MetaBiom
Microbiome & Chronic Diseases

Evidence Based Medicine

High-fat diet {50000130}

Record Keys


Factor:
High-fat diet
Queue:[  ]

Details


Initialisation date:
2019-08-17
Specification:
[  ]

Meta Information


Type:
Diet
Host:
Mouse
Zone:
Gut Lumen

Notes


[  ]

Shared Notes


  • [1.1
    - A high-fat diet promotes an increase of Firmicutes and relative reduction of Bacteroidetes, which in turn alters our energy metabolism by promoting more effective caloric intake and, ultimately, weight gain and obesity.
  • [1.3
    - The population of Akkermansia in the gut is negatively modulated by the fat content of the consumed diet.
  • [1.2
    - High-fat diet and obesity are associated with increased Firmicutes and decreased Bacteroidetes
  • [1.4
    - Bacteroidetes has a substrate preference for certain fats.
  • [1.5
    - The abundance of other bacterial families decreased on a high-fat diet including Bifidobacteriacaea and Bacteriodacaea, which are commonly associated with leanness.
  • [1.6
    - Ruminococcaceae (order Clostridiales) that are prominent producers of butyrate, decreased in relative abundance with a high-fat diet.
    - This decrease is particularly significant because Ruminococcaceae, making up ≈20% of gut bacteria in chow-fed OSA rats, decreased to ≈10% in high-fat OSA rats . Members of the order Clostridiales, other than Ruminococcaceae, also significantly decreased with high-fat diet.

Common References