Disease ⇒ Selective immunoglobin A (IgA) deficiency {40000620} Record Keys Type:Disease Parent:[ ] Definition:Selective immunoglobin A (IgA) deficiency Details Initialisation date:[ ] Other Terms:[ ] Meta Information MedDra ID:[ ] MedDra Level:[ ] ICD:[ ] Category:[ ] Zone:[ ] Mechanism:[ ] Notes: [ ]Shared Reference Notes [1.1] - In IgA-deficiency > translocation of specific bacterial taxa associated with elevated levels of systemic IgG targeting fecal microbiota. - Associated features of immune system dysregulation in IgA-deficient mice and humans included elevated levels of inflammatory cytokines, enhanced follicular CD4 T helper cell frequency and activation, and an altered CD8 T cell activation state. - In children and adolescents who lack both systemic and fecal IgA, bacteria were more likely to breach the gut barrier and travel to lymph nodes in the abdomen.References Notes[ ]
