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Microbiome & Chronic Diseases

Evidence Based Medicine
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Dementia {40000512}

Record Keys


Definition:
Dementia
Class:[  ]

Details


Other Terms:
ccyc
Initialisation date:
2020-10-23

Meta Information


ICD:[  ]
Category:
Neurology
MedDra ID:[  ]
MedDra Level:[  ]

Notes


[  ]

Shared Notes


  • [1.2
    - Middle‐aged and old patients with vitiligo are more likely to develop dementia compared with those without vitiligo.
  • [1.3
    - Low B-12 not only causes central nervous system (CNS) damage by decreasing availability of methyl groups, but also allows accumulation of homocysteine, which appears to be toxic to nerve cells and blocks N-methyl-dasparate receptors.
    - It is also important to remember that for B-12 by itself to be functional, it needs to be converted to glutathionyl cobalamin, which requires glutathione for its synthesis. Oxidative stress can tie up glutathione and contribute further to lack of B-12 function.
  • [1.1
    - High equol producers had >50% lower WML% than non-producers.
    - Equol‐producing status (non‐producers, low and high) was significantly inversely associated with WML%. (1)

Common References