa, Roseburia, Lachnospiraceae, and Coprococcus and a reduction in lactobacilli and enterococci in the mucosa of mice exposed to CTX.
  • [1.2] [#Cancer, #Neutropenia
    - Transferring gut microbiota from patients with neutropenic #Fever to irradiated mice promoted the development of subsequent #Fever. - An excess of mucin-degrading #Akkermansia bacteria found in the transferred microbiomes of febrile patients, as well as in nontransplanted but irradiated or chemotherapy-treated mice that reduced their food intake, resulted in a compromised intestinal barrier in mice that could be circumvented by administration of propionate.

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