MetaBiom
Microbiome & Chronic Diseases

Evidence Based Medicine

Non-nutritive Sweeteners {50000125}

Record Keys


Factor:
Non-nutritive Sweeteners
Queue:[  ]

Details


Authoring date:
2019-06-23
Specification:

Sugar substitute

Links


Meta Information


Type:
Diet
Host:
Mouse
Zone:
Gut Lumen

Notes


- Microbiome profiling confirmed a significant increase in firmicutes and a striking decrease of Akkermansia muciniphila. Similar microbiome alterations in humans have been linked to metabolic disease and obesity.
- Akkermansia muciniphila is transmitted but does not consistently colonize pups born to NNS-exposed mothers.
Akkermansia muciniphila, depleted in NNS pups, is a beneficial bacterium associated with a young and lean metabolism, inversely correlated with fat mass gain, type 1 diabetes and Inflammatory bowel syndrome .
- pre- and post-natal exposure to sucralose and acesulfame-K via maternal ingestion causes marked metabolic and microbiome alterations in the pups (1)