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- Differences in the fungal community were more strongly associated with asthma risk than bacterial dysbiosis.
- Overrepresentation of total fungal sequences and an expansion of the yeast Issatchenkia orientalis in children who later developed symptoms
- Increased maternal dietary microbiome-accessible fiber and SCFA exposure during pregnancy, may result in a reduced incidence of asthma in offspring which persists into adulthood.
- An association exists between there is an areduced dietary fiber intake and reduced serum acetate levels in pregnant women.
- The serum acetate levels that were lower than the median, is related to increased frequency of coughing/wheezing during the child’s first year of life.
- During pregnancy, SCFA (such as acetate) can cross the placenta and affect the expression of fetal lung genes, such as NPPA, which encodes ANP (a molecule related to epithelial biology and immune regulation).
- Severe respiratory viral infection with respiratory syncytial virus (RSV) and rhinovirus (RV) is associated with increased risk of developing asthma, and as such, these viruses are considered asthmagenic.
- Mice nasally exposed to two distinct strains of the commensal bacterial species Lactobacillus rhamnosus (LR05 and LR06) were protected against subsequent RSV infection.
- Protection was associated with increased levels of IFN-β, IFN-γ, IL-6, and TNF-α in both BAL and serum samples, which contributed to viral clearance.
- [1.1] Airway microbiome in different inflammatory phenotypes of asthma: a cross-sectional study in northeast China   [International Journal of Medical Sciences] [Journal]
- [1.2] Aerodigestive dysbiosis in children with chronic cough   [Pediatric Pulmonology] [Journal]
- [1.3] Lower airway microbiota and mycobiota in children with sever asthma   [Journal of Allergy and Clinical Immunology] [Journal]
- [1.4] Shifts in Lachnospira and Clostridium sp. in the 3-month stool microbiome are associated with preschool age asthma   [Clinical Science] [Journal]
- [1.5] Airway microbiota and bronchial hyperresponsiveness in patients with suboptimally controlled asthma   [Journal of Allergy and Clinical Immunology] [Journal]
- [1.6] Sputum microbiota in severe asthma patients: relationship to eosinophilic inflammation   [Respiratory Medicine] [Journal]
- [1.7] Fecal microbiota profile in atopic asthmatic adult patients   [European Annals of Allergy and Clinical Immunology] [Journal]
- [1.8] Asthma-associated differences in microbial composition of induced sputum   [Journal of Allergy and Clinical Immunology] [Journal]
- [1.9] Comparison of oropharyngeal microbiota from children with asthma and cystic fibrosis   [Mediators of Inflammation] [Journal]
- [1.10] The infant airway microbiome in health and disease impacts later asthma development   [Cell Host Microbe] [Journal]
- [1.11] The airway microbiome in patients with severe asthma: associations with disease features and severity   [Journal of Allergy and Clinical Immunology] [Journal]
- [1.12] Microbial communities in the upper respiratory tract of patients with asthma and chronic obstructive pulmonary disease.   [PLOS ONE] [Journal]
- [1.13] Bacterial microbiota of the upper respiratory tract and childhood asthma   [The Journal of Allergy and Clinical Immunology] [Journal]
- [1.14] Different upper airway microbiome and their functional genes associated with asthma in young adults and elderly individuals   [Allergy] [Journal]
- [1.15] Bacterial salivary microbiome associates with asthma among african american children and young adults   [Pediatric Pulmonology] [Journal]
- [1.16] A low abundance of Bifidobacterium but not Lactobacillus in the feces of Chinese children with wheezing diseases   [Medicine] [Journal]
- [1.17] Early infancy microbial and metabolic alterations affect risk of childhood asthma   [Science translational medicine] [Journal]
- [1.18] Intestinal fungi are causally implicated in microbiome assembly and immune development in mice  [Review]  [Nature communications] [Journal]
- [1.19] Maternal Vegetable and Fruit Consumption during Pregnancy and Its Effects on Infant Gut Microbiome  [Clinical study]  [Nutrients] [Journal]
- [1.20] Microbiota in Allergy and Asthma and the Emerging Relationship with the Gut Microbiome  [Research]  [Cell Host & Microbe] [Journal]