MetaBiom
Microbiome & Chronic Diseases

Evidence Based Medicine

Oral administration of Metformin {50000154}

Record Keys


Factor:
Oral administration of Metformin
Queue:[  ]

Details


Authoring date:
2020-10-17
Specification:
[  ]

Meta Information


Type:
Drug
Host:
Mouse
Zone:
Gut Lumen

Notes


- Metformin, decreased leaky gut and inflammation in high-fat diet-fed older obese mice, by beneficially modulating the gut microbiota.
- Metformin increased goblet cell mass and mucin production in the obese older gut, thereby decreasing leaky gut and inflammation.
- Metformin treatment slightly increased Bacteroidetes in HFD-fed mice compared to their untreated HFD-fed counterparts.
- The abundance of genera belonging to S24_7, Ruminococcaceae and Lactococcus were increased, while that of Coriobacteriaceae, Lactobacillus, Dorea, SMB53, Roseburia and Veilonellaceae, and Dehalobacterium was significantly decreased in the gut of metformin-treated HFD-fed older mice compared to their HFD-fed controls.
- Similarly, the proportion of Clostridiales;g, Lachnospiraceae;g, and Ruminococcus was significantly increased while that of genus Sutterella was significantly decreased in metformin-treated LFD-fed mice compared to their LFD-fed counterparts.
- The abundance of 5-aminopantanoate_1, propionate and butyrate was increased while that of 5-aminopentanoate_2, ethanol, sarcosine, formate, creatinine, propylene glycol, and several others were decreased in metformin-treated LFD-fed older mice compared to untreated LFD-fed controls.
Similarly, the abundance of taurine, butyrate, total bile acids_1, propionate, and leucine was increased while that of creatinine, sarcosine, glutamate, pyruvate, and formate was significantly decreased in the feces of metformin-treated HFD-fed older mice compared to their untreated HFD-fed counterparts
. Metformin caused highest increase in butyrate and taurine and highest decrease in creatinine and sarcosine abundance in the gut of older mice .(1)