MetaBiom
Microbiome & Chronic Diseases

Evidence Based Medicine
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Antibiotic Therapy {50000120}

Record Keys


Factor:
Antibiotic Therapy
Queue:[  ]

Details


Initialisation date:
2020-09-06
Specification:
[  ]

Links


Meta Information


Type:
Antibiotic, Drug
Host:[  ]
Zone:[  ]

Notes


- In the urinary tract, we propose that antibiotics lead to a loss of health-protective Lactobacillus and a subsequent re-colonization by stone-promoting Enterobacteriaceae

Shared Notes


  • [1.3
    - Recent exposure to antibiotics is the best predictor of decreased Prevotella.
  • [1.4
    - Autism patients who have had their intestinal microbiota remodeled through the administration of antibiotics or bacterial transfer therapy in the intestine, presented with attenuated symptoms of ASD
  • [1.2
    - While antibiotics likely affect the microbiome, our results suggest that antibiotic influence alone cannot explain the distinctive microbiomes of PTLDS patients.
  • [1.5
    - Overuse of antibiotics might reduce the plasma level of lignan enterolactone; therefore, it might directly affect the microbiome populations and increase the BC risk
  • - Commensal microbiota is normalized a few weeks after antibiotic treatment secession.
  • [1.6
    - Early antibiotic exposure in animal models has shown that reductions in the population size of specific microbiota, such as Lactobacillus, Allobaculum, Rikenellaceae, and Candidatus Arthromitus, are related to subsequent adiposity.
  • [1.7
    - Bacteroidota, are well-adapted to their human host and can be extremely persistent across individuals, families, and geographic areas. As their human host grow up, these bacteria are able to persist in the gut by switching to different nutrition sources. The researchers named these bacteria “tenacious”.
    However, tenacious bacteria are the most likely to be lost from the microbiota after antibiotic use
  • [1.10
    - Antibiotic treatments have been shown to decrease the effectiveness of anti-PD-L1 antibody therapy
  • [1.11
    - Antibiotic-induced perturbation of the gut microbiota > increases tumor progression in multiple BrCa mouse models > increased number of cells with a stromal signature in tumors > increased abundance of mast cells in the tumor stromal regions.
    - Re-supplementation of antibiotic-treated mice with Faecalibaculum rodentium > restored tumor growth to control levels
    - Mast cell stabilizer, cromolyn > decreases tumor growth only in antibiotic treated animals

Common References