Symptom ⇒ Pain {40000658} Record Keys Type:Symptom Parent:[ ] Definition:Pain Details Initialisation date:[ ] Other Terms:[ ] Meta Information MedDra ID:[ ] MedDra Level:[ ] ICD:[ ] Category:[ ] Zone:[ ] Mechanism:[ ] Notes: [ ]Shared Reference Notes [1.1] - mice that lacked these pain-mediating neurons > mucus thickness was significantly decreased compared with that of the control group > nociceptor neurons might be involved in mucus production > activate the nociceptor neurons, which induced dramatically increased mucus thickness. - generally blocking pain signaling with opioids or other drugs could have unforeseen consequences on gut barrier function or mucus production that we should be cautious about. - Pain signaling > neurons used a signal called #CGRP to communicate with goblet cells > produce mucus. - Gut microbes are one factor that causes neurons to produce #CGRP and induce goblet cells to produce mucus. - mice that lacked either nociceptor neurons or #CGRP were more susceptible to colitis. References Notes[ ]
