Microbiome & Chronic Diseases

Evidence Based Medicine

Inflammatory bowel disease {40000180}

Record Keys

Inflammatory bowel disease
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ICD:[  ]
Gastroenterologic, Rheumatologic
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Shared Notes

  • [1.13
    - Seven bacterial species correlated with expression levels of Th17 effector cytokines, IL-17A and IL-17F.
    - The seven associated species include Ruminococcus gnavus, Escherichia coli, Lachnospiraceae bacterium, Clostridium hathewayi, Bacteroides faecis, Bacteroides vulgatus, and Akkermansia muciniphila. All of the species were positively associated with IL-17A/ IL-17F except Akkermansia muciniphila, suggesting these species are proinflammatory, while Akkermansia muciniphila is anti-inflammatory.
  • [1.14
    - Ruminococcus torques and Ruminococcus gnavus, two prominent species in IBD19, were also differentially abundant in dysbiotic CD and UC, respectively as well as showing differences in abundance, including Clostridium hathewayi, Clostridium bolteae, and R. gnavus. All had significantly increased expression during dysbiosis, and thus their roles in IBD may be more pronounced than suggested solely by their differences in genomic abundance.
    - The reduction in butyrate in particular is consistent with the previously observed depletion of butyrate producers such as F. prausnitzii and R. hominis.

Common References