MetaBiom
Microbiome & Chronic Diseases

Evidence Based Medicine

Chemotherapy treatment {50000156}

Record Keys


Factor:
Chemotherapy treatment
Queue:[  ]

Details


Authoring date:
2020-10-19
Specification:
[  ]

Meta Information


Type:
Drug
Host:
Human
Zone:
Gut Lumen

Notes


- During the chemotherapeutic treatment of Patients with acute myeloid leukemia , the number of bacteria in fecal samples was 100-fold lower than that in healthy control samples, which resulted in a lower diversity of intestinal microbiota.
- Bacteroides species, Clostridium cluster XIVa, Faecalibacterium prausnitzii, and Bifidobacterium species decreased 3000–6000-fold in samples during treatment.
- Daunorubicin inhibited the growth of Clostridium species, Streptococcus mitis, Bifidobacterium animalis, and Lactobacillus acidophilus but not the growth of enterococci or E. coli.
- Decrease in the phylum Firmicutes distributed within Clostridium cluster XIVa, Roseburia, Lachnospiraceae, and Coprococcus and a reduction in lactobacilli and enterococci in the mucosa of mice exposed to CTX. (1)