MetaBiom
Microbiome & Chronic Diseases

Evidence Based Medicine

Rheumatoid Arthritis {40000107}

Record Keys


Definition:
Rheumatoid Arthritis
Class:[  ]

Details


Other Terms:
RA
Authoring date:
2019-06-16

Links


Meta Information


ICD:[  ]
Category:
Musculoskeletal, Rheumatologic, Immunologic
MedDra ID:
10039073
MedDra Level:
4

Notes


- ACPA generation may be associated with larger populations of Prevotellaceae in both oral and intestinal microbiomes. In response to such altered microbial flora, certain predisposed individuals may develop auto-inflammatory disease, through mechanisms that may include the generation of cyclic citrullinated peptides or Th17 cell activation in the intestinal mucosa. (4)

Shared Notes


  • [1.22
    - Patients with RA showed an altered metabolic capacity for transporting zinc and copper. The study authors suggest that these alterations may significantly influence the perpetuations of the autoimmunity of RA.
    - Porphyromonas gingivalis (discussed within “Periodontal Microbiome and ACPA” section), Proteus mirabilis, Mycobacterium tuberculosis, and Mycoplasma spp are associated with an increased risk of RA development.
  • [1.23
    - When compared with controls, participants with RA had increased levels of the Collinsella aerofaciens species and enterococcus genera. Likewise, an increase of arginine deaminase activity was observed, which belonged, in approximately 90%, to the RA genes of the genus Collinsela.
  • [1.24
    - Porphyromonas gingivalis is a leading pathogen in chronic periodontitis, a disease process involving progressive destruction of the tissues that support the teeth. Recently, the organism has been reported to produce a unique bacterial enzyme, P. gingivalis peptidyl-arginine deiminase (PPAD), which has the ability to convert arginine residues in proteins to citrulline. Protein citrullination alters protein structure and function; hence, PPAD may be involved in deregulation of the host signalling network and immune evasion.
  • [1.25
    - Significantly lower abundances of Coprococcus in CD, Dialister in MS, and Roseburia in RA.
  • [1.26
    - Aggregatibacter actinomycetemcomitans (Aa) is a Gram-negative coccobacillus recognized as a pathogen in periodontitis and infective endocarditis. By producing a toxin (leukotoxin A, LtxA) that triggers global hypercitrullination in neutrophils, Aa has been recently linked to rheumatoid arthritis.
    - Aa has been proposed as a link between periodontitis and autoimmunity in rheumatoid arthritis (RA) due to its ability to induce citrullinated autoantigens targeted by anti-citrullinated protein antibodies (ACPAs).

Common References