MetaBiom
Microbiome & Chronic Diseases

Evidence Based Medicine
Sign in

Type 2 diabetes {40000105}

Record Keys


Definition:
Type 2 diabetes
Class:[  ]

Details


Other Terms:
T2D, adult-onset diabetes
Initialisation date:
2020-09-06

Links


Meta Information


ICD:[  ]
Category:[  ]
MedDra ID:
10067585
MedDra Level:
pt

Notes


- The microbiome literature on T2D appears chaotic and concerns have been raised about variability of the results. Different taxa are reported to be associated with T2D in different studies. Furthermore, a recent large study observed that different microbes were found associated with the same metabolic outcomes in different geographical areas.


- Enterobacter cloacae B29 induced obesity and insulin resistance in germ-free mice. (3)

- PPI use is associated with reduced diversity of gut microbiome and consistent changes in the microbiota phenotype. (5)
- GIPR postbiotic agonist/antagonist may caus/prevent DM

Shared Notes


  • [1.35
    - Diabetes taking metformin had higher relative abundance of Akkermansia muciniphila, a microbiota known for mucin degradation, and several gut microbiota known for production of SCFAs, including Butyrivibrio, Bifidobacterium bifidum, Megasphaera, and an operational taxonomic unit of Prevotella.
  • [1.36
    - Duodenal hypercontractility observed during T2D leads to the genesis of aberrant signalling from the afferent nerves to the hypothalamus, contributing to systemic insulin resistance
    - Enteric NO has the capacity to decrease duodenal contractions and restore the gut-brain axis, subsequently improving insulin sensitivity
    - Prebiotic treatment (oligofructose) decreases duodenal hypercontractility by modulating ENS activity and an increase in the levels of an intestinal lipid, 12-hydroxyeicosatetraenoic acid (12-HETE).
    - The mechanism of prebiotic action implies the presence of an enkephalin/mu-opioid receptor and proliferator-activated receptor γ signalling and a bioactive lipid, 12S-hydroxyeicosatetraenoic acid.
  • [1.32
    - Synbiotic yogurt-fed mice demonstrated lower fasting blood glucose (FBG) levels.
    - The blood glucose rise during the meal tolerance test (MTT) is lower in the synbiotic yogurt-fed mice
    - Insulin sensitivit in not impacted by Synbiotic yogurt-fed in mice.
    - the abundances of fecal Proteobacteria and Enterobacteriacae correlate positively with FBG levels which increase the progression of diabetes in mice.
  • [1.37
    - Agonism of GIP receptor (GIPR) have glycemic effect.
  • [1.38
    - There is a significant correlation between gut microbiota dysbiosis and an elevated level of interleukin 6 (IL-6) in plasma samples of patients with type 2 diabetes (T2D)
  • [1.39
    - The feeding of the synbiotic yogurt significantly reduced the development of hyperglycemia (diabetes) in response to high-fat diet feeding and streptozotocin compared to milk-fed controls.
  • [1.40
    - The commonly used diabetes treatment Metformin increase Akkermansia spp. abundance, and to significantly improve glucose metabolism in high-fat diet fed mice while also increasing the number of mucin-producing goblet cells.
  • [1.41
    - Gut-targeted delayed-release NA but not NAM produced a significant increase in the abundance of Bacteroidetes.
    - In the absence of systemic side effects, these favorable microbiome changes induced by microencapsulated delayed-release NA were associated with an improvement of biomarkers for systemic insulin sensitivity and metabolic inflammation.
  • [1.42
    - Genera of Bifidobacterium, Bacteroides, Faecalibacterium, Akkermansia and Roseburia were negatively associated with T2D, while the genera of Ruminococcus, Fusobacterium, and Blautia were positively associated with T2D.
  • - Bifidobacterium appears to be the most consistently supported by the literature genus containing microbes potentially protective against T2D
  • - there is a negative association between specific species such as B. adolescentis, B. bifidum, B. pseudocatenulatum, B. longum, B. dentium and disease in patients treated with metformin or after undergoing gastric bypass surgery
  • [1.43
    - In a mouse model oral administration of Akkermansia activated toll-like receptor 2, increased the expression of epithelial tight-junction proteins, and reversed high-fat diet-induced insulin resistance
    - Akkermansia was the only genus that was underrepresented in patients with elevated HbA1c
  • - Anaerostipes is positively associated with type 2 diabetes. Similarly, in studies of type 1 diabetes and gestational diabetes, Parabacteroides was elevated compared to healthy controls.
  • - Parabacteroides is positively associated with diabetes.
  • [1.44
    - High fiber diet > Prevotella copri > improve glucose and insulin tolerance.
  • [1.34
    - Four G-protein coupled receptors (GPCRs) for SCFAs have been identified: GPR41 (free fatty acid receptor 3), GPR43 (free fatty acid receptor 2), GPR109a, and olfactory receptor 78.
    - Of the 4 receptors, the 2 most directly implicated in T2DM are GPR41 and GPR43.
    - GPR41 recognizes all 3 SCFAs but is activated 10-fold less by acetate and is reported to be expressed in adipose tissue, the gut by intestinal L-cells, the nervous system, and the kidney.
    - GPR41 resulted in increased gut motility via reduced peptide YY (PYY) secretion, which resulted in decreased intestinal absorption of nutrients, implicating a role in food consumption.
    - GPR41 activation stimulate energy expenditure, thereby having a protective effect against T2DM onset.
    In the kidney, GPR41 seems to play a role in decreasing blood pressure, which could play a protective role againstT2DM-mediated kidney damage in later disease stages.
    - Treatment with SCFAs in both rodent models and humans improves T2DM phenotypes
  • - In diabetic mice, the administration of a synthetic FXR agonist markedly reduced plasma glucose, triglycerides, free fatty acids, and cholesterol as well as hepatic steatosis.
    - Conversely, intestine-specific knockout of FXR in mice was shown to reduce insulin resistance and hepatic triglyceride accumulation
  • - TGR5, unlike the nuclear receptors discussed above, is a GPCR, expressed by digestive, immune, and adipose tissues where it is preferentially activated by LCA and DCA.
    - In the gut, TGR5 activation leads to secretion of GLP-1 and PYY, thereby having beneficial effects on insulin secretion and satiety.
    - TGR5 knockout in macrophages and myeloid-lineage cells was found to exacerbate adipose tissue inflammation and insulin resistance, suggesting a protective role in T2DM pathogenesis
  • - Among obese individuals with at least 1 comorbidity the production of indole, IPA, indole 3-acetic acid, and indole 3-carboxaldehyde is decreased versus lean individuals, suggesting that a change in meta-organismal tryptophan metabolism may occur prior to T2DM onset and thus may contribute to its development.
  • - The microbial product of histidine metabolism, imidazole propionate (ImP), was recently shown to be directly involved in insulin resistance.
    - Exogenous ImP showed worsened glucose tolerance, increased gluconeogenic enzyme expression, increased S6 kinase phosphorylation, and impaired insulin signaling in multiple tissues on a normal chow diet. In vitro ImP also impaired insulin-stimulated phosphorylation of protein kinase B.
    - ImP activates mTORC1.
  • - TMA and subsequent conversion to TMAO by host FMO3 is related to T2DM pathogenesis and comorbidities.
    - Mice with selective hepatic insulin resistance have elevated levels of circulating TMAO.
    - Dietary supplementation with TMAO can exacerbate glucose intolerance in high-fat–fed mice.
    - High concentrations TMAO directly binds to and activates PERK, a key effector of the unfolded protein response in the liver, promoting hyperglycemia and metabolic dysfunction
  • [1.45
    - Lachnospira contribute to diabetes in obese mice and is enriched in obese children
  • [1.46
    - Individuals with T2D have lower gut microbiome alpha diversity compared with healthy controls and they also show impaired SCFA butyrate production,12 modifications in incretin secretion, reducing intestinal permeability leading to metabolic endotoxemia (increased LPS in blood) that is linked to increasing metabolic inflammation and insulin resistance induced by high-fat diet.
  • [1.55
    - Lactobacillus > positively correlated with fasting glucose and HbA1c levels > increased insulin resistance.
  • - Clostridium > negative correlation with with fasting glucose and HbA1c levels > decreased insulin resistance.
  • [1.57
    - TIIDM > low levels of Roseburia inulinivorans, Eubacterium eligens , and Bacteroides vulgatus,
    - All these bacteria > increase following the “good” diet and > decrease following the “bad” diet.
  • - Low levels of Anaerostipes > improved glucose tolerance and reduced plasma triglyceride levels in mice
  • [1.58
    - Prob+BBR superior to BBR or Prob alone in improving postprandial total cholesterol (pTC) and low-density lipoprotein cholesterol (pLDLc) levels with decrement of multiple species of postprandial lipidomic metabolites after 3 months follow-up.
    - This effect was linked to the changes of fecal Bifidobacterium breve level responding to BBR alone or Prob+BBR treatment.
    - Four fadD genes encoding long-chain acyl-CoA synthetase > identified in the genome of this B. breve strain, and transcriptionally activated by BBR.
    - The activation of fadD by BBR could enhance FFA import and mobilization in B. breve and diliminish the intraluminal lipids for absorption to mediate the effect of Prob+BBR on PL.
  • [1.59
    - In patients with pre-diabetes and hypovitaminosis D : high dose vitamin D > improves insulin sensitivity and decreases risk of progression toward diabetes.
  • [1.60
    - gut microbiota, especially Faecalibacterium, Predict postprandial glucose response (PPGR) after eating potatoes.
  • [1.61
    - Probiotic supplements do not induce clinically significant reductions in HbA1c levels, but lead to marginally clinically significant reductions in fasting glucose and fasting insulin levels in patients with type 2 diabetes.
    - Compared with single-strain and low-dose probiotics, multi-strain and high-dose probiotics have a greater beneficial effect on glycemic homeostasis.
  • [1.28
    - Black women, regardless of insulin sensitivity > greater relative abundance of the phylum Actinobacteria, compared to White women.
    - Black women with insulin resistance > four fold higher Verrucomicrobia abundance than White women.
  • [1.62
    - Akkermansia muciniphila is a mucin degraders, an important role in the preservation of the integrity of the gut mucus layer, thus
    limiting the risk of systemic inflammation.
    - Dietary polyphenols such as anthocyanins (ACNs) and proanthocyanidins (PACs) protect against metabolic syndrome.
    - Supplementation of high-fat diets with ACNs or PACs has been shown to suppress the expression of genes involved in fatty acid and triacylglycerol synthesis, the regulation of lipogenesis and cholesterol biosynthesis, and the assembly of very low density
    lipoproteins.
    - ACNs and PACs have also been argued to stem the development of insulin resistance by increasing insulin signaling, glycogen accumulation and adiponectin secretion in the presence of free fatty acids.
    A. muciniphila abundance has been linked to reduced weight gain, adiposity, insulin resistance, and/or inflammatory markers in many contexts, including during pregnancy.
  • [1.63
    - Faecalibacterium prausnitzii, an indicator of inflammation, shows a decreased abundance in diabetes and obese persons.


[Overlap other Diseases]

DiseaseOverlapCommon increased OrganismCommon decreased Organism
Type 2 diabetes 1.0000 118 (1.00) : Acidaminococcus | Acinetobacter | Actinobacteria | Actinomyces | Actinomyces georgiae | Actinomyces israelii | Actinomyces naeslundii | Actinomyces viscosus | Actinotalea | Aggregatibacter actinomycetemcomitans | Akkermansia muciniphila | Alishewanella | Alistipes | Bacteroides | Bacteroides caccae | Bacteroides coprophilus | Bacteroides finegoldii | Bacteroides intestinalis | Bifidobacteriaceae | Bifidobacterium | Brevibacterium | Burkholderia | Campylobacter gracilis | Campylobacter rectus | Campylobacter showae | Capnocytophaga ochracea | Capnocytophaga sputigena | Chryseobacterium | Clostridium boltae | Clostridium bolteae | Clostridium clostridioforme | Clostridium hathewayi | Clostridium ramosum | Clostridium symbiosum | Collinsella intestinalis | Comamonas | Corynebacterium | Corynebacterium matruchotii | Deinococcus | Delftia | Dermacoccus | Desulfovibrio piger | Dialister | Dorea | Eggerthella | Eggerthella lenta | Enterobacter cloacae B29 | Enterococcus | Epstein-Barr virus | Escherichia | Escherich 91 (1.00) : Acinetobacter | Actinomycetales | Adlercreutzia | Aggregatibacter | Akkermansia | Akkermansia muciniphila | Anaerostipes | Aquabacterium | Arcanobacterium | Arcobacter | Atopobium | Bacteriodes uniformis | Bacteroides ovatus | Bacteroides vulgatus | Bifidobacterium | Bifidobacterium adolescentis | Bilophila | Blautia coccoides | Bradyrhizobiaceae | Butyricimonas | Campylobacter | Capnocytophaga ochracea | Cardiobacterium valvarum | Cellulosilyticum ruminicola | Clostridium bartletti | Clostridium beijerinckii | Clostridium botulinum | Clostridium butyricum | Clostridium leptum | Clostridium paraputrificum | Clostridium thermocellum | Collinsella | Coprococcus | Corynebacterium matruchotii | Desulfurispirillum indicum | Dialister invisus | Dorea | Epulopiscium | Erysipelotrichaceae | Eubacterium | Eubacterium rectale | Faecalibacterium | Faecalibacterium prausnitzii | Filifactor | Fusobacterium | Gallicola | Haemophilus | Haemophilus parainfluenzae | Klebsiella | Kocuria | Lachnobacterium | Lachnospira | Lach
Crohn's disease 0.0907 36 (0.09) : Acidaminococcus | Acinetobacter | Actinomyces | Bacteroides caccae | Bifidobacterium | Burkholderia | Campylobacter gracilis | Clostridium boltae | Clostridium ramosum | Eggerthella | Enterococcus | Escherichia | Escherichia coli | Finegoldia | Fusobacterium | Fusobacterium nucleatum | Haemophilus | Klebsiella | Lachnospiraceae | Lactobacillus | Parabacteroides distasonis | Parvimonas micra | Peptostreptococcus | Prevotella | Pseudomonas | Ruminococcus gnavus | Shigella | Sphingomonas | Staphylococcus | Stenotrophomonas | Streptococcus | Streptococcus anginosus | Streptococcus intermedius | Streptococcus mutans | Streptococcus salivarius | Veillonella parvula 38 (0.10) : Adlercreutzia | Akkermansia | Akkermansia muciniphila | Anaerostipes | Bacteriodes uniformis | Bacteroides vulgatus | Bifidobacterium | Bifidobacterium adolescentis | Bilophila | Blautia coccoides | Butyricimonas | Clostridium leptum | Collinsella | Coprococcus | Dialister invisus | Dorea | Erysipelotrichaceae | Eubacterium | Eubacterium rectale | Faecalibacterium | Faecalibacterium prausnitzii | Haemophilus | Klebsiella | Lachnobacterium | Lachnospira | Lachnospiraceae | Neisseria | Odoribacter | Oscillospira | Parabacteroides | Paraprevotella | Phascolarctobacterium | Prevotella | Pseudomonas | Roseburia hominis | Roseburia intestinalis | Roseburia inulinivorans | Streptococcus
Obesity 0.0868 33 (0.09) : Actinobacteria | Aggregatibacter actinomycetemcomitans | Alistipes | Bacteroides | Bifidobacterium | Campylobacter rectus | Capnocytophaga ochracea | Capnocytophaga sputigena | Clostridium symbiosum | Corynebacterium | Dialister | Escherichia | Fusobacterium | Fusobacterium nucleatum | Fusobacterium periodonticum | Gemella | Haemophilus | Lactobacillus | Methanobrevibacter | Neisseria mucosa | Parabacteroides | Prevotella | Pseudomonas | Roseburia | Staphylococcus | Stenotrophomonas | Streptococcus anginosus | Streptococcus constellatus | Streptococcus gordonii | Streptococcus intermedius | Streptococcus mutans | Streptococcus sanguinis | Veillonella parvula 29 (0.08) : Acinetobacter | Akkermansia | Akkermansia muciniphila | Anaerostipes | Atopobium | Bacteriodes uniformis | Bacteroides ovatus | Bacteroides vulgatus | Bifidobacterium | Bifidobacterium adolescentis | Butyricimonas | Clostridium leptum | Coprococcus | Eubacterium | Faecalibacterium | Faecalibacterium prausnitzii | Fusobacterium | Haemophilus parainfluenzae | Klebsiella | Lachnospira | Lachnospiraceae | Megamonas | Odoribacter | Oscillospira | Parabacteroides | Paraprevotella | Phascolarctobacterium | Prevotella | Streptococcus
Colorectal cancer 0.0782 27 (0.05) : Acinetobacter | Actinomyces | Akkermansia muciniphila | Bacteroides | Bifidobacterium | Burkholderia | Clostridium ramosum | Clostridium symbiosum | Enterococcus | Escherichia | Escherichia coli | Eubacterium | Fusobacterium | Fusobacterium nucleatum | Gemella | Klebsiella | Lactobacillus | Leptotrichia | Parvimonas micra | Peptostreptococcus | Prevotella | Pseudomonas | Roseburia | Ruminococcaceae | Stenotrophomonas | Streptococcus | Streptococcus anginosus 33 (0.11) : Acinetobacter | Akkermansia | Anaerostipes | Atopobium | Bacteriodes uniformis | Bacteroides ovatus | Bifidobacterium | Blautia coccoides | Clostridium leptum | Collinsella | Coprococcus | Dialister invisus | Dorea | Eubacterium | Eubacterium rectale | Faecalibacterium | Faecalibacterium prausnitzii | Haemophilus | Klebsiella | Lachnospira | Lachnospiraceae | Megamonas | Neisseria | Parabacteroides | Paraprevotella | Phascolarctobacterium | Prevotella | Prevotella copri | Propionibacterium | Pseudomonas | Staphylococcus | Streptococcus | Sutterella
Autism 0.0728 27 (0.06) : Akkermansia muciniphila | Bacteroides | Bacteroides intestinalis | Bifidobacterium | Burkholderia | Clostridium boltae | Clostridium clostridioforme | Clostridium hathewayi | Clostridium ramosum | Clostridium symbiosum | Corynebacterium | Dorea | Eggerthella lenta | Enterococcus | Haemophilus | Lachnospiraceae | Lactobacillus | Lactobacillus reuteri | Megasphaera | Parabacteroides | Parabacteroides distasonis | Pseudomonas | Roseburia | Ruminococcaceae | Ruminococcus gnavus | Shigella | Streptococcus 32 (0.09) : Adlercreutzia | Akkermansia | Anaerostipes | Atopobium | Bacteriodes uniformis | Bacteroides vulgatus | Bifidobacterium | Bifidobacterium adolescentis | Bilophila | Butyricimonas | Clostridium bartletti | Clostridium butyricum | Clostridium leptum | Collinsella | Coprococcus | Dialister invisus | Erysipelotrichaceae | Eubacterium rectale | Faecalibacterium prausnitzii | Fusobacterium | Haemophilus parainfluenzae | Lachnospiraceae | Odoribacter | Oscillospira | Parabacteroides | Peptoniphilus | Phascolarctobacterium | Prevotella | Roseburia intestinalis | Ruminococcus lactaris | Streptococcus | Terrisporobacter glycolicus
HIV infection 0.0638 17 (0.03) : Acinetobacter | Capnocytophaga ochracea | Corynebacterium | Desulfovibrio piger | Escherichia | Eubacterium biforme | Finegoldia | Fusobacterium | Haemophilus | Klebsiella | Lactobacillus | Megasphaera elsdenii | Peptostreptococcus | Prevotella | Shigella | Stenotrophomonas | Streptococcus 25 (0.10) : Aggregatibacter | Akkermansia | Arcanobacterium | Bifidobacterium | Bilophila | Campylobacter | Collinsella | Coprococcus | Dorea | Eubacterium | Faecalibacterium | Fusobacterium | Haemophilus | Lachnobacterium | Lachnospira | Lachnospiraceae | Neisseria | Odoribacter | Oscillospira | Parabacteroides | Prevotella | Propionibacterium | Pseudomonas | Staphylococcus | Streptococcus
Primary sclerosing cholangitis-IBD 0.0622 17 (0.07) : Acidaminococcus | Acinetobacter | Bifidobacterium | Corynebacterium | Enterococcus | Escherichia | Fusobacterium | Haemophilus | Lachnospiraceae | Lactobacillus | Lactobacillus salivarius | Megasphaera | Roseburia | Sphingomonas | Staphylococcus | Streptococcus | Veillonella parvula 8 (0.05) : Dorea | Faecalibacterium prausnitzii | Lachnospira | Parabacteroides | Phascolarctobacterium | Prevotella | Prevotella copri | Sutterella
Gastric carcinoma 0.0614 19 (0.08) : Acinetobacter | Alistipes | Bacteroides | Bifidobacterium | Corynebacterium | Fusobacterium | Gemella | Klebsiella | Lachnospiraceae | Lactobacillus | Neisseria | Parabacteroides | Peptostreptococcus | Prevotella | Ruminococcaceae | Selenomonas | Shigella | Streptococcus | Streptococcus anginosus 9 (0.04) : Acinetobacter | Bacteriodes uniformis | Eubacterium rectale | Faecalibacterium | Lachnospira | Neisseria | Prevotella | Prevotella copri | Streptococcus
Alcoholism 0.0611 19 (0.06) : Acidaminococcus | Actinomyces | Bacteroides | Corynebacterium | Dialister | Enterococcus | Escherichia | Eubacterium | Haemophilus | Klebsiella | Lachnospiraceae | Lactobacillus | Lactobacillus salivarius | Leptotrichia | Neisseria | Parabacteroides | Prevotella | Staphylococcus | Streptococcus 12 (0.06) : Adlercreutzia | Akkermansia | Anaerostipes | Bifidobacterium | Collinsella | Coprococcus | Dorea | Faecalibacterium | Lachnospiraceae | Odoribacter | Prevotella | Staphylococcus
Hepatocellular cancer 0.0608 21 (0.07) : Acidaminococcus | Actinobacteria | Actinomyces | Alistipes | Bacteroides | Dorea | Eggerthella | Enterococcus | Escherichia coli | Eubacterium | Fusobacterium | Gemella | Lachnospiraceae | Leptotrichia | Parabacteroides | Prevotella | Pseudomonas | Ruminococcaceae | Shigella | Streptococcus | Subdoligranulum 10 (0.05) : Adlercreutzia | Aggregatibacter | Akkermansia | Bifidobacterium | Collinsella | Haemophilus | Klebsiella | Phascolarctobacterium | Pseudomonas | Streptococcus
Clostridium difficile infection 0.0576 11 (0.04) : Akkermansia muciniphila | Corynebacterium | Dorea | Eggerthella | Enterococcus | Escherichia coli | Klebsiella | Lactobacillus | Parabacteroides | Shigella | Staphylococcus 15 (0.08) : Akkermansia | Anaerostipes | Bifidobacterium | Butyricimonas | Collinsella | Coprococcus | Faecalibacterium | Faecalibacterium prausnitzii | Haemophilus | Lachnospira | Odoribacter | Oscillospira | Paraprevotella | Phascolarctobacterium | Prevotella
Irritable bowel syndrome 0.0567 19 (0.04) : Acinetobacter | Actinomyces | Alistipes | Bacteroides | Bifidobacterium | Clostridium symbiosum | Dialister | Dorea | Enterococcus | Escherichia | Escherichia coli | Klebsiella | Lactobacillus | Prevotella | Roseburia | Ruminococcus gnavus | Staphylococcus | Streptococcus | Streptococcus intermedius 20 (0.07) : Acinetobacter | Anaerostipes | Bacteriodes uniformis | Bacteroides ovatus | Bacteroides vulgatus | Bifidobacterium | Blautia coccoides | Coprococcus | Dorea | Eubacterium | Faecalibacterium | Fusobacterium | Haemophilus | Lachnospira | Lachnospiraceae | Neisseria | Odoribacter | Parabacteroides | Staphylococcus | Streptococcus
Cirrhosis 0.0524 23 (0.07) : Acidaminococcus | Bacteroides | Burkholderia | Dialister | Enterococcus | Escherichia coli | Eubacterium | Fusobacterium | Haemophilus | Klebsiella | Lactobacillus | Lactobacillus salivarius | Megasphaera | Olsenella | Parabacteroides | Prevotella | Pseudomonas | Ruminococcus gnavus | Streptococcaceae | Streptococcus | Streptococcus anginosus | Streptococcus salivarius | Veillonella parvula 15 (0.03) : Aggregatibacter | Akkermansia | Bacteriodes uniformis | Bifidobacterium | Campylobacter | Dorea | Eubacterium rectale | Faecalibacterium prausnitzii | Haemophilus | Lachnospira | Lachnospiraceae | Neisseria | Prevotella | Roseburia hominis | Roseburia intestinalis
Cystic fibrosis 0.0501 15 (0.05) : Actinobacteria | Bacteroides | Clostridium clostridioforme | Enterococcus | Escherichia coli | Eubacterium biforme | Lachnospiraceae | Megasphaera | Pseudomonas | Ruminococcus gnavus | Selenomonas | Shigella | Staphylococcus | Streptococcus | Veillonella parvula 22 (0.05) : Akkermansia muciniphila | Bacteriodes uniformis | Bacteroides ovatus | Bacteroides vulgatus | Bifidobacterium | Bifidobacterium adolescentis | Campylobacter | Dialister invisus | Erysipelotrichaceae | Eubacterium rectale | Faecalibacterium | Faecalibacterium prausnitzii | Fusobacterium | Lachnospiraceae | Moraxellaceae | Neisseria | Novosphingobium | Odoribacter | Prevotella | Roseburia hominis | Roseburia intestinalis | Roseburia inulinivorans
Ulcerative Colitis 0.0500 20 (0.04) : Actinomyces | Bacteroides | Bifidobacteriaceae | Bifidobacterium | Burkholderia | Clostridium ramosum | Dorea | Eggerthella | Enterococcus | Escherichia coli | Fusobacterium nucleatum | Gemella | Haemophilus | Lactobacillus | Prevotella | Roseburia | Ruminococcaceae | Ruminococcus gnavus | Shigella | Streptococcus 22 (0.06) : Akkermansia muciniphila | Bifidobacterium | Bilophila | Blautia coccoides | Butyricimonas | Clostridium leptum | Coprococcus | Eubacterium | Eubacterium rectale | Faecalibacterium prausnitzii | Haemophilus | Lachnobacterium | Lachnospira | Lachnospiraceae | Neisseria | Odoribacter | Oscillospira | Phascolarctobacterium | Prevotella | Pseudomonas | Roseburia hominis | Streptococcus
Chronic alcoholic pancreatitis 0.0487 6 (0.02) : Acinetobacter | Enterococcus | Pseudomonas | Sphingomonas | Staphylococcus | Streptococcus 11 (0.07) : Anaerostipes | Bilophila | Faecalibacterium | Fusobacterium | Lachnospira | Odoribacter | Oscillospira | Parabacteroides | Paraprevotella | Prevotella | Sutterella
Hypertension 0.0471 13 (0.06) : Actinomyces | Bifidobacterium | Dorea | Eggerthella | Fusobacterium | Klebsiella | Lactobacillus | Megasphaera | Parabacteroides | Prevotella | Ruminococcaceae | Shigella | Streptococcus 8 (0.03) : Bifidobacterium | Coprococcus | Dorea | Eubacterium rectale | Faecalibacterium | Klebsiella | Odoribacter | Oscillospira
Short Bowel Syndrome 0.0470 11 (0.05) : Enterococcus | Escherichia | Fusobacterium | Haemophilus | Klebsiella | Lactobacillus | Megasphaera | Neisseria | Prevotella | Shigella | Streptococcus 12 (0.05) : Acinetobacter | Akkermansia | Anaerostipes | Clostridium leptum | Collinsella | Dorea | Erysipelotrichaceae | Faecalibacterium | Lachnospira | Lachnospiraceae | Parabacteroides | Prevotella
Chronic kidney disease 0.0469 19 (0.06) : Acinetobacter | Actinomyces | Actinomyces naeslundii | Bacteroides | Bifidobacterium | Corynebacterium | Eggerthella | Escherichia coli | Lactobacillus | Lactobacillus salivarius | Neisseria | Parabacteroides | Pseudomonas | Ruminococcus gnavus | Sediminibacterium | Shigella | Streptococcus | Streptococcus mutans | Subdoligranulum 13 (0.04) : Akkermansia | Bifidobacterium | Collinsella | Coprococcus | Dorea | Eubacterium rectale | Faecalibacterium | Faecalibacterium prausnitzii | Lachnospira | Megamonas | Prevotella | Pseudomonas | Streptococcus
Chronic Obstructive Pulmonary Disease 0.0454 21 (0.07) : Actinomyces | Bifidobacterium | Burkholderia | Chryseobacterium | Clostridium symbiosum | Corynebacterium | Dialister | Eubacterium | Fusobacterium | Haemophilus | Lactobacillus | Leptotrichia | Neisseria | Olsenella | Peptostreptococcus | Prevotella | Pseudomonas | Selenomonas | Stenotrophomonas | Streptococcus | Tannerella 9 (0.02) : Acinetobacter | Campylobacter | Filifactor | Haemophilus parainfluenzae | Neisseria | Novosphingobium | Prevotella | Staphylococcus | Streptococcus
Multiple Sclerosis 0.0427 18 (0.05) : Actinobacteria | Actinomyces | Akkermansia muciniphila | Alistipes | Bacteroides | Bifidobacterium | Dorea | Eggerthella | Eggerthella lenta | Haemophilus | Lactobacillus | Lactobacillus reuteri | Methanobrevibacter | Olsenella | Parabacteroides | Shigella | Streptococcus | Streptococcus salivarius 11 (0.03) : Butyricimonas | Dorea | Erysipelotrichaceae | Eubacterium rectale | Faecalibacterium | Faecalibacterium prausnitzii | Lachnospira | Lachnospiraceae | Prevotella | Prevotella copri | Pseudomonas
Psoriasis 0.0424 22 (0.05) : Actinomyces | Bacteroides | Bifidobacterium | Brevibacterium | Comamonas | Dialister | Dorea | Enterococcus | Finegoldia | Lachnospiraceae | Megasphaera | Parabacteroides | Pedobacter | Peptostreptococcus | Prevotella | Pseudomonas | Ruminococcus gnavus | Sphingomonas | Staphylococcus | Streptococcaceae | Streptococcus | Subdoligranulum 12 (0.03) : Akkermansia muciniphila | Coprococcus | Faecalibacterium | Lachnospira | Lachnospiraceae | Parabacteroides | Paraprevotella | Prevotella copri | Propionibacterium | Staphylococcus | Streptococcus | Sutterella
Hepatitis B 0.0421 9 (0.03) : Actinomyces | Alistipes | Bacteroides | Eubacterium | Fusobacterium | Haemophilus | Lactobacillus | Prevotella | Streptococcus 10 (0.05) : Aggregatibacter | Anaerostipes | Bifidobacterium | Butyricimonas | Campylobacter | Faecalibacterium prausnitzii | Parabacteroides | Paraprevotella | Phascolarctobacterium | Prevotella
Parkinson's Disease 0.0408 30 (0.05) : Acidaminococcus | Acinetobacter | Akkermansia muciniphila | Alistipes | Bacteroides | Bifidobacteriaceae | Bifidobacterium | Dialister | Eggerthella lenta | Enterococcus | Klebsiella | Lachnospiraceae | Lactobacillus | Lactobacillus acidophilus | Lactobacillus bulgaricus | Lactobacillus plantarum | Lactobacillus reuteri | Lactobacillus ruminis | Lactobacillus salivarius | Microbacterium | Parabacteroides | Prevotella | Roseburia | Ruminococcaceae | Shigella | Sphingomonas | Streptococcus | Streptococcus mutans | Subdoligranulum | Verrucomicrobia 15 (0.03) : Blautia coccoides | Clostridium leptum | Collinsella | Coprococcus | Dorea | Faecalibacterium | Faecalibacterium prausnitzii | Haemophilus | Lachnospira | Lachnospiraceae | Neisseria | Prevotella | Prevotella copri | Roseburia intestinalis | Streptococcus
Ankylosing spondylitis 0.0407 13 (0.05) : Actinomyces | Bifidobacterium | Corynebacterium | Dorea | Eggerthella | Escherichia coli | Lachnospiraceae | Megasphaera | Neisseria | Parabacteroides distasonis | Prevotella | Ruminococcaceae | Streptococcus 7 (0.03) : Campylobacter | Eubacterium | Fusobacterium | Klebsiella | Lachnospira | Odoribacter | Parabacteroides
Celiac Disease 0.0402 15 (0.05) : Bacteroides | Dorea | Escherichia coli | Gemella | Klebsiella | Lachnospiraceae | Lactobacillus | Megasphaera | Neisseria | Parabacteroides distasonis | Prevotella | Shigella | Staphylococcus | Streptococcus sanguinis | Veillonella parvula 10 (0.03) : Acinetobacter | Akkermansia | Anaerostipes | Bifidobacterium | Dorea | Faecalibacterium prausnitzii | Lachnospiraceae | Pediococcus | Prevotella | Staphylococcus
Rheumatoid Arthritis 0.0397 18 (0.05) : Actinomyces | Aggregatibacter actinomycetemcomitans | Comamonas | Corynebacterium matruchotii | Eggerthella | Eggerthella lenta | Fusobacterium | Gemella | Haemophilus | Halomonas | Klebsiella | Kocuria | Lactobacillus | Leptotrichia | Neisseria | Prevotella | Selenomonas | Streptococcus 12 (0.03) : Acinetobacter | Bifidobacterium | Collinsella | Erysipelotrichaceae | Eubacterium rectale | Haemophilus | Lachnospira | Moraxellaceae | Prevotella | Pseudomonas | Staphylococcus | Streptococcus
Primary biliary cholangitis 0.0389 8 (0.03) : Eubacterium | Fusobacterium | Haemophilus | Klebsiella | Lactobacillus | Prevotella | Pseudomonas | Streptococcus 8 (0.04) : Akkermansia | Butyricimonas | Faecalibacterium | Fusobacterium | Odoribacter | Oscillospira | Phascolarctobacterium | Sutterella
Primary sclerosing cholangitis 0.0383 11 (0.04) : Bacteroides | Enterococcus | Escherichia coli | Fusobacterium | Haemophilus | Lactobacillus | Neisseria | Parabacteroides | Staphylococcus | Streptococcus | Veillonella parvula 9 (0.04) : Anaerostipes | Coprococcus | Faecalibacterium | Faecalibacterium prausnitzii | Haemophilus | Lachnospiraceae | Parabacteroides | Phascolarctobacterium | Prevotella copri
Type 1 diabetes 0.0365 7 (0.01) : Alistipes | Bacteroides | Bifidobacterium | Escherichia coli | Lactobacillus acidophilus | Prevotella | Streptococcus 15 (0.06) : Akkermansia | Akkermansia muciniphila | Anaerostipes | Bacteroides vulgatus | Bifidobacterium | Blautia coccoides | Eubacterium rectale | Faecalibacterium | Faecalibacterium prausnitzii | Haemophilus | Lachnospira | Lachnospiraceae | Megamonas | Prevotella | Staphylococcus
Asthma 0.0364 18 (0.05) : Acidaminococcus | Actinomyces | Alistipes | Bacteroides | Escherichia coli | Eubacterium | Gemella | Haemophilus | Klebsiella | Lactobacillus | Lactobacillus rhamnosus | Parabacteroides | Pseudomonas | Roseburia | Rubellimicrobium | Stenotrophomonas | Streptococcus | Weeksella 11 (0.02) : Acinetobacter | Aggregatibacter | Bifidobacterium | Faecalibacterium | Filifactor | Fusobacterium | Lachnospira | Neisseria | Prevotella | Staphylococcus | Streptococcus
Coronary artery disease 0.0352 13 (0.03) : Bacteroides | Comamonas | Enterococcus | Haemophilus | Klebsiella | Lactobacillus | Megasphaera | Parabacteroides distasonis | Prevotella | Pseudomonas | Ruminococcus gnavus | Shigella | Streptococcus 10 (0.04) : Acinetobacter | Coprococcus | Dorea | Erysipelotrichaceae | Eubacterium rectale | Faecalibacterium | Lachnospira | Lachnospiraceae | Staphylococcus | Streptococcus
Major depressive disorder 0.0349 9 (0.03) : Actinomyces | Alistipes | Bacteroides | Bifidobacteriaceae | Eggerthella | Eubacterium | Parabacteroides | Roseburia | Streptococcus 8 (0.04) : Bifidobacterium | Coprococcus | Eubacterium | Faecalibacterium | Lachnospiraceae | Phascolarctobacterium | Prevotella | Sutterella
Pancreatitis 0.0349 8 (0.03) : Alistipes | Bacteroides | Enterococcus | Parabacteroides | Prevotella | Shigella | Staphylococcus | Stenotrophomonas 7 (0.04) : Acinetobacter | Bifidobacterium | Faecalibacterium | Faecalibacterium prausnitzii | Lachnospiraceae | Prevotella | Pseudomonas
Chronic pancreatitis 0.0347 3 (0.03) : Dialister | Parabacteroides | Shigella 6 (0.04) : Collinsella | Dorea | Erysipelotrichaceae | Faecalibacterium | Lachnospiraceae | Megamonas
Pulmonary tubercolosis 0.0344 8 (0.02) : Acinetobacter | Actinobacteria | Clostridium boltae | Escherichia | Escherichia coli | Lactobacillus | Staphylococcus | Streptococcus 12 (0.05) : Akkermansia muciniphila | Bifidobacterium adolescentis | Coprococcus | Eubacterium rectale | Haemophilus parainfluenzae | Lachnospira | Prevotella | Roseburia hominis | Roseburia intestinalis | Roseburia inulinivorans | Ruminococcus lactaris | Streptococcus
Migraine 0.0338 10 (0.05) : Clostridium boltae | Clostridium clostridioforme | Clostridium hathewayi | Clostridium ramosum | Clostridium symbiosum | Eggerthella lenta | Lachnospiraceae | Pseudomonas | Ruminococcus gnavus | Streptococcus 2 (0.01) : Bifidobacterium adolescentis | Faecalibacterium prausnitzii
Smoking 0.0335 17 (0.05) : Actinomyces | Bacteroides | Bifidobacterium | Campylobacter rectus | Corynebacterium | Corynebacterium matruchotii | Fusobacterium | Fusobacterium nucleatum | Gemella | Lactobacillus | Neisseria | Parvimonas micra | Prevotella | Selenomonas | Staphylococcus | Streptococcus | Streptococcus salivarius 7 (0.01) : Aggregatibacter | Haemophilus | Neisseria | Neisseria flavescens | Prevotella | Staphylococcus | Streptococcus
Glycogen storage disease 0.0326 5 (0.04) : Bifidobacterium | Lactobacillus | Ruminococcus gnavus | Shigella | Subdoligranulum 5 (0.02) : Anaerostipes | Coprococcus | Faecalibacterium | Odoribacter | Phascolarctobacterium
Fibromyalgia 0.0305 4 (0.01) : Alistipes | Dorea | Roseburia | Ruminococcaceae 7 (0.05) : Bacteriodes uniformis | Bifidobacterium | Eubacterium | Faecalibacterium prausnitzii | Haemophilus parainfluenzae | Lachnospiraceae | Prevotella copri
Influenza A 0.0298 7 (0.03) : Acinetobacter | Actinomyces | Eubacterium | Halomonas | Lactobacillus | Pseudomonas | Streptococcus 5 (0.02) : Fusobacterium | Haemophilus | Neisseria | Staphylococcus | Streptococcus
Inflamatory bowel disease 0.0296 8 (0.02) : Clostridium bolteae | Clostridium hathewayi | Enterococcus | Gemella | Prevotella | Ruminococcus gnavus | Sphingomonas | Streptococcus anginosus 10 (0.04) : Anaerostipes | Bifidobacterium | Coprococcus | Eubacterium rectale | Faecalibacterium | Faecalibacterium prausnitzii | Lachnobacterium | Parabacteroides | Prevotella | Roseburia hominis
Atopic Dermatitis 0.0295 7 (0.01) : Bacteroides | Corynebacterium | Escherichia coli | Lactobacillus | Parabacteroides | Staphylococcus | Streptococcus 13 (0.04) : Akkermansia | Atopobium | Bacteroides ovatus | Bacteroides vulgatus | Bifidobacterium | Coprococcus | Eubacterium | Klebsiella | Propionibacterium | Proteobacteria | Pseudomonas | Staphylococcus | Streptococcus
Pancreatic Cancer 0.0295 10 (0.03) : Acidaminococcus | Aggregatibacter actinomycetemcomitans | Haemophilus | Klebsiella | Lachnospiraceae | Lactobacillus | Leptotrichia | Megasphaera | Prevotella | Selenomonas 9 (0.03) : Akkermansia | Anaerostipes | Bifidobacterium | Bilophila | Coprococcus | Dorea | Faecalibacterium | Megamonas | Parabacteroides
Alzheimer's disease 0.0294 11 (0.04) : Alistipes | Bacteroides | Bifidobacterium | Dorea | Escherichia | Gemella | Lactobacillus | Pseudomonas | Ruminococcaceae | Shigella | Streptococcus 8 (0.02) : Acinetobacter | Adlercreutzia | Bifidobacterium | Eubacterium rectale | Lachnospiraceae | Parabacteroides | Paraprevotella | Sutterella
Non-alcoholic fatty liver disease 0.0293 9 (0.02) : Bacteroides | Dorea | Enterococcus | Escherichia | Lachnospiraceae | Lactobacillus | Lactobacillus ruminis | Roseburia | Streptococcus 14 (0.04) : Anaerostipes | Bifidobacterium adolescentis | Bilophila | Coprococcus | Dorea | Erysipelotrichaceae | Faecalibacterium | Faecalibacterium prausnitzii | Odoribacter | Oscillospira | Parabacteroides | Prevotella | Prevotella copri | Pseudomonas
Lung cancer 0.0291 9 (0.03) : Bacteroides | Bifidobacterium | Enterococcus | Lachnospiraceae | Parabacteroides distasonis | Prevotella | Ruminococcus gnavus | Sphingomonas | Streptococcus 7 (0.03) : Acinetobacter | Bifidobacterium | Bifidobacterium adolescentis | Erysipelotrichaceae | Faecalibacterium prausnitzii | Parabacteroides | Streptococcus
Generalized anxiety disorder 0.0291 5 (0.02) : Bacteroides | Burkholderia | Fusobacterium | Ruminococcus gnavus | Shigella 9 (0.04) : Acinetobacter | Coprococcus | Eubacterium rectale | Faecalibacterium | Lachnospira | Lachnospiraceae | Megamonas | Prevotella | Sutterella
H7N9 0.0287 7 (0.05) : Bacteroides | Bifidobacteriaceae | Fusobacterium | Leptotrichia | Megasphaera | Pseudomonas | Tannerella 1 (0.01) : Haemophilus
Behcet's Disease 0.0285 8 (0.02) : Acidaminococcus | Bifidobacterium | Eggerthella | Eggerthella lenta | Fusobacterium | Lactobacillus salivarius | Parabacteroides | Streptococcus 11 (0.03) : Campylobacter | Coprococcus | Dialister invisus | Eubacterium | Filifactor | Lachnospiraceae | Megamonas | Neisseria | Prevotella | Prevotella copri | Pyramidobacter piscolens
Urogenital Schistosomiasis 0.0282 10 (0.05) : Acinetobacter | Bacteroides | Dialister | Enterococcus | Fusobacterium | Haemophilus | Lactobacillus | Megasphaera | Olsenella | Prevotella 3 (0.01) : Erysipelotrichaceae | Parabacteroides | Staphylococcus
Severe fever with thrombocytopenia syndrome 0.0279 5 (0.03) : Enterococcus | Escherichia | Lactobacillus | Roseburia | Streptococcus 4 (0.03) : Anaerostipes | Faecalibacterium | Lachnospira | Prevotella
Extrinsic black dental staining 0.0274 8 (0.05) : Actinomyces | Actinomyces naeslundii | Corynebacterium | Fusobacterium | Haemophilus | Leptotrichia | Peptostreptococcus | Tannerella 1 (0.01) : Campylobacter
Cirrhosis with pneumonia 0.0267 5 (0.04) : Actinomyces | Bacteroides | Eubacterium | Lachnospiraceae | Neisseria 1 (0.01) : Streptococcus
Biliary atresia 0.0267 4 (0.03) : Enterococcus | Klebsiella | Lactobacillus | Streptococcus 4 (0.02) : Anaerostipes | Bifidobacterium | Faecalibacterium | Haemophilus
Infective colitis 0.0262 1 (0.01) : Bacteroides 4 (0.04) : Bifidobacterium | Blautia coccoides | Clostridium leptum | Faecalibacterium prausnitzii
Aggressive periodontitis 0.0260 9 (0.02) : Campylobacter showae | Eubacterium | Fusobacterium nucleatum | Leptotrichia | Parvimonas micra | Peptostreptococcus | Prevotella | Streptococcus sanguinis | Tannerella 13 (0.03) : Akkermansia | Bifidobacterium | Campylobacter | Corynebacterium matruchotii | Faecalibacterium | Haemophilus | Haemophilus parainfluenzae | Lachnospiraceae | Leptotrichiaceae | Oscillospira | Prevotella | Pseudomonas | Streptococcus
Kidney stone 0.0259 9 (0.03) : Acinetobacter | Alistipes | Bacteroides | Eubacterium biforme | Lachnospiraceae | Parabacteroides | Parabacteroides distasonis | Shigella | Veillonella parvula 6 (0.02) : Anaerostipes | Bilophila | Dorea | Faecalibacterium | Peptoniphilus | Prevotella
Alcoholic Hepatitis 0.0255 8 (0.02) : Actinomyces | Bifidobacterium | Dorea | Enterococcus | Haemophilus | Lactobacillus | Microbacterium | Streptococcus 7 (0.03) : Acinetobacter | Akkermansia | Bilophila | Odoribacter | Oscillospira | Parabacteroides | Prevotella
Caries 0.0254 17 (0.03) : Acinetobacter | Actinomyces | Comamonas | Haemophilus | Lachnospiraceae | Lactobacillus | Lactobacillus gasseri | Lactobacillus salivarius | Leptotrichia | Megasphaera | Prevotella | Pseudomonas | Selenomonas | Streptococcus | Streptococcus mutans | Streptococcus salivarius | Veillonella parvula 12 (0.02) : Capnocytophaga ochracea | Corynebacterium matruchotii | Filifactor | Fusobacterium | Haemophilus | Haemophilus parainfluenzae | Lachnospiraceae | Neisseria | Prevotella | Propionibacterium | Pseudomonas | Streptococcus
Systemic lupus erythematosus 0.0253 16 (0.05) : Actinomyces | Aggregatibacter actinomycetemcomitans | Corynebacterium | Deinococcus | Dialister | Eggerthella | Eubacterium | Fusobacterium | Klebsiella | Lachnospiraceae | Lactobacillus | Megasphaera | Prevotella | Pseudomonas | Ruminococcus gnavus | Streptococcus anginosus 4 (0.01) : Bifidobacterium | Faecalibacterium prausnitzii | Haemophilus parainfluenzae | Prevotella
Schizophrenia 0.0251 18 (0.04) : Actinomyces | Akkermansia muciniphila | Clostridium symbiosum | Dorea | Eggerthella | Escherichia | Klebsiella | Lactobacillus | Lactobacillus gasseri | Lactobacillus salivarius | Megasphaera | Megasphaera elsdenii | Methanobrevibacter | Ruminococcus gnavus | Shigella | Streptococcus gordonii | Streptococcus salivarius | Veillonella parvula 7 (0.01) : Coprococcus | Erysipelotrichaceae | Faecalibacterium | Fusobacterium | Haemophilus | Lachnospiraceae | Sutterella
Idiopathic focal epilepsy 0.0248 3 (0.02) : Delftia | Haemophilus | Neisseria 5 (0.03) : Bifidobacterium | Collinsella | Coprococcus | Faecalibacterium | Parabacteroides
Osteoporosis 0.0247 8 (0.05) : Actinomyces | Bacteroides | Capnocytophaga ochracea | Eggerthella | Lactobacillus | Lactobacillus reuteri | Parabacteroides | Ruminococcaceae 0 (0.00)
Pervasive developmental disorder NOS 0.0242 1 (0.00) : Dorea 10 (0.05) : Bacteriodes uniformis | Bacteroides ovatus | Bacteroides vulgatus | Clostridium bartletti | Fusobacterium | Oscillospira | Parabacteroides | Prevotella copri | Roseburia hominis | Roseburia intestinalis
Thyroid carcinoma 0.0242 9 (0.03) : Alistipes | Klebsiella | Lactobacillus | Neisseria | Prevotella | Roseburia | Shigella | Streptococcus | Subdoligranulum 5 (0.02) : Butyricimonas | Megamonas | Phascolarctobacterium | Prevotella | Sutterella
Atherosclerosis 0.0240 7 (0.02) : Eggerthella lenta | Escherichia coli | Fusobacterium nucleatum | Klebsiella | Lactobacillus salivarius | Ruminococcus gnavus | Streptococcus 5 (0.02) : Eubacterium | Faecalibacterium prausnitzii | Prevotella copri | Roseburia intestinalis | Roseburia inulinivorans
Collagenous colitis 0.0231 4 (0.03) : Bacteroides | Lachnospiraceae | Methanobrevibacter | Parabacteroides 3 (0.01) : Akkermansia | Collinsella | Coprococcus
Sjögren syndrome 0.0223 10 (0.02) : Bifidobacterium | Delftia | Dialister | Escherichia | Fusobacterium nucleatum | Lactobacillus | Prevotella | Streptococcus | Streptococcus mutans | Streptococcus salivarius 10 (0.02) : Bifidobacterium | Cellulosilyticum ruminicola | Dorea | Faecalibacterium | Fusobacterium | Haemophilus | Neisseria | Neisseria flavescens | Parabacteroides | Prevotella
Hepatitis C 0.0222 8 (0.04) : Acinetobacter | Escherichia | Haemophilus | Lactobacillus | Lactobacillus salivarius | Micrococcus | Prevotella | Streptococcus 3 (0.01) : Bilophila | Butyricimonas | Parabacteroides
Autoimmune hepatitis 0.0214 3 (0.02) : Klebsiella | Lactobacillus | Streptococcus 5 (0.03) : Bifidobacterium | Coprococcus | Oscillospira | Parabacteroides | Streptococcus
Hand, foot and mouth disease 0.0213 4 (0.03) : Bifidobacterium | Enterococcus | Escherichia | Streptococcus 2 (0.01) : Dorea | Phascolarctobacterium
Bleeding gum 0.0213 5 (0.04) : Fusobacterium | Gemella | Neisseria | Olsenella | Prevotella 2 (0.01) : Haemophilus | Streptococcus
Non alcoholic steatohepatitis 0.0212 5 (0.01) : Dorea | Escherichia | Lactobacillus | Lactobacillus ruminis | Prevotella 6 (0.03) : Bifidobacterium | Bifidobacterium adolescentis | Clostridium leptum | Coprococcus | Eubacterium | Oscillospira
Sicca syndrome 0.0211 9 (0.03) : Actinomyces | Fusobacterium nucleatum | Megasphaera | Peptostreptococcus | Prevotella | Ruminococcaceae | Shuttleworthia | Streptococcus mutans | Streptococcus salivarius 4 (0.01) : Aquabacterium | Neisseria | Neisseria flavescens | Streptococcus
Systemic sclerosis 0.0210 6 (0.03) : Actinobacteria | Bifidobacterium | Burkholderia | Fusobacterium | Lactobacillus | Prevotella 3 (0.02) : Faecalibacterium | Propionibacterium | Staphylococcus
Chronic Laryngitis 0.0210 2 (0.02) : Pseudomonas | Streptococcus 5 (0.02) : Aquabacterium | Neisseria | Prevotella | Propionibacterium | Staphylococcus
Tongue cancer 0.0209 5 (0.03) : Actinomyces | Corynebacterium | Enterococcus | Micrococcus | Streptococcus 5 (0.02) : Aggregatibacter | Campylobacter | Fusobacterium | Peptoniphilus | Prevotella
Acute lymphoblastic leukemia 0.0206 1 (0.00) : Bacteroides 7 (0.04) : Atopobium | Bifidobacterium | Campylobacter | Faecalibacterium | Peptoniphilus | Prevotella | Staphylococcus
Oral lichen planus 0.0205 6 (0.02) : Campylobacter rectus | Fusobacterium | Fusobacterium nucleatum | Leptotrichia | Neisseria mucosa | Prevotella 6 (0.02) : Aggregatibacter | Haemophilus | Haemophilus parainfluenzae | Neisseria | Proteobacteria | Streptococcus
Covid-19 0.0197 6 (0.02) : Actinomyces | Actinomyces viscosus | Clostridium hathewayi | Clostridium ramosum | Lactobacillus rhamnosus | Streptococcus 6 (0.02) : Anaerostipes | Coprococcus | Eubacterium rectale | Faecalibacterium | Faecalibacterium prausnitzii | Lachnospiraceae
Acquired Immunodeficiency Syndrome 0.0195 3 (0.01) : Enterococcus | Lactobacillus | Streptococcus 6 (0.03) : Bacteriodes uniformis | Bacteroides vulgatus | Faecalibacterium | Lachnospira | Megamonas | Prevotella
Hirschsprung's disease 0.0195 5 (0.04) : Actinomyces | Dialister | Escherichia | Prevotella | Pseudomonas 1 (0.00) : Lachnospiraceae
Transient Ischemic Attack 0.0191 6 (0.02) : Alistipes | Eubacterium | Lactobacillus | Megasphaera | Parabacteroides | Subdoligranulum 3 (0.02) : Faecalibacterium | Paraprevotella | Prevotella
Gestational diabetes + hyperlipidemia 0.0191 4 (0.03) : Actinomyces | Haemophilus | Prevotella | Streptococcus 1 (0.01) : Faecalibacterium
Chronic stress 0.0191 4 (0.03) : Bacteroides | Methanobrevibacter | Parabacteroides | Roseburia 1 (0.01) : Phascolarctobacterium
Oral cancer 0.0190 13 (0.04) : Actinomyces | Fusobacterium | Gemella | Haemophilus | Lactobacillus | Neisseria | Peptostreptococcus | Prevotella | Streptococcus | Streptococcus anginosus | Streptococcus gordonii | Streptococcus salivarius | Veillonella parvula 2 (0.00) : Haemophilus | Streptococcus
Cholestasis 0.0188 5 (0.02) : Enterococcus | Megasphaera | Staphylococcus | Streptococcus | Streptococcus salivarius 5 (0.02) : Anaerostipes | Bifidobacterium | Collinsella | Faecalibacterium | Faecalibacterium prausnitzii
Pancreatic head cancer 0.0185 7 (0.03) : Actinomyces | Corynebacterium | Eubacterium | Fusobacterium | Leptotrichia | Peptostreptococcus | Tannerella 2 (0.01) : Haemophilus | Paraprevotella
Stevens-Johnson syndrome 0.0183 11 (0.04) : Acinetobacter | Bacteroides | Bifidobacterium | Fusobacterium | Lactobacillus | Methanobrevibacter | Prevotella | Pseudomonas | Roseburia | Staphylococcus | Streptococcus 0 (0.00)
Idiopathic Pulmonary Fibrosis 0.0180 5 (0.02) : Actinobacteria | Haemophilus | Neisseria | Prevotella | Streptococcus 3 (0.02) : Coprococcus | Dorea | Sutterella
Gestational diabetes 0.0178 10 (0.03) : Actinomyces | Bacteroides | Enterococcus | Klebsiella | Lachnospiraceae | Olsenella | Parabacteroides distasonis | Prevotella | Ruminococcaceae | Shigella 2 (0.00) : Parabacteroides | Prevotella
Spinal cord injury 0.0173 4 (0.02) : Bacteroides | Corynebacterium | Escherichia coli | Shigella 4 (0.02) : Eubacterium rectale | Faecalibacterium | Megamonas | Prevotella
Spondyloarthritis 0.0169 5 (0.03) : Bifidobacterium | Dialister | Dorea | Lachnospiraceae | Ruminococcus gnavus 2 (0.01) : Faecalibacterium prausnitzii | Lachnospiraceae
Anti-N-methyl-D-aspartate receptor encephalitis 0.0169 4 (0.03) : Bacteroides | Fusobacterium | Parabacteroides | Streptococcus 0 (0.00)
Wiskott-Aldrich syndrome 0.0168 1 (0.00) : Shigella 4 (0.03) : Faecalibacterium | Parabacteroides | Phascolarctobacterium | Sutterella
Interstitial cystitis 0.0167 3 (0.01) : Bacteroides | Bifidobacterium | Enterococcus 7 (0.02) : Campylobacter | Coprococcus | Eubacterium | Faecalibacterium | Prevotella | Propionibacterium | Streptococcus
Heart failure 0.0166 4 (0.01) : Enterococcus | Fusobacterium | Lactobacillus | Streptococcus 5 (0.02) : Bilophila | Collinsella | Dorea | Eubacterium rectale | Faecalibacterium prausnitzii
Otitis Media 0.0166 7 (0.02) : Fusobacterium | Gemella | Haemophilus | Klebsiella | Neisseria | Prevotella | Streptococcus 4 (0.01) : Acinetobacter | Propionibacterium | Proteobacteria | Streptococcus
Maturity-onset diabetes of the young 2 0.0166 1 (0.01) : Prevotella 3 (0.02) : Anaerostipes | Faecalibacterium | Lachnospira
Frailty 0.0166 2 (0.01) : Dorea | Eggerthella lenta 2 (0.02) : Faecalibacterium prausnitzii | Lachnospiraceae
Pouchitis 0.0164 5 (0.01) : Escherichia | Eubacterium | Prevotella | Roseburia | Streptococcus 4 (0.02) : Faecalibacterium | Lachnospiraceae | Parabacteroides | Streptococcus
Amyotrophic lateral sclerosis 0.0163 6 (0.02) : Akkermansia muciniphila | Escherichia coli | Lachnospiraceae | Methanobrevibacter | Parabacteroides | Parabacteroides distasonis 3 (0.02) : Dorea | Faecalibacterium | Megamonas
Bacterial vaginosis 0.0151 14 (0.03) : Acinetobacter | Actinomyces | Dialister | Eggerthella | Fusobacterium nucleatum | Lachnospiraceae | Lactobacillus acidophilus | Leptotrichia | Megasphaera | Peptostreptococcus | Prevotella | Streptococcus | Streptococcus anginosus | Streptococcus sanguinis 0 (0.00)
Infantile eczema 0.0151 3 (0.00) : Parabacteroides | Roseburia | Shigella 8 (0.03) : Bifidobacterium | Collinsella | Dorea | Haemophilus | Klebsiella | Prevotella | Streptococcus | Sutterella
Neuromyelitis optica 0.0151 4 (0.01) : Bacteroides | Corynebacterium | Shigella | Streptococcus 5 (0.02) : Coprococcus | Faecalibacterium | Lachnospiraceae | Prevotella copri | Sutterella
Invasive colorectal cancer 0.0151 5 (0.03) : Corynebacterium | Enterococcus | Fusobacterium | Fusobacterium nucleatum | Neisseria 0 (0.00)
Colon adenomas 0.0145 5 (0.01) : Dorea | Fusobacterium | Pseudomonas | Shigella | Subdoligranulum 5 (0.02) : Butyricimonas | Collinsella | Coprococcus | Lachnobacterium | Moraxellaceae
Macular degeneration 0.0145 6 (0.02) : Actinomyces | Finegoldia | Gemella | Prevotella | Staphylococcus | Streptococcus 2 (0.01) : Fusobacterium | Prevotella
Vulvar vestibulitis syndrome 0.0145 3 (0.03) : Enterococcus | Lactobacillus gasseri | Streptococcus 1 (0.00) : Atopobium
Graves' disease 0.0140 2 (0.01) : Haemophilus | Prevotella 4 (0.02) : Bifidobacterium | Eubacterium | Faecalibacterium | Parabacteroides
Human end-stage renal disease 0.0139 2 (0.00) : Eggerthella lenta | Fusobacterium 5 (0.02) : Bifidobacterium | Eubacterium rectale | Faecalibacterium prausnitzii | Lachnospira | Prevotella copri
Microscopic colitis 0.0138 2 (0.00) : Lachnospiraceae | Veillonella parvula 6 (0.02) : Akkermansia | Akkermansia muciniphila | Coprococcus | Prevotella | Propionibacterium | Staphylococcus
Keratitis 0.0134 1 (0.00) : Dorea 7 (0.03) : Bifidobacterium adolescentis | Dorea | Faecalibacterium | Faecalibacterium prausnitzii | Klebsiella | Lachnospira | Sutterella
Cardiac valve calcification 0.0134 3 (0.01) : Enterococcus | Fusobacterium | Lactobacillus 3 (0.01) : Dorea | Erysipelotrichaceae | Megamonas
Fibrosis 0.0134 1 (0.00) : Streptococcus 3 (0.02) : Coprococcus | Faecalibacterium prausnitzii | Oscillospira
Myasthenia gravis 0.0132 5 (0.02) : Acidaminococcus | Acinetobacter | Bacteroides | Escherichia | Streptococcus 3 (0.01) : Eubacterium | Faecalibacterium prausnitzii | Paraprevotella
Seminal hyperviscosity 0.0127 3 (0.03) : Klebsiella | Neisseria | Pseudomonas 0 (0.00)
Oligoasthenoteratozoospermia 0.0127 3 (0.03) : Klebsiella | Neisseria | Pseudomonas 0 (0.00)
Allergy 0.0125 3 (0.01) : Dorea | Roseburia | Ruminococcus gnavus 3 (0.01) : Coprococcus | Lachnospira | Prevotella
Allergic asthma 0.0124 1 (0.00) : Bifidobacterium 2 (0.02) : Akkermansia muciniphila | Faecalibacterium prausnitzii
Autoimmune Thyroid Disorders 0.0124 0 (0.00) 3 (0.02) : Akkermansia muciniphila | Bifidobacterium | Faecalibacterium prausnitzii
Endometriosis 0.0121 8 (0.02) : Acinetobacter | Corynebacterium | Delftia | Prevotella | Pseudomonas | Shigella | Sphingomonas | Streptococcus 2 (0.01) : Atopobium | Prevotella
Eosinophilic esophagitis 0.0120 3 (0.02) : Corynebacterium | Haemophilus | Neisseria 2 (0.01) : Leptotrichiaceae | Streptococcus
Iron-deficiency anaemia 0.0120 3 (0.02) : Enterococcus | Lactobacillus | Pseudomonas 2 (0.01) : Aggregatibacter | Neisseria
Helicobacter pylori infection 0.0119 5 (0.01) : Acinetobacter | Enterococcus | Haemophilus | Leptotrichia | Sphingomonas 5 (0.02) : Aggregatibacter | Bacteroides vulgatus | Fusobacterium | Klebsiella | Streptococcus
Chronic fatigue syndrome 0.0117 5 (0.02) : Actinobacteria | Alistipes | Enterococcus | Streptococcus | Streptococcus sanguinis 3 (0.01) : Bifidobacterium | Eubacterium | Faecalibacterium
Rectal Carcinoma 0.0116 2 (0.01) : Bacteroides | Parabacteroides 3 (0.02) : Acinetobacter | Bifidobacterium | Pseudomonas
Gingivitis 0.0116 1 (0.01) : Streptococcus 2 (0.01) : Prevotella | Streptococcus
Severe congenital neutropenia 0.0116 1 (0.01) : Leptotrichia 2 (0.01) : Fusobacterium | Haemophilus
Bladder cancer 0.0114 7 (0.02) : Acinetobacter | Fusobacterium | Fusobacterium nucleatum | Ruminococcaceae | Shigella | Sphingomonas | Subdoligranulum 3 (0.01) : Bifidobacterium | Prevotella | Streptococcus
Arsenic exposure 0.0113 2 (0.01) : Enterococcus | Streptococcus 3 (0.01) : Bifidobacterium | Coprococcus | Parabacteroides
Uveitits 0.0111 5 (0.02) : Burkholderia | Halomonas | Prevotella | Selenomonas | Streptococcus 5 (0.01) : Dorea | Faecalibacterium | Lachnospira | Odoribacter | Pseudomonas
Cavernous angioma 0.0110 0 (0.00) 2 (0.02) : Bifidobacterium adolescentis | Faecalibacterium prausnitzii
Cystic fibrosis exacerbation 0.0110 0 (0.00) 4 (0.02) : Haemophilus | Pseudomonas | Staphylococcus | Streptococcus
Traumatic Brain Injury 0.0110 0 (0.00) 2 (0.02) : Prevotella copri | Sutterella
Acne 0.0108 5 (0.01) : Bacteroides | Corynebacterium | Enterococcus | Klebsiella | Staphylococcus 6 (0.01) : Bifidobacterium | Bilophila | Lachnospira | Paraprevotella | Propionibacterium | Proteobacteria
Postmenopausal 0.0108 3 (0.01) : Bacteroides | Prevotella | Staphylococcus 2 (0.01) : Eubacterium | Faecalibacterium
Polycystic ovary syndrome 0.0106 3 (0.01) : Finegoldia | Lactobacillus | Prevotella 4 (0.01) : Akkermansia | Faecalibacterium | Parabacteroides | Prevotella
Periodontal disease 0.0106 6 (0.01) : Fusobacterium nucleatum | Parvimonas micra | Prevotella | Selenomonas | Streptococcus constellatus | Tannerella 5 (0.01) : Atopobium | Haemophilus | Haemophilus parainfluenzae | Neisseria flavescens | Streptococcus
Barrett's oesophagus 0.0106 4 (0.01) : Campylobacter rectus | Fusobacterium | Neisseria | Sphingomonas 2 (0.01) : Aggregatibacter | Streptococcus
Chagas' disease 0.0106 5 (0.02) : Enterococcus | Fusobacterium | Lactobacillus | Roseburia | Streptococcus 0 (0.00)
Aphthous ulcer 0.0103 5 (0.02) : Lactobacillus | Prevotella | Shigella | Streptococcus anginosus | Streptococcus salivarius 2 (0.00) : Haemophilus | Streptococcus
Invasive pneumococcal disease 0.0103 5 (0.02) : Acinetobacter | Actinomyces | Megasphaera | Prevotella | Streptococcus 1 (0.01) : Staphylococcus
Edentulism 0.0103 9 (0.02) : Comamonas | Dialister | Eubacterium | Leptotrichia | Megasphaera | Peptostreptococcus | Selenomonas | Streptococcus anginosus | Streptococcus salivarius 1 (0.00) : Dialister invisus
Attention Deficit Hyperactivity Disorder 0.0102 4 (0.01) : Bacteroides caccae | Bifidobacterium | Fusobacterium | Veillonella parvula 3 (0.01) : Faecalibacterium | Faecalibacterium prausnitzii | Lachnospiraceae
Laryngeal carcinoma 0.0101 7 (0.02) : Burkholderia | Dialister | Fusobacterium | Peptostreptococcus | Prevotella | Selenomonas | Staphylococcus 1 (0.00) : Streptococcus
Atrophic gastritis 0.0101 2 (0.01) : Bacteroides | Parabacteroides 3 (0.01) : Faecalibacterium | Lachnospiraceae | Prevotella copri
Oral potentially malignant disorder 0.0100 8 (0.02) : Capnocytophaga ochracea | Corynebacterium matruchotii | Eubacterium saburreum | Fusobacterium nucleatum | Parvimonas micra | Streptococcus gordonii | Streptococcus salivarius | Veillonella parvula 0 (0.00)
Coronary Heart Disease 0.0098 0 (0.00) 4 (0.02) : Collinsella | Parabacteroides | Prevotella | Proteobacteria
Blepharitis 0.0097 2 (0.01) : Corynebacterium | Staphylococcus 1 (0.01) : Propionibacterium
Hashimoto's thyroiditis 0.0097 3 (0.01) : Dorea | Escherichia coli | Roseburia 3 (0.01) : Bifidobacterium | Faecalibacterium | Prevotella
COPD Exacerbation 0.0097 2 (0.00) : Acinetobacter | Haemophilus 4 (0.01) : Campylobacter | Lachnospiraceae | Prevotella | Streptococcus
Juvenile idiopathic arthritis 0.0096 5 (0.02) : Dorea | Klebsiella | Parabacteroides | Parabacteroides distasonis | Ruminococcaceae 0 (0.00)
Metabolic syndrome 0.0096 1 (0.00) : Akkermansia muciniphila 4 (0.02) : Bifidobacterium | Faecalibacterium prausnitzii | Roseburia intestinalis | Roseburia inulinivorans
Obstructive sleep apnea-hypopnea syndrome 0.0094 5 (0.02) : Fusobacterium | Haemophilus | Prevotella | Pseudomonas | Streptococcus 3 (0.00) : Bifidobacterium | Leptotrichiaceae | Megamonas
Overactive bladder 0.0092 2 (0.00) : Gemella | Staphylococcus 4 (0.01) : Campylobacter | Fusobacterium | Novosphingobium | Prevotella
Vaginal Chlamydiosis 0.0090 8 (0.02) : Corynebacterium | Delftia | Dialister | Lactobacillus | Megasphaera | Prevotella | Pseudomonas | Streptococcus 0 (0.00)
Preeclamsia 0.0089 4 (0.01) : Dialister | Escherichia | Fusobacterium | Prevotella 3 (0.01) : Akkermansia | Faecalibacterium | Lachnospira
Sickle cell disease 0.0086 1 (0.01) : Escherichia 2 (0.01) : Faecalibacterium | Prevotella
Ischemic stroke 0.0086 2 (0.00) : Enterococcus | Lactobacillus ruminis 3 (0.01) : Anaerostipes | Faecalibacterium | Lachnospiraceae
Conjunctival scarring 0.0085 2 (0.02) : Corynebacterium | Streptococcus 0 (0.00)
Prediabetes 0.0084 2 (0.01) : Dorea | Streptococcus 1 (0.01) : Akkermansia muciniphila
Wilson's Disease 0.0084 1 (0.00) : Bacteroides 2 (0.01) : Phascolarctobacterium | Prevotella
Obesity (Diet induced) 0.0083 2 (0.01) : Lactobacillus gasseri | Lactobacillus plantarum 1 (0.01) : Akkermansia muciniphila
Melanoma 0.0083 2 (0.01) : Bifidobacterium | Ruminococcaceae 1 (0.01) : Faecalibacterium
Head/Neck cancer 0.0083 2 (0.01) : Stenotrophomonas | Streptococcus anginosus 3 (0.01) : Fusobacterium | Haemophilus parainfluenzae | Lachnospiraceae
Halitosis 0.0081 6 (0.01) : Dialister | Leptotrichia | Peptostreptococcus | Prevotella | Selenomonas | Tannerella 2 (0.00) : Haemophilus parainfluenzae | Streptococcus
Aerobic vaginitis 0.0081 10 (0.02) : Dialister | Enterococcus | Escherichia | Escherichia coli | Finegoldia | Haemophilus | Megasphaera elsdenii | Staphylococcus | Streptococcus | Streptococcus anginosus 0 (0.00)
Silicosis 0.0081 3 (0.02) : Dialister | Lachnospiraceae | Parabacteroides 1 (0.00) : Bifidobacterium
Hepatic encephalopathy 0.0079 5 (0.01) : Bifidobacterium | Burkholderia | Enterococcus | Megasphaera | Streptococcaceae 2 (0.00) : Faecalibacterium | Lachnospiraceae
Anovulation 0.0079 2 (0.01) : Dialister | Prevotella 3 (0.01) : Anaerostipes | Lachnospiraceae | Oscillospira
Reactive arthritis 0.0076 1 (0.00) : Pseudomonas 2 (0.01) : Collinsella | Coprococcus
Infant colic 0.0076 1 (0.00) : Acinetobacter 1 (0.01) : Bifidobacterium
Laryngotracheal stenosis 0.0076 1 (0.00) : Acinetobacter 1 (0.01) : Prevotella
Diabetic nephropathy 0.0076 1 (0.00) : Shigella 1 (0.01) : Prevotella
Fatigue 0.0076 1 (0.00) : Ruminococcus gnavus 2 (0.01) : Faecalibacterium prausnitzii | Roseburia hominis
Cutaneous burn 0.0075 3 (0.01) : Enterococcus | Halomonas | Staphylococcus 1 (0.01) : Streptococcus
Clonorchis sinensis infection 0.0075 3 (0.01) : Dorea | Microbacterium | Sphingomonas 2 (0.01) : Parabacteroides | Paraprevotella
Primary liver cancer 0.0075 4 (0.02) : Enterococcus | Escherichia coli | Ruminococcus gnavus | Shigella 0 (0.00)
Alcoholic cirrhosis 0.0075 3 (0.01) : Lactobacillus salivarius | Staphylococcus | Streptococcus mutans 2 (0.01) : Paraprevotella | Prevotella
Liver transplant 0.0073 0 (0.00) 2 (0.01) : Bifidobacterium | Faecalibacterium prausnitzii
Protracted bacterial bronchitis 0.0073 6 (0.01) : Bifidobacterium | Enterococcus | Haemophilus | Prevotella | Pseudomonas | Shuttleworthia 0 (0.00)
Autoimmune polyendocrine syndrome type 1 0.0073 2 (0.01) : Capnocytophaga ochracea | Fusobacterium nucleatum 3 (0.00) : Haemophilus parainfluenzae | Lachnospiraceae | Neisseria flavescens
Primary Open-Angle Glaucoma 0.0070 2 (0.01) : Escherichia coli | Streptococcus 1 (0.01) : Megamonas
Hyperthyroidism 0.0070 1 (0.01) : Enterococcus 1 (0.01) : Bifidobacterium
Bullous pemphigoid 0.0070 2 (0.01) : Corynebacterium | Staphylococcus 1 (0.01) : Proteobacteria
Atopic wheeze 0.0070 2 (0.01) : Ruminococcus gnavus | Streptococcus 1 (0.01) : Bifidobacterium
Intrahepatic Cholangiocarcinoma 0.0070 2 (0.01) : Actinomyces | Lactobacillus 1 (0.01) : Lachnospira
Neuro-Behcet's disease 0.0070 1 (0.01) : Parabacteroides 1 (0.01) : Lachnospiraceae
Kaposi's sarcoma 0.0070 2 (0.01) : Corynebacterium | Dialister 1 (0.00) : Aggregatibacter
Constipation 0.0069 2 (0.00) : Acinetobacter | Enterococcus 3 (0.01) : Adlercreutzia | Odoribacter | Prevotella
Pregnancy 0.0067 3 (0.01) : Lactobacillus gasseri | Neisseria | Streptococcus 4 (0.01) : Actinomycetales | Peptoniphilus | Prevotella | Streptococcus
Chronic Rhinosinusitis 0.0066 3 (0.00) : Escherichia | Fusobacterium | Pseudomonas 4 (0.01) : Lachnospiraceae | Parabacteroides | Peptoniphilus | Propionibacterium
Bipolar disorder 0.0066 3 (0.01) : Bacteroides | Halomonas | Parabacteroides 2 (0.01) : Coprococcus | Faecalibacterium
Pressure ulcers 0.0066 5 (0.01) : Bacteroides | Dorea | Enterococcus | Parabacteroides distasonis | Ruminococcus gnavus 0 (0.00)
Psychogenic erectile dysfunction 0.0065 1 (0.00) : Subdoligranulum 2 (0.01) : Lachnospiraceae | Prevotella
Dandruff 0.0064 5 (0.01) : Leptotrichia | Micrococcus | Pseudomonas | Selenomonas | Staphylococcus 1 (0.00) : Propionibacterium
Granulomatosis with polyangiitis 0.0064 3 (0.01) : Corynebacterium | Staphylococcus | Streptococcaceae 1 (0.00) : Moraxellaceae
Common Variable Immunodeficieny 0.0064 3 (0.01) : Eggerthella | Gemella | Streptococcus 0 (0.00)
T2D with hypertension and hyperlipidemia 0.0061 1 (0.01) : Prevotella 1 (0.00) : Acinetobacter
Chronic mucocutaneous candidiasis 0.0061 1 (0.01) : Acinetobacter 1 (0.00) : Prevotella
Hyper IgE syndrome 0.0061 1 (0.01) : Acinetobacter 1 (0.00) : Prevotella
Trachoma 0.0056 2 (0.01) : Corynebacterium | Kocuria 0 (0.00)
Cervicitis 0.0056 2 (0.01) : Eggerthella | Prevotella 0 (0.00)
Cervical intraneoplasia 0.0056 2 (0.01) : Lactobacillus | Staphylococcus 0 (0.00)
Recurrent miscarriage 0.0056 2 (0.01) : Prevotella | Streptococcus 0 (0.00)
Down syndrome 0.0056 2 (0.01) : Streptococcus constellatus | Streptococcus gordonii 1 (0.01) : Capnocytophaga ochracea
Posttraumatic stress syndrome 0.0056 2 (0.01) : Acidaminococcus | Streptococcus 2 (0.01) : Anaerostipes | Lachnospira
Cardiovascular disease 0.0055 0 (0.00) 1 (0.01) : Proteobacteria
Rhinovirus infection 0.0055 0 (0.00) 1 (0.01) : Neisseria
Multiple system atrophy 0.0055 3 (0.01) : Akkermansia muciniphila | Bacteroides | Lactobacillus 2 (0.00) : Aggregatibacter | Haemophilus
Viral respiratory tract infection 0.0055 0 (0.00) 1 (0.01) : Prevotella
Spleen deficiency syndrome 0.0055 0 (0.00) 2 (0.01) : Akkermansia muciniphila | Prevotella copri
Human papilloma virus infection 0.0054 3 (0.01) : Capnocytophaga ochracea | Dialister | Eggerthella 0 (0.00)
Breast cancer 0.0054 5 (0.01) : Actinomyces | Alistipes | Corynebacterium | Fusobacterium | Staphylococcus 2 (0.00) : Prevotella | Streptococcus
Dry eye syndrom 0.0053 3 (0.01) : Megasphaera | Parabacteroides | Prevotella 1 (0.00) : Faecalibacterium
Rett Syndrome 0.0051 1 (0.00) : Bifidobacterium 2 (0.01) : Faecalibacterium | Streptococcus
Diarrhea 0.0049 1 (0.00) : Bacteroides 1 (0.01) : Bifidobacterium
Liver fibrosis 0.0048 2 (0.01) : Prevotella | Sphingomonas 1 (0.00) : Lachnospiraceae
Chronic urticaria 0.0044 0 (0.00) 2 (0.01) : Bifidobacterium | Faecalibacterium
Hemodialysis with Normal Weight Obesity 0.0044 0 (0.00) 2 (0.01) : Coprococcus | Faecalibacterium prausnitzii
Anorexia nervosa 0.0042 2 (0.01) : Akkermansia muciniphila | Enterococcus 1 (0.00) : Streptococcus
Denture Stomatitis 0.0042 1 (0.01) : Fusobacterium 0 (0.00)
Osmotic diarrhea 0.0042 1 (0.01) : Acinetobacter 0 (0.00)
Chronic Rhinosinusitis with cystic fibrosis 0.0042 2 (0.01) : Finegoldia | Streptococcus 0 (0.00)
Cleft palate 0.0042 1 (0.01) : Streptococcus 0 (0.00)
Giardia intestinalis infection 0.0042 1 (0.01) : Prevotella 0 (0.00)
Nasolacrimal duct obstruction 0.0042 1 (0.01) : Staphylococcus 0 (0.00)
Pneumonia 0.0040 1 (0.00) : Prevotella 2 (0.01) : Acinetobacter | Streptococcus
Seborrheic dermatitis 0.0039 2 (0.01) : Brevibacterium | Staphylococcus 1 (0.00) : Pseudomonas
Preterm birth 0.0038 3 (0.01) : Neisseria | Prevotella | Streptococcus 0 (0.00)
Bronchiectasis 0.0038 1 (0.00) : Pseudomonas 1 (0.01) : Haemophilus
Adolescent idiopathic scoliosis 0.0037 0 (0.00) 2 (0.01) : Campylobacter | Phascolarctobacterium
Idiopathic REM Sleep Behavior Disorder 0.0036 1 (0.00) : Eggerthella 2 (0.01) : Methanosphaera | Prevotella
Acute fatty liver 0.0035 2 (0.00) : Acinetobacter | Enterococcus 1 (0.00) : Adlercreutzia
Excessive vomiting 0.0035 2 (0.00) : Acinetobacter | Enterococcus 1 (0.00) : Adlercreutzia
Cervical cancer 0.0033 3 (0.00) : Dorea | Halomonas | Roseburia 1 (0.00) : Phascolarctobacterium
Urgency urinary incontinence 0.0032 3 (0.01) : Lactobacillus gasseri | Staphylococcus | Streptococcus anginosus 0 (0.00)
Genitourinary lichen sclerosus 0.0032 1 (0.00) : Lactobacillus 1 (0.00) : Staphylococcus
Necrotizing enterocolitis 0.0031 2 (0.00) : Enterococcus | Escherichia coli 1 (0.00) : Klebsiella
Kawasaki disease 0.0029 2 (0.00) : Eubacterium | Roseburia 1 (0.00) : Staphylococcus
Prostate cancer 0.0028 2 (0.01) : Akkermansia muciniphila | Escherichia 0 (0.00)
Primary biliary cirrhosis 0.0028 2 (0.00) : Klebsiella | Streptococcus 1 (0.00) : Lachnobacterium
Hepatitis B associated liver failure 0.0028 2 (0.01) : Burkholderia | Comamonas 0 (0.00)
Meningococcal disease 0.0028 2 (0.01) : Campylobacter rectus | Parvimonas micra 0 (0.00)
Gout 0.0027 0 (0.00) 1 (0.01) : Faecalibacterium prausnitzii
Tetratricopeptide repeat domain 7A deficiency 0.0027 0 (0.00) 1 (0.01) : Oscillospira
Neisseria gonorrhoeae infection 0.0027 0 (0.00) 1 (0.01) : Pseudomonas
Alopecia areata 0.0025 1 (0.00) : Actinobacteria 1 (0.00) : Staphylococcus
Functional dyspepsia 0.0024 2 (0.00) : Bacteroides | Shigella 0 (0.00)
Oral leukoplakia 0.0024 2 (0.00) : Fusobacterium nucleatum | Leptotrichia 0 (0.00)
Alopecia universalis 0.0024 2 (0.00) : Lachnospiraceae | Parabacteroides distasonis 0 (0.00)
Recurrent tonsillitis 0.0022 2 (0.00) : Streptococcus gordonii | Streptococcus intermedius 1 (0.00) : Haemophilus parainfluenzae
Refractory celiac disease 0.0022 1 (0.00) : Streptococcus intermedius 1 (0.00) : Haemophilus parainfluenzae
Exacerbations of idiopathic pulmonary fibrosis 0.0021 1 (0.00) : Stenotrophomonas 0 (0.00)
Budd-Chiari syndrome 0.0021 1 (0.00) : Megasphaera 0 (0.00)
Stomach cancer 0.0021 1 (0.00) : Subdoligranulum 0 (0.00)
Urolithiasis 0.0021 1 (0.00) : Lachnospiraceae 0 (0.00)
Biliary tract cancer 0.0021 1 (0.00) : Bifidobacteriaceae 0 (0.00)
Depression 0.0020 1 (0.00) : Lactobacillus 1 (0.00) : Coprococcus
T2D with hypertension 0.0020 1 (0.00) : Roseburia 1 (0.00) : Klebsiella
Graves' orbitopathy 0.0020 0 (0.00) 2 (0.00) : Anaerostipes | Collinsella
Colon polyps 0.0017 1 (0.00) : Ruminococcus gnavus 1 (0.00) : Fusobacterium
Tuberculosis 0.0015 2 (0.00) : Parvimonas micra | Streptococcus anginosus 0 (0.00)
Anxiety 0.0014 1 (0.00) : Lactobacillus plantarum 0 (0.00)
Vitiligo 0.0014 1 (0.00) : Dermacoccus 1 (0.00) : Pseudonocardia
Acne rosacea 0.0014 1 (0.00) : Actinobacteria 0 (0.00)
Atrial fibrilation 0.0014 0 (0.00) 1 (0.00) : Lachnobacterium
Aphthous stomatitis 0.0014 0 (0.00) 1 (0.00) : Akkermansia
Diverticular disease 0.0014 1 (0.00) : Ruminococcaceae 0 (0.00)
Radiation enteritis 0.0014 1 (0.00) : Prevotella 0 (0.00)
Primary immune thrombocytopenia 0.0014 0 (0.00) 1 (0.00) : Sutterella
Oropharyngeal cancer 0.0014 1 (0.00) : Streptococcus anginosus 1 (0.00) : Capnocytophaga ochracea
Diaper dermatitis 0.0013 1 (0.00) : Ruminococcus gnavus 1 (0.00) : Clostridium butyricum
Kidney stone with hypertension 0.0013 1 (0.00) : Lactobacillus 2 (0.00) : Bilophila | Phascolarctobacterium
Hypopharyngeal cancer 0.0013 1 (0.00) : Veillonella parvula 1 (0.00) : Capnocytophaga ochracea
Idiopathic central precocious puberty 0.0012 2 (0.00) : Acinetobacter | Pseudomonas 0 (0.00)
Clostridium difficile associated disease 0.0011 1 (0.00) : Actinobacteria 0 (0.00)
Nongonococcal urethritis 0.0011 1 (0.00) : Leptotrichia 0 (0.00)
Chronic ocular graft-versus-host disease 0.0011 1 (0.00) : Corynebacterium 0 (0.00)
Pulmonary arterial hypertension 0.0011 1 (0.00) : Ruminococcus gnavus 1 (0.00) : Akkermansia muciniphila

[Overlap Factors (Causality ?)]

FactorOverlapCommon increased OrganismCommon decreased Organism
Exposure to Glyphosate 0.0127 4 (0.02) : Actinomyces | Fusobacterium | Parabacteroides | Prevotella 1 (0.00) : Streptococcus
Cannabis smoking 0.0111 2 (0.01) : Actinomyces | Streptococcus 1 (0.01) : Neisseria
Aging 0.0110 0 (0.00) 2 (0.02) : Bifidobacterium | Faecalibacterium
Alcohol administration 0.0097 1 (0.01) : Actinobacteria 1 (0.01) : Akkermansia
Low FODMAP diet 0.0097 1 (0.01) : Bacteroides 1 (0.01) : Bifidobacterium
Consumption of Coffee 0.0075 4 (0.02) : Alistipes | Bifidobacterium | Dialister | Roseburia 0 (0.00)
Oral administration of Metformin 0.0074 3 (0.01) : Akkermansia muciniphila | Megasphaera | Ruminococcaceae 2 (0.01) : Dorea | Sutterella
High Water drinking 0.0061 1 (0.01) : Dorea 1 (0.00) : Odoribacter
Mediterranean diet 0.0056 2 (0.01) : Lachnospiraceae | Roseburia 0 (0.00)
Oral administration of Abiraterone acetate 0.0042 1 (0.01) : Akkermansia muciniphila 0 (0.00)
High Socio-economic status 0.0042 2 (0.01) : Eubacterium | Lachnospiraceae 0 (0.00)
Grape powder consumption 0.0038 1 (0.00) : Verrucomicrobia 1 (0.01) : Bifidobacterium
Maternal Antibiotic Exposure 0.0027 0 (0.00) 1 (0.01) : Bifidobacterium
Protein powder consumption 0.0024 0 (0.00) 2 (0.00) : Coprococcus | Lachnospiraceae
Probiotic (Bifidobacter and Lactobacilus) 0.0021 1 (0.00) : Bifidobacteriaceae 0 (0.00)
Sugar intake 0.0021 1 (0.00) : Akkermansia muciniphila 0 (0.00)
High salt diet 0.0021 1 (0.00) : Bifidobacterium 0 (0.00)
Milk Formula-feeding 0.0011 1 (0.00) : Bacteroides 0 (0.00)

[Reverse Overlap Factors (Curability ?)]

FactorOverlapIncrease decreased Org/DisDecrease increased Org/Dis
High Socio-economic status 0.0224 4 (0.03) : Anaerostipes | Eubacterium | Faecalibacterium | Lachnospiraceae 1 (0.01) : Bacteroides
High salt diet 0.0140 2 (0.02) : Akkermansia | Bifidobacterium 1 (0.01) : Lactobacillus
Heat Stress 0.0131 1 (0.00) : Oscillospira 2 (0.02) : Bacteroides | Lactobacillus
Grape powder consumption 0.0120 1 (0.00) : Akkermansia 2 (0.02) : Bifidobacterium | Dialister
Exposure to Glyphosate 0.0119 3 (0.01) : Fusobacterium | Parabacteroides | Prevotella 2 (0.01) : Lactobacillus | Streptococcus
High Water drinking 0.0116 1 (0.01) : Dorea 2 (0.01) : Bacteroides | Peptostreptococcus
Curcumin Supplementation 0.0110 0 (0.00) 2 (0.02) : Escherichia | Shigella
Sugar intake 0.0076 1 (0.00) : Akkermansia muciniphila 1 (0.01) : Lactobacillus
Oral administration of Metformin 0.0075 1 (0.00) : Akkermansia muciniphila 3 (0.01) : Dorea | Lactobacillus | Roseburia
Mediterranean diet 0.0075 2 (0.01) : Faecalibacterium prausnitzii | Lachnospiraceae 1 (0.00) : Ruminococcus gnavus
Aging 0.0070 1 (0.01) : Proteobacteria 1 (0.01) : Bifidobacterium
Cannabis smoking 0.0069 1 (0.00) : Streptococcus 1 (0.01) : Neisseria
High-fat diet 0.0062 0 (0.00) 3 (0.01) : Bifidobacteriaceae | Ruminococcaceae | Verrucomicrobia
Low FODMAP diet 0.0055 0 (0.00) 1 (0.01) : Bifidobacterium
Maternal Antibiotic Exposure 0.0049 1 (0.00) : Proteobacteria 1 (0.01) : Bifidobacterium
Consumption of Coffee 0.0042 3 (0.01) : Bifidobacterium | Faecalibacterium | Odoribacter 0 (0.00)
Oral administration of Abiraterone acetate 0.0042 1 (0.01) : Akkermansia muciniphila 0 (0.00)
Protein powder consumption 0.0024 0 (0.00) 2 (0.00) : Lachnospiraceae | Roseburia
Eating appel 0.0021 1 (0.00) : Akkermansia 0 (0.00)
Antibiotic Therapy 0.0014 1 (0.00) : Proteobacteria 0 (0.00)

Common References