MetaBiom
Microbiome & Chronic Diseases

Evidence Based Medicine

Chronic kidney disease {40000186}

Record Keys


Definition:
Chronic kidney disease
Class:[  ]

Details


Other Terms:
CKD
Authoring date:
2020-10-13

Meta Information


ICD:[  ]
MedDra ID:
10064848
MedDra Level:
pt

Notes


[  ]

Shared Notes


  • [1.11
    - In chronic kidney disease (CKD), the “healthy” microbiota structure is disrupted, and intestinal microbes produce large quantities of uremic solutes responsible for renal damage; on the other hand, the uremic state, fueled by reduced renal clearance, causes shifts in microbial metabolism and composition, hence creating a vicious cycle in which dysbiosis and renal dysfunction are progressively worsened.
  • [1.12
    - Saccharibacteria (per 1-SD higher in the log-transformed abundance) could potentially decrease the concentration of serum creatinine and increase the estimated glomerular filtration rate which might help improve renal function.

Common References