MetaBiom
Microbiome & Chronic Diseases

Evidence Based Medicine

Consumption of Inulin-Type Fructans (ITF) {50000111}

Record Keys


Factor:
Consumption of Inulin-Type Fructans (ITF)
Queue:[  ]

Details


Authoring date:
2019-02-24
Specification:
[  ]

Meta Information


Type:
Prebiotic
Host:
Human
Zone:
Gut Lumen

Notes


- Prebiotics such as inulin-type fructans (ITF) and arabinoxylan-oligosaccharides (AXOS) can be consumed to increase the number of bifidobacteria in the colon. (1)

- Except for a bifidogenic effect, ITF and AXOS also have shown to cause a butyrogenic effect in the human colon, i.e., an enhancement of colon butyrate production. Butyrate is an essential metabolite in the human colon, as it is the preferred energy source for the colon epithelial cells, contributes to the maintenance of the gut barrier functions, and has immunomodulatory and anti-inflammatory properties. (1)

- The butyrogenic effects of ITF and AXOS are the result of cross-feeding interactions between bifidobacteria and butyrate-producing colon bacteria, such as Faecalibacterium prausnitzii (clostridial cluster IV) and Anaerostipes, Eubacterium, and Roseburia species (clostridial cluster XIVa). (1)