MetaBiom
Microbiome & Chronic Diseases

Evidence Based Medicine

Amyotrophic lateral sclerosis {40000171}

Record Keys


Definition:
Amyotrophic lateral sclerosis
Class:[  ]

Details


Other Terms:
ALS
Authoring date:
2019-08-25

Links


Meta Information


ICD:[  ]
Category:
Neurologic
MedDra ID:
10002026
MedDra Level:
4

Notes


[  ]

Shared Notes


  • [1.6
    - Nicotinamide produced by the Akkermansia muciniphila bacteria slowed disease progression and prolonged survival in an ALS mouse model.
    - Nicotinamide benefits may be linked with improvements in mitochondria function.
    - Nicotinamide and its intermediary molecules significantly reduced in ALS.
    - Nicotinamide levels were decreased in the brains of ALS patients; this reduction was associated with enhanced muscle weakness.
    - Ruminococcus torques and Parabacteroides distasonis worsened ALS symptoms (1)

Common References