Microbiome & Chronic Diseases

Evidence Based Medicine

Melanoma {40000152}

Record Keys

Class:[  ]


Other Terms:
Malignant melanoma
Authoring date:


Meta Information

ICD:[  ]
Dermatology, Oncologic
MedDra ID:[  ]
MedDra Level:[  ]


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Shared Notes

  • [1.1
    - Patients with an unfavorable gut microbiome (e.g., low diversity and high relative abundance of Bacteroidales) have impaired systemic and anti-tumor immune responses mediated by limited intratumoral lymphoid and myeloid infiltration and weakened antigen presentation capacity.
    - The gut microbiome may modulate responses to anti PD-1 immunotherapy in melanoma patients.
    - Patients with a favorable gut microbiome (e.g., high diversity and abundance of Ruminococcaceae/Faecalibacterium) have enhanced systemic and anti-tumor immune responses mediated by increased antigen presentation, and improved effector T cell function in the periphery and the tumor microenvironment.
  • [1.2
    -Bifidobacterium emerged as strongly associated with T cell response, and consistently, oral administration of a cocktail of Bifidobacterium species combined with an anti-PD-L1 antibody nearly abolished the melanoma growth.
    - Bifidobacterium longum, Collinsella aerofaciens, and Enterococcus faecium was associated with anti-PD1 efficacy in metastatic melanoma patients. (2)

Common References