MetaBiom
Microbiome & Chronic Diseases

Evidence Based Medicine

Inositol triphosphate {50000139}

Record Keys


Factor:
Inositol triphosphate
Queue:[  ]

Details


Authoring date:
2020-09-01
Specification:
[  ]

Links


Meta Information


Type:
Microbial
Host:[  ]
Zone:[  ]

Notes


- Inositol triphosphate (IP3) activates HDAC enzymes.
- One enzyme that helps direct cell proliferation and tissue repair of the gut barrier is histone deacetylase 3 (HDAC3). HDAC3 is an epigenetic regulator of gene expression and prevents transcription of certain genes when activated. Therefore, HDAC3 plays an important role in maintenance of the intestinal barrier which is constantly being renewed.

-IP3 signaling may be the major factor stimulating HDAC3 activity. IP3 is produced by microbial conversion of phosphate in the human diet, which is often present as phytate in many plant-based foods such as wheat and oats. Phytate requires processing by microbial phytase before it can be absorbed and utilized. (1)