MetaBiom
Microbiome & Chronic Diseases

Evidence Based Medicine

Type 2 diabetes {40000105}

Record Keys


Definition:
Type 2 diabetes
Class:[  ]

Details


Other Terms:
T2D, adult-onset diabetes
Authoring date:
2020-09-06

Links


Meta Information


ICD:[  ]
Category:[  ]
MedDra ID:
10067585
MedDra Level:
4

Notes


- Enterobacter cloacae B29 induced obesity and insulin resistance in germ-free mice. (3)

- PPI use is associated with reduced diversity of gut microbiome and consistent changes in the microbiota phenotype. (5)

Shared Notes


  • [1.33
    - Akkermansia muciniphila is a mucin degraders, an important role in the preservation of the integrity of the gut mucus layer, thus
    limiting the risk of systemic inflammation.
    - Dietary polyphenols such as anthocyanins (ACNs) and proanthocyanidins (PACs) protect against metabolic syndrome.
    - Supplementation of high-fat diets with ACNs or PACs has been shown to suppress the expression of genes involved in fatty acid and triacylglycerol synthesis, the regulation of lipogenesis and cholesterol biosynthesis, and the assembly of very low density
    lipoproteins.
    - ACNs and PACs have also been argued to stem the development of insulin resistance by increasing insulin signaling, glycogen accumulation and adiponectin secretion in the presence of free fatty acids.
    A. muciniphila abundance has been linked to reduced weight gain, adiposity, insulin resistance, and/or inflammatory markers in many contexts, including during pregnancy.
  • [1.34
    - Faecalibacterium prausnitzii, an indicator of inflammation, shows a decreased abundance in diabetes and obese persons.

Common References