MetaBiom
Microbiome & Chronic Diseases

Evidence Based Medicine

Esophageal cancer ⇒ Cancer {40000175}

Record Keys


Definition:
Esophageal cancer
Class:

Details


Other Terms:[  ]
Authoring date:
2020-09-01

Links


Meta Information


ICD:[  ]
Category:
Gastroenterologic, Oncologic
MedDra ID:
10030155
MedDra Level:
4

Notes


- P. gingivalis was detected immunohistochemically in 61 % of cancerous tissues, 12 % of adjacent tissues and was undetected in normal esophageal mucosa. A similar distribution of lysine-specific gingipain, a catalytic endoprotease uniquely secreted by P. gingivalis, and P. gingivalis 16S rDNA was also observed.
- P. gingivalis infection positively associated with multiple clinicopathologic characteristics, including differentiation status, metastasis, and overall survival rate. (1)

Shared Notes


  • [1.3
    - The presence of oral P. gingivalis and T. forsythia associate with an increased risk of esophageal cancer.
    - P. gingivalis and T. forsythia are included in signaling pathways responsible for cancer development.
    - T. forsythia may induce pro-inflammatory cytokines such as IL-1β and IL-6 by CD4 + T helper cells and TNF-α.
    - gingipain K produced by P. gingivalis, affects hosts immune system by degradation of immunoglobulins and complement system.

Common References