MetaBiom
Microbiome & Chronic Diseases

Evidence Based Medicine

Polycystic ovary syndrome {40000170}

Record Keys


Definition:
Polycystic ovary syndrome
Class:[  ]

Details


Other Terms:
PCOS
Authoring date:
2019-08-18

Links


Meta Information


ICD:[  ]
Category:
Endocrinologic, Gyneocologic
MedDra ID:
10036049
MedDra Level:
4

Notes


- Women with PCOS has a homogenous gut microbiome and an enrichment in Bacteroides vulgatus, along with an increase in genes that encode bile salt hydrolases.
- Stool transplantation from women with PCOS or the administration of B. vulgatus by oral gavage induced insulin resistance, a disrupted estrous cycle and ovarian morphology, altered bile acid metabolism, reduced interleukin-22 secretion and infertility and changes in testosterone and luteinizing hormone levels in recipient mice.
- Decrease in glycodeoxycholic acid and subsequent decreased IL-22 also documented in women with PCOS. glycodeoxycholic acid induced intestinal group 3 innate lymphoid cell IL-22 secretion through GATA binding protein 3, and IL-22 in turn improved the PCOS phenotype. This finding is consistent with the reduced levels of IL-22 in individuals with PCOS. (1)

Common References