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Microbiome & Chronic Diseases

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Irritable bowel syndrome {40000135}

Record Keys


Definition:
Irritable bowel syndrome
Class:[  ]

Details


Other Terms:
IBS
Initialisation date:
2020-09-06

Links


Meta Information


ICD:[  ]
Category:
Gastroenterology
MedDra ID:
10023003
MedDra Level:
pt

Notes


- Oral administration of Bifidobacterium infantis 35624 normalized sensitivity to colorectal distension in a rat model of post-inflammatory colonic hypersensitivity (1)

- The probiotic B. infantis 35624 reduced CRD-induced visceral pain behaviors in both rat strains. It significantly increased the threshold pressure of the first pain behavior and also reduced the total number pain behaviors during CRD (2)

- Purine metabolism is the novel host-microbial metabolic pathway in IBS (4)

Shared Notes


  • [1.23
    - Mice colonized with IBS+A microbiota developed faster gastrointestinal transit and anxiety‐like behavior (longer step‐down latency) compared to mice with HC microbiota.
    - Saccharomyces boulardii administration normalized gastrointestinal transit and anxiety‐like behavior in mice with IBS+A microbiota.

    Step‐down latency correlated with colonic Trpv1 expression and was associated with altered microbiota profile and increased Indole‐3‐acetic acid (IAA) levels.
  • [1.24
    - Individuals with severe IBS consumed a higher proportion of food items that can be considered as low quality (“less healthy”) as part of their main meals.
    - IBS severity is associated with altered gut microbiota hydrogen function in correlation with microbiota enzymes involved in animal carbohydrate metabolism.
  • [1.25
    - Staphylococcal bacterial infection and bacterial toxins can trigger an immune response that leads to the production of dietary-antigen-specific IgE antibodies in mice, which are limited to the intestine.
    - Following subsequent oral ingestion of the respective dietary antigen, an IgE- and mast-cell-dependent mechanism induced increased visceral pain.
    -This aberrant pain signalling resulted from histamine receptor H1-mediated sensitization of visceral afferents.
    - Injection of food antigens (gluten, wheat, soy and milk) into the rectosigmoid mucosa of patients with irritable bowel syndrome induced local oedema and mast cell activation.
  • [1.26
    - Streptococci and clostridia were associated with an increased risk.
    - Clostridium perfringens is a well-known enteric pathogen and streptococci have been previously associated with irritable bowel syndrome.
    - Demographic risk factors included a family history of irritable bowel syndrome and antibiotic use.
    - Half of those affected said that their parents or siblings had bowel disease, and 75% of those affected said they had taken antibiotics in the past year.
  • [1.27
    - Patients had a significant improvement from baseline to 12 weeks in total percentage of bowel movements.
    - Improvement was similar across IBS subtypes. Symptoms improved most in the first 4 weeks of intervention.
    - The most common side effects were mild gastrointestinal symptoms such as flatulence, abdominal pain and discomfort, and distension.
  • [1.29
    - Irritable bowel syndrome patients had lower urinary Phosphatidyl choline acyl-alkyl C38:6, dopamine and p-hydroxybenzoic acid.
    - Levels of some urinary metabolites including histamine correlated significantly with irritable bowel syndrome symptom severity scores.
  • [1.30
    - Combining human variables and gut microbiota achieved the best performances in predicting IBD, IBS, CDI, and unhealthy status, indicating independent associations between gut microbiota and these diseases.
  • [1.19
    - In IBS > The three most abundant bacteriophage clusters belonged to the Siphoviridae, Myoviridae, and Podoviridae families (Order Caudovirales).
  • [1.31
    - Bifidobacterium infantis seems to be effective in human studies with IBS patients by changing plasma proinflammatory to anti-inflammatory cytokine ratio.


[Overlap other Diseases]

DiseaseOverlapCommon increased OrganismCommon decreased Organism
Irritable bowel syndrome 1.0000 72 (1.00) : Acinetobacter | Actinomyces | Aeromonas | Alcaligenaceae | Alistipes | Allisonella | Alternaria alternata | Anaerovorax | Aneurinibacillus | Bacteroides | Bifidobacterium | Bifidobacterium infantis | Blautia | Butyricimonas | Candida solani | Candida tropicalis | Candidatus saccharibacteria bacterium | Candidatus soleaferrea | Citrobacter | Clostridioides difficile | Clostridium leptum | Clostridium symbiosum | Collinsella | Coprococcus eutactus | Dialister | Dorea | Enterobacter | Enterobacteriaceae | Enterococcus | Erysipelotrichia | Escherichia | Escherichia coli | Eubacterium ventriosum | Faecalibacterium prausnitzii | Faecalitalea | Flavonifractor plautii | Haemophilus parainfluenzae | Holdemania | Kazachstania turicensis | Klebsiella | Lachnoclostridium | Lachnospira | Lactobacillales | Lactobacillus | Leuconostoc | Marvinbryantia | Monographella nivalis | Myoviridae | Odoribacter | Oxalobacter | Papillibacter | Paraprevotella | Parasporobacterium | Peptococcus | Podoviridae | Prevotella | Prevotellace 62 (1.00) : Acinetobacter | Alistipes | Anaerostipes | Anaerovorax | Bacteriodes uniformis | Bacteroidales | Bacteroides | Bacteroides fragilis | Bacteroides intestinalis | Bacteroides ovatus | Bacteroides plebeius | Bacteroides stercoris | Bacteroides vulgatus | Bifidobacterium | Bifidobacterium catenulatum | Blautia | Blautia coccoides | Brevundimonas | Butyricicoccus | Christensenellaceae | Citrobacter | Clostridium cocleatum | Clostridium lituseburense | Collinsella aerofaciens | Coprococcus | Coprococcus eutactus | Davidiella tassiana | Dehalobacter | Desulfovibrio | Dorea | Eubacterium | Faecalibacterium | Fusibacter | Fusobacterium | Gemella | Haemophilus | Kazachstania telluris | Lachnospira | Lachnospiraceae | Lachnospiraceae incertae sedis | Lactobacillus | Microvirgula | Neisseria | Odoribacter | Oribacterium | Oscillibacter | Oxobacter | Parabacteroides | Penicillium spinulosum | Porphyromonadaceae | Prevotella oralis | Prevotella ruminicola | Prevotella tannerae | Prevotellaceae | Roseburia | Ruminococcaceae
Crohn's disease 0.0954 28 (0.08) : Acinetobacter | Actinomyces | Aeromonas | Anaerovorax | Bifidobacterium | Blautia | Candida tropicalis | Citrobacter | Clostridioides difficile | Clostridium leptum | Collinsella | Enterobacteriaceae | Enterococcus | Escherichia | Escherichia coli | Faecalibacterium prausnitzii | Flavonifractor plautii | Haemophilus parainfluenzae | Klebsiella | Lactobacillales | Lactobacillus | Odoribacter | Prevotella | Ruminococcus gnavus | Staphylococcus | Streptococcus | Streptococcus intermedius | Veillonella 33 (0.11) : Alistipes | Anaerostipes | Bacteriodes uniformis | Bacteroides | Bacteroides fragilis | Bacteroides vulgatus | Bifidobacterium | Bifidobacterium catenulatum | Blautia | Blautia coccoides | Christensenellaceae | Citrobacter | Clostridium lituseburense | Collinsella aerofaciens | Coprococcus | Coprococcus eutactus | Desulfovibrio | Dorea | Eubacterium | Faecalibacterium | Gemella | Haemophilus | Lachnospira | Lachnospiraceae | Lactobacillus | Neisseria | Odoribacter | Oscillibacter | Parabacteroides | Roseburia | Ruminococcaceae | Streptococcus | Vivictivallis
Colorectal cancer 0.0831 18 (0.04) : Acinetobacter | Actinomyces | Bacteroides | Bifidobacterium | Clostridioides difficile | Clostridium symbiosum | Collinsella | Enterobacteriaceae | Enterococcus | Escherichia | Escherichia coli | Klebsiella | Lactobacillus | Marvinbryantia | Paraprevotella | Prevotella | Roseburia | Streptococcus 30 (0.13) : Acinetobacter | Alistipes | Anaerostipes | Bacteriodes uniformis | Bacteroides | Bacteroides fragilis | Bacteroides intestinalis | Bacteroides ovatus | Bifidobacterium | Bifidobacterium catenulatum | Blautia | Blautia coccoides | Brevundimonas | Collinsella aerofaciens | Coprococcus | Desulfovibrio | Dorea | Eubacterium | Faecalibacterium | Haemophilus | Lachnospira | Lachnospiraceae | Lactobacillus | Neisseria | Oscillibacter | Parabacteroides | Roseburia | Ruminococcaceae | Staphylococcus | Streptococcus
Coronary artery disease 0.0790 11 (0.04) : Bacteroides | Butyricimonas | Collinsella | Enterococcus | Klebsiella | Lactobacillales | Lactobacillus | Odoribacter | Prevotella | Ruminococcus gnavus | Streptococcus 15 (0.12) : Acinetobacter | Bacteroides | Bacteroides plebeius | Blautia | Christensenellaceae | Coprococcus | Dorea | Faecalibacterium | Lachnospira | Lachnospiraceae | Roseburia | Ruminococcaceae | Staphylococcus | Streptococcus | Veillonella
Short Bowel Syndrome 0.0786 9 (0.05) : Citrobacter | Enterobacteriaceae | Enterococcus | Escherichia | Klebsiella | Lactobacillus | Prevotella | Streptococcus | Veillonella 15 (0.10) : Acinetobacter | Alistipes | Anaerostipes | Bacteroides | Blautia | Dorea | Faecalibacterium | Gemella | Lachnospira | Lachnospiraceae | Lactobacillus | Parabacteroides | Roseburia | Ruminococcaceae | Veillonella
Alcoholism 0.0755 18 (0.09) : Actinomyces | Alcaligenaceae | Bacteroides | Citrobacter | Collinsella | Dialister | Enterobacteriaceae | Enterococcus | Escherichia | Holdemania | Klebsiella | Lactobacillus | Odoribacter | Paraprevotella | Prevotella | Staphylococcus | Streptococcus | Veillonella 10 (0.06) : Anaerostipes | Bifidobacterium | Blautia | Coprococcus | Dorea | Faecalibacterium | Lachnospiraceae | Odoribacter | Oribacterium | Staphylococcus
HIV infection 0.0746 15 (0.04) : Acinetobacter | Allisonella | Candida tropicalis | Citrobacter | Enterobacter | Enterobacteriaceae | Escherichia | Haemophilus parainfluenzae | Klebsiella | Lactobacillus | Paraprevotella | Prevotella | Propionibacterium | Streptococcus | Veillonella 22 (0.11) : Alistipes | Bacteroides | Bifidobacterium | Blautia | Christensenellaceae | Coprococcus | Dorea | Eubacterium | Faecalibacterium | Fusobacterium | Haemophilus | Lachnospira | Lachnospiraceae | Neisseria | Odoribacter | Parabacteroides | Roseburia | Ruminococcaceae | Staphylococcus | Streptococcus | Veillonella | Vivictivallis
Ulcerative Colitis 0.0737 21 (0.08) : Actinomyces | Bacteroides | Bifidobacterium | Blautia | Citrobacter | Clostridioides difficile | Dorea | Enterobacteriaceae | Enterococcus | Escherichia coli | Flavonifractor plautii | Lachnospira | Lactobacillales | Lactobacillus | Myoviridae | Podoviridae | Prevotella | Roseburia | Ruminococcus gnavus | Streptococcus | Veillonella 20 (0.07) : Alistipes | Bacteroides | Bacteroides fragilis | Bifidobacterium | Blautia | Blautia coccoides | Christensenellaceae | Collinsella aerofaciens | Coprococcus | Desulfovibrio | Eubacterium | Haemophilus | Lachnospira | Lachnospiraceae | Lactobacillus | Neisseria | Odoribacter | Roseburia | Streptococcus | Vivictivallis
Atopic Dermatitis 0.0733 12 (0.07) : Bacteroides | Clostridioides difficile | Clostridium leptum | Coprococcus eutactus | Escherichia coli | Faecalibacterium prausnitzii | Lactobacillus | Propionibacterium | Ruminococcus lactaris | Staphylococcus | Streptococcus | Tyzzerella nexilis 14 (0.08) : Bacteroides fragilis | Bacteroides ovatus | Bacteroides plebeius | Bacteroides stercoris | Bacteroides vulgatus | Bifidobacterium | Blautia | Coprococcus | Coprococcus eutactus | Eubacterium | Lactobacillus | Staphylococcus | Streptococcus | Veillonella
Pouchitis 0.0717 8 (0.06) : Citrobacter | Enterobacteriaceae | Escherichia | Lachnospira | Prevotella | Roseburia | Streptococcus | Veillonella 7 (0.09) : Bacteroides | Faecalibacterium | Lachnospiraceae | Lactobacillus | Parabacteroides | Ruminococcaceae | Streptococcus
Biliary atresia 0.0717 4 (0.06) : Enterococcus | Klebsiella | Lactobacillus | Streptococcus 7 (0.09) : Anaerostipes | Bacteroides | Bifidobacterium | Blautia | Faecalibacterium | Haemophilus | Lachnospiraceae incertae sedis
Obesity 0.0714 18 (0.04) : Alcaligenaceae | Alistipes | Bacteroides | Bifidobacterium | Bifidobacterium infantis | Blautia | Clostridium symbiosum | Collinsella | Dialister | Escherichia | Faecalibacterium prausnitzii | Lachnospira | Lactobacillus | Prevotella | Prevotellaceae | Roseburia | Staphylococcus | Streptococcus intermedius 26 (0.10) : Acinetobacter | Alistipes | Anaerostipes | Anaerovorax | Bacteriodes uniformis | Bacteroides | Bacteroides ovatus | Bacteroides plebeius | Bacteroides vulgatus | Bifidobacterium | Blautia | Christensenellaceae | Coprococcus | Eubacterium | Faecalibacterium | Fusobacterium | Lachnospira | Lachnospiraceae | Lactobacillus | Odoribacter | Oscillibacter | Parabacteroides | Roseburia | Ruminococcaceae | Streptococcus | Veillonella
Cystic fibrosis 0.0691 14 (0.06) : Aeromonas | Bacteroides | Blautia | Clostridioides difficile | Enterobacteriaceae | Enterococcus | Escherichia coli | Lactobacillales | Leuconostoc | Ruminococcus gnavus | Staphylococcus | Streptococcus | Tyzzerella nexilis | Veillonella 21 (0.07) : Alistipes | Bacteriodes uniformis | Bacteroidales | Bacteroides | Bacteroides intestinalis | Bacteroides ovatus | Bacteroides vulgatus | Bifidobacterium | Bifidobacterium catenulatum | Blautia | Collinsella aerofaciens | Faecalibacterium | Fusobacterium | Gemella | Lachnospiraceae | Neisseria | Odoribacter | Prevotellaceae | Roseburia | Ruminococcaceae | Veillonella
Autoimmune hepatitis 0.0638 5 (0.07) : Klebsiella | Lactobacillales | Lactobacillus | Streptococcus | Veillonella 6 (0.06) : Bifidobacterium | Coprococcus | Lactobacillus | Parabacteroides | Ruminococcaceae | Streptococcus
Parkinson's Disease 0.0631 22 (0.05) : Acinetobacter | Alistipes | Bacteroides | Bifidobacterium | Blautia | Butyricimonas | Citrobacter | Dialister | Enterobacteriaceae | Enterococcus | Erysipelotrichia | Eubacterium ventriosum | Holdemania | Klebsiella | Lachnospira | Lactobacillus | Odoribacter | Paraprevotella | Prevotella | Roseburia | Streptococcus | Veillonella 21 (0.08) : Bacteroidales | Bacteroides fragilis | Bacteroides plebeius | Blautia | Blautia coccoides | Brevundimonas | Coprococcus | Coprococcus eutactus | Dorea | Faecalibacterium | Gemella | Haemophilus | Lachnospira | Lachnospiraceae | Lactobacillus | Neisseria | Prevotellaceae | Roseburia | Ruminococcaceae | Streptococcus | Veillonella
Clostridium difficile infection 0.0614 10 (0.05) : Citrobacter | Clostridioides difficile | Dorea | Enterobacteriaceae | Enterococcus | Escherichia coli | Klebsiella | Lactobacillus | Staphylococcus | Veillonella 12 (0.07) : Alistipes | Anaerostipes | Bacteroides | Bifidobacterium | Christensenellaceae | Coprococcus | Faecalibacterium | Haemophilus | Lachnospira | Odoribacter | Porphyromonadaceae | Ruminococcaceae
Autism 0.0588 21 (0.06) : Allisonella | Bacteroides | Bifidobacterium | Butyricimonas | Clostridioides difficile | Clostridium symbiosum | Collinsella | Dorea | Enterobacteriaceae | Enterococcus | Faecalibacterium prausnitzii | Flavonifractor plautii | Holdemania | Lachnospira | Lactobacillus | Odoribacter | Oxalobacter | Roseburia | Ruminococcus gnavus | Streptococcus | Veillonellaceae 22 (0.06) : Alistipes | Anaerostipes | Bacteriodes uniformis | Bacteroides | Bacteroides fragilis | Bacteroides vulgatus | Bifidobacterium | Blautia | Butyricicoccus | Coprococcus | Fusobacterium | Lachnospiraceae | Lactobacillus | Odoribacter | Oribacterium | Parabacteroides | Prevotellaceae | Roseburia | Ruminococcaceae | Streptococcus | Tannerella | Veillonella
Major depressive disorder 0.0586 7 (0.03) : Actinomyces | Alistipes | Bacteroides | Blautia | Roseburia | Streptococcus | Veillonella 10 (0.08) : Anaerovorax | Bacteroides | Bifidobacterium | Blautia | Coprococcus | Eubacterium | Faecalibacterium | Lachnospiraceae | Lactobacillus | Oscillibacter
Type 1 diabetes 0.0583 10 (0.04) : Alistipes | Bacteroides | Bifidobacterium | Blautia | Enterobacter | Enterobacteriaceae | Escherichia coli | Prevotella | Streptococcus | Veillonella 14 (0.08) : Alistipes | Anaerostipes | Bacteroidales | Bacteroides fragilis | Bacteroides vulgatus | Bifidobacterium | Blautia coccoides | Faecalibacterium | Haemophilus | Lachnospira | Lachnospiraceae | Lactobacillus | Roseburia | Staphylococcus
Chronic alcoholic pancreatitis 0.0582 5 (0.03) : Acinetobacter | Enterobacter | Enterococcus | Staphylococcus | Streptococcus 10 (0.09) : Anaerostipes | Bacteroides | Blautia | Desulfovibrio | Faecalibacterium | Fusobacterium | Lachnospira | Odoribacter | Parabacteroides | Roseburia
Type 2 diabetes 0.0567 19 (0.04) : Acinetobacter | Actinomyces | Alistipes | Bacteroides | Bifidobacterium | Clostridium symbiosum | Dialister | Dorea | Enterococcus | Escherichia | Escherichia coli | Klebsiella | Lactobacillus | Prevotella | Roseburia | Ruminococcus gnavus | Staphylococcus | Streptococcus | Streptococcus intermedius 20 (0.07) : Acinetobacter | Anaerostipes | Bacteriodes uniformis | Bacteroides ovatus | Bacteroides vulgatus | Bifidobacterium | Blautia coccoides | Coprococcus | Dorea | Eubacterium | Faecalibacterium | Fusobacterium | Haemophilus | Lachnospira | Lachnospiraceae | Neisseria | Odoribacter | Parabacteroides | Staphylococcus | Streptococcus
Glycogen storage disease 0.0555 3 (0.02) : Bifidobacterium | Lactobacillus | Ruminococcus gnavus 8 (0.09) : Alistipes | Anaerostipes | Blautia | Christensenellaceae | Coprococcus | Faecalibacterium | Odoribacter | Roseburia
Primary sclerosing cholangitis-IBD 0.0537 11 (0.05) : Acinetobacter | Bifidobacterium | Collinsella | Enterococcus | Escherichia | Lachnospira | Lactobacillus | Roseburia | Staphylococcus | Streptococcus | Veillonella 7 (0.06) : Bacteroides | Blautia | Dorea | Lachnospira | Parabacteroides | Roseburia | Veillonella
Non-alcoholic fatty liver disease 0.0529 10 (0.04) : Bacteroides | Citrobacter | Dorea | Enterobacteriaceae | Enterococcus | Escherichia | Lactobacillus | Roseburia | Streptococcus | Veillonella 15 (0.06) : Alistipes | Anaerostipes | Bacteroides | Bacteroides fragilis | Blautia | Citrobacter | Coprococcus | Dorea | Faecalibacterium | Lactobacillus | Odoribacter | Oscillibacter | Parabacteroides | Roseburia | Ruminococcaceae
Severe fever with thrombocytopenia syndrome 0.0528 6 (0.06) : Enterococcus | Escherichia | Lactobacillus | Roseburia | Streptococcus | Veillonella 4 (0.04) : Anaerostipes | Blautia | Faecalibacterium | Lachnospira
Chronic kidney disease 0.0525 14 (0.05) : Acinetobacter | Actinomyces | Bacteroides | Bifidobacterium | Citrobacter | Enterobacteriaceae | Escherichia coli | Lachnoclostridium | Lactobacillus | Marvinbryantia | Paraprevotella | Parasporobacterium | Ruminococcus gnavus | Streptococcus 13 (0.05) : Bacteroides | Bacteroides fragilis | Bifidobacterium | Butyricicoccus | Coprococcus | Dorea | Faecalibacterium | Lachnospira | Oribacterium | Prevotellaceae | Roseburia | Ruminococcaceae | Streptococcus
Alzheimer's disease 0.0517 12 (0.07) : Alistipes | Bacteroides | Bifidobacterium | Blautia | Dorea | Enterobacteriaceae | Escherichia | Lachnoclostridium | Lactobacillus | Propionibacterium | Streptococcus | Veillonellaceae 8 (0.03) : Acinetobacter | Alistipes | Bacteroides | Bacteroides fragilis | Bifidobacterium | Blautia | Lachnospiraceae | Parabacteroides
Postmenopausal 0.0507 3 (0.02) : Bacteroides | Prevotella | Staphylococcus 5 (0.08) : Alistipes | Eubacterium | Faecalibacterium | Lactobacillus | Roseburia
Hypertension 0.0490 8 (0.04) : Actinomyces | Bifidobacterium | Dorea | Enterobacter | Klebsiella | Lactobacillus | Prevotella | Streptococcus 9 (0.06) : Bifidobacterium | Blautia | Coprococcus | Dorea | Faecalibacterium | Odoribacter | Oscillibacter | Roseburia | Veillonella
Ankylosing spondylitis 0.0480 9 (0.04) : Actinomyces | Bifidobacterium | Blautia | Collinsella | Dorea | Escherichia coli | Flavonifractor plautii | Prevotella | Streptococcus 8 (0.05) : Citrobacter | Eubacterium | Fusobacterium | Lachnospira | Odoribacter | Parabacteroides | Prevotellaceae | Roseburia
Chronic urticaria 0.0473 1 (0.01) : Enterobacteriaceae 5 (0.08) : Bacteroides | Bifidobacterium | Faecalibacterium | Lactobacillus | Ruminococcaceae
Gastric carcinoma 0.0467 11 (0.04) : Acinetobacter | Alistipes | Bacteroides | Bifidobacterium | Citrobacter | Haemophilus parainfluenzae | Klebsiella | Lactobacillus | Prevotella | Streptococcus | Veillonella 8 (0.05) : Acinetobacter | Bacteriodes uniformis | Bacteroides | Faecalibacterium | Lachnospira | Neisseria | Roseburia | Streptococcus
Inflamatory bowel disease 0.0459 5 (0.01) : Butyricimonas | Enterobacteriaceae | Enterococcus | Prevotella | Ruminococcus gnavus 12 (0.08) : Alistipes | Anaerostipes | Bacteroides | Bifidobacterium | Blautia | Christensenellaceae | Coprococcus | Dehalobacter | Desulfovibrio | Faecalibacterium | Parabacteroides | Ruminococcaceae
Primary biliary cholangitis 0.0459 8 (0.06) : Citrobacter | Enterobacteriaceae | Klebsiella | Lactobacillales | Lactobacillus | Prevotella | Streptococcus | Veillonella 6 (0.04) : Bacteroides | Blautia | Christensenellaceae | Faecalibacterium | Fusobacterium | Odoribacter
Acquired Immunodeficiency Syndrome 0.0449 4 (0.04) : Enterococcus | Lachnoclostridium | Lactobacillus | Streptococcus 7 (0.05) : Bacteriodes uniformis | Bacteroides stercoris | Bacteroides vulgatus | Blautia | Faecalibacterium | Lachnospira | Roseburia
Non alcoholic steatohepatitis 0.0449 6 (0.03) : Alcaligenaceae | Blautia | Dorea | Escherichia | Lactobacillus | Prevotella 7 (0.06) : Alistipes | Bifidobacterium | Blautia | Coprococcus | Eubacterium | Roseburia | Ruminococcaceae
Asthma 0.0440 11 (0.03) : Actinomyces | Alistipes | Bacteroides | Enterobacteriaceae | Escherichia coli | Klebsiella | Lactobacillus | Odoribacter | Roseburia | Streptococcus | Veillonella 14 (0.06) : Acinetobacter | Anaerovorax | Bifidobacterium | Brevundimonas | Faecalibacterium | Fusobacterium | Lachnospira | Neisseria | Oribacterium | Porphyromonadaceae | Staphylococcus | Streptococcus | Tannerella | Veillonella
Atopic wheeze 0.0439 4 (0.06) : Clostridioides difficile | Ruminococcus gnavus | Streptococcus | Veillonella 2 (0.03) : Bacteroides | Bifidobacterium
Stevens-Johnson syndrome 0.0429 13 (0.08) : Acinetobacter | Bacteroides | Bifidobacterium | Blautia | Collinsella | Lactobacillus | Odoribacter | Paraprevotella | Prevotella | Roseburia | Staphylococcus | Streptococcus | Veillonella 1 (0.00) : Fusibacter
Hirschsprung's disease 0.0427 4 (0.04) : Actinomyces | Dialister | Escherichia | Prevotella 3 (0.05) : Bacteroidales | Lachnospiraceae | Ruminococcaceae
Cholestasis 0.0421 5 (0.03) : Enterobacteriaceae | Enterococcus | Staphylococcus | Streptococcus | Veillonella 7 (0.05) : Anaerostipes | Bacteroides | Bacteroides fragilis | Bifidobacterium | Blautia | Faecalibacterium | Roseburia
Influenza A 0.0409 5 (0.03) : Acinetobacter | Actinomyces | Lachnoclostridium | Lactobacillus | Streptococcus 6 (0.05) : Fusobacterium | Gemella | Haemophilus | Neisseria | Staphylococcus | Streptococcus
Pancreatitis 0.0406 7 (0.04) : Alistipes | Bacteroides | Enterobacteriaceae | Enterococcus | Paraprevotella | Prevotella | Staphylococcus 6 (0.04) : Acinetobacter | Bifidobacterium | Blautia | Brevundimonas | Faecalibacterium | Lachnospiraceae
Primary sclerosing cholangitis 0.0403 7 (0.03) : Bacteroides | Enterococcus | Escherichia coli | Lactobacillus | Staphylococcus | Streptococcus | Veillonella 9 (0.05) : Anaerostipes | Blautia | Christensenellaceae | Coprococcus | Desulfovibrio | Faecalibacterium | Haemophilus | Lachnospiraceae | Parabacteroides
Ischemic stroke 0.0403 2 (0.01) : Enterobacteriaceae | Enterococcus 6 (0.07) : Anaerostipes | Bacteroides | Blautia | Faecalibacterium | Lachnospiraceae | Roseburia
Cirrhosis 0.0402 15 (0.05) : Bacteroides | Dialister | Enterobacter | Enterobacteriaceae | Enterococcus | Escherichia coli | Haemophilus parainfluenzae | Klebsiella | Lactobacillus | Prevotella | Prevotellaceae | Ruminococcus gnavus | Streptococcus | Veillonella | Veillonellaceae 12 (0.03) : Bacteriodes uniformis | Bacteroides | Bifidobacterium | Bifidobacterium catenulatum | Blautia | Dorea | Haemophilus | Lachnospira | Lachnospiraceae | Neisseria | Porphyromonadaceae | Ruminococcaceae
Maturity-onset diabetes of the young 2 0.0392 1 (0.01) : Prevotella 4 (0.06) : Anaerostipes | Faecalibacterium | Lachnospira | Roseburia
Hepatocellular cancer 0.0391 16 (0.07) : Actinomyces | Alistipes | Allisonella | Bacteroides | Collinsella | Dorea | Enterococcus | Erysipelotrichia | Escherichia coli | Holdemania | Lachnospira | Odoribacter | Paraprevotella | Prevotella | Streptococcus | Veillonella 4 (0.01) : Bifidobacterium | Haemophilus | Lactobacillus | Streptococcus
Pancreatic Cancer 0.0377 5 (0.01) : Enterobacter | Klebsiella | Lactobacillus | Prevotella | Veillonella 11 (0.06) : Alistipes | Anaerostipes | Bifidobacterium | Blautia | Brevundimonas | Butyricicoccus | Coprococcus | Dorea | Faecalibacterium | Parabacteroides | Ruminococcaceae
Idiopathic focal epilepsy 0.0363 0 (0.00) 6 (0.07) : Bacteroides | Bifidobacterium | Blautia | Coprococcus | Faecalibacterium | Parabacteroides
Spinal cord injury 0.0358 6 (0.06) : Bacteroides | Blautia | Escherichia coli | Lachnoclostridium | Prevotellaceae | Veillonellaceae 3 (0.02) : Faecalibacterium | Lactobacillus | Roseburia
Multiple Sclerosis 0.0357 11 (0.03) : Actinomyces | Alistipes | Bacteroides | Bifidobacterium | Blautia | Collinsella | Dorea | Holdemania | Lactobacillus | Sporobacter | Streptococcus 10 (0.04) : Bacteroides | Bacteroides stercoris | Blautia | Butyricicoccus | Dorea | Faecalibacterium | Lachnospira | Lachnospiraceae | Roseburia | Ruminococcaceae
Chagas' disease 0.0354 7 (0.07) : Blautia | Enterococcus | Lactobacillus | Peptococcus | Roseburia | Streptococcus | Veillonella 1 (0.00) : Bacteroides
Psoriasis 0.0350 13 (0.03) : Actinomyces | Bacteroides | Bifidobacterium | Blautia | Collinsella | Dialister | Dorea | Enterococcus | Lactobacillales | Prevotella | Ruminococcus gnavus | Staphylococcus | Streptococcus 11 (0.04) : Alistipes | Bacteroides | Coprococcus | Faecalibacterium | Lachnospira | Lachnospiraceae | Lactobacillus | Parabacteroides | Ruminococcaceae | Staphylococcus | Streptococcus
Sjögren syndrome 0.0349 9 (0.03) : Bifidobacterium | Blautia | Dialister | Enterobacter | Escherichia | Lactobacillus | Prevotella | Streptococcus | Veillonella 11 (0.04) : Alistipes | Bacteroides | Bifidobacterium | Blautia | Dorea | Faecalibacterium | Fusobacterium | Haemophilus | Neisseria | Parabacteroides | Roseburia
Neuromyelitis optica 0.0346 3 (0.01) : Bacteroides | Ruminococcus productus | Streptococcus 7 (0.06) : Blautia | Coprococcus | Faecalibacterium | Lachnospiraceae | Lachnospiraceae incertae sedis | Prevotellaceae | Roseburia
Allergy 0.0343 4 (0.03) : Blautia | Dorea | Roseburia | Ruminococcus gnavus 4 (0.04) : Bacteroides | Coprococcus | Lachnospira | Lactobacillus
Hand, foot and mouth disease 0.0342 4 (0.06) : Bifidobacterium | Enterococcus | Escherichia | Streptococcus 2 (0.01) : Dorea | Roseburia
Arsenic exposure 0.0341 3 (0.03) : Blautia | Enterococcus | Streptococcus 4 (0.04) : Bacteroides | Bifidobacterium | Coprococcus | Parabacteroides
Graves' disease 0.0340 1 (0.00) : Prevotella 6 (0.06) : Alistipes | Bifidobacterium | Eubacterium | Faecalibacterium | Lactobacillus | Parabacteroides
Alcoholic Hepatitis 0.0330 8 (0.03) : Actinomyces | Bifidobacterium | Dorea | Enterobacteriaceae | Enterococcus | Lactobacillus | Streptococcus | Veillonella 6 (0.03) : Acinetobacter | Bacteroides | Christensenellaceae | Desulfovibrio | Odoribacter | Parabacteroides
Gestational diabetes 0.0327 10 (0.06) : Actinomyces | Alcaligenaceae | Bacteroides | Collinsella | Enterobacter | Enterococcus | Klebsiella | Leuconostoc | Prevotella | Veillonella 4 (0.01) : Bacteroidales | Lactobacillus | Parabacteroides | Ruminococcaceae
Rheumatoid Arthritis 0.0326 10 (0.02) : Actinomyces | Collinsella | Haemophilus parainfluenzae | Klebsiella | Lactobacillus | Prevotella | Prevotellaceae | Streptococcus | Veillonella | Veillonellaceae 11 (0.04) : Acinetobacter | Bacteroides | Bacteroides fragilis | Bifidobacterium | Brevundimonas | Gemella | Haemophilus | Lachnospira | Roseburia | Staphylococcus | Streptococcus
Generalized anxiety disorder 0.0326 4 (0.02) : Bacteroides | Enterobacteriaceae | Raoultella | Ruminococcus gnavus 8 (0.04) : Acinetobacter | Bacteroides | Butyricicoccus | Coprococcus | Faecalibacterium | Lachnospira | Lachnospiraceae | Ruminococcaceae
Celiac Disease 0.0325 8 (0.02) : Bacteroides | Dorea | Enterobacteriaceae | Escherichia coli | Klebsiella | Lactobacillus | Prevotella | Staphylococcus 10 (0.04) : Acinetobacter | Anaerostipes | Bifidobacterium | Blautia | Clostridium lituseburense | Dorea | Gemella | Lachnospiraceae | Lactobacillus | Staphylococcus
Pulmonary tubercolosis 0.0324 9 (0.04) : Acinetobacter | Collinsella | Escherichia | Escherichia coli | Faecalibacterium prausnitzii | Lactobacillus | Staphylococcus | Streptococcus | Tyzzerella nexilis 7 (0.02) : Collinsella aerofaciens | Coprococcus | Gemella | Lachnospira | Roseburia | Streptococcus | Veillonella
Lung cancer 0.0320 9 (0.05) : Bacteroides | Bifidobacterium | Butyricimonas | Enterobacteriaceae | Enterococcus | Odoribacter | Prevotella | Ruminococcus gnavus | Streptococcus 4 (0.01) : Acinetobacter | Bifidobacterium | Parabacteroides | Streptococcus
Primary Open-Angle Glaucoma 0.0318 4 (0.06) : Enterobacteriaceae | Escherichia coli | Prevotellaceae | Streptococcus 1 (0.01) : Bacteroides plebeius
Hepatitis B 0.0314 8 (0.04) : Actinomyces | Alistipes | Bacteroides | Enterobacteriaceae | Lactobacillus | Prevotella | Streptococcus | Veillonella 5 (0.02) : Alistipes | Anaerostipes | Bacteroides | Bifidobacterium | Parabacteroides
Urogenital Schistosomiasis 0.0310 8 (0.05) : Acinetobacter | Bacteroides | Dialister | Enterococcus | Lactobacillus | Peptococcus | Prevotella | Veillonella 3 (0.01) : Parabacteroides | Ruminococcaceae | Staphylococcus
Rett Syndrome 0.0308 2 (0.02) : Bifidobacterium | Blautia 4 (0.04) : Alistipes | Bacteroides | Faecalibacterium | Streptococcus
Gestational diabetes + hyperlipidemia 0.0303 4 (0.04) : Actinomyces | Prevotella | Streptococcus | Veillonella 1 (0.02) : Faecalibacterium
Fibromyalgia 0.0293 5 (0.02) : Alistipes | Dorea | Flavonifractor plautii | Lachnoclostridium | Roseburia 5 (0.04) : Bacteriodes uniformis | Bacteroides | Bifidobacterium | Eubacterium | Lachnospiraceae
Covid-19 0.0291 4 (0.01) : Actinomyces | Blautia | Streptococcus | Veillonella 7 (0.05) : Anaerostipes | Blautia | Coprococcus | Faecalibacterium | Lachnospiraceae | Roseburia | Ruminococcaceae
Schizophrenia 0.0284 14 (0.04) : Actinomyces | Blautia | Clostridioides difficile | Clostridium symbiosum | Dorea | Enterobacteriaceae | Escherichia | Holdemania | Klebsiella | Lactobacillus | Prevotellaceae | Ruminococcus gnavus | Veillonella | Veillonellaceae 7 (0.02) : Butyricicoccus | Coprococcus | Faecalibacterium | Fusobacterium | Haemophilus | Lachnospiraceae | Ruminococcaceae
Hashimoto's thyroiditis 0.0267 4 (0.02) : Blautia | Dorea | Escherichia coli | Roseburia 4 (0.03) : Bacteroides | Bifidobacterium | Faecalibacterium | Lactobacillus
Chronic Obstructive Pulmonary Disease 0.0259 10 (0.03) : Actinomyces | Aeromonas | Bifidobacterium | Clostridium symbiosum | Dialister | Lactobacillus | Prevotella | Pseudomonas aeruginosa | Streptococcus | Veillonella 8 (0.03) : Acinetobacter | Citrobacter | Gemella | Neisseria | Oribacterium | Staphylococcus | Streptococcus | Veillonella
Hepatitis C 0.0254 7 (0.05) : Acinetobacter | Citrobacter | Escherichia | Lactobacillus | Prevotella | Streptococcus | Veillonella 2 (0.01) : Parabacteroides | Vivictivallis
Diverticular disease 0.0254 2 (0.02) : Alcaligenaceae | Enterobacteriaceae 2 (0.03) : Bacteroides fragilis | Porphyromonadaceae
Polycystic ovary syndrome 0.0251 2 (0.01) : Lactobacillus | Prevotella 6 (0.04) : Bacteroides | Faecalibacterium | Lactobacillus | Oscillibacter | Parabacteroides | Ruminococcaceae
Cutaneous burn 0.0239 3 (0.02) : Enterococcus | Propionibacterium | Staphylococcus 2 (0.03) : Lactobacillus | Streptococcus
Hyperthyroidism 0.0231 1 (0.01) : Enterococcus 2 (0.03) : Bifidobacterium | Lactobacillus
Cardiac valve calcification 0.0231 2 (0.01) : Enterococcus | Lactobacillus 4 (0.04) : Bacteroides | Blautia | Dorea | Ruminococcaceae
Posttreatment Lyme disease syndrome 0.0231 1 (0.01) : Blautia 2 (0.03) : Bacteroides | Roseburia
Chronic fatigue syndrome 0.0229 4 (0.02) : Alistipes | Enterobacteriaceae | Enterococcus | Streptococcus 5 (0.03) : Bacteroides | Bifidobacterium | Eubacterium | Faecalibacterium | Ruminococcaceae
Smoking 0.0229 8 (0.02) : Actinomyces | Bacteroides | Bifidobacterium | Lactobacillus | Prevotella | Staphylococcus | Streptococcus | Veillonella 8 (0.03) : Gemella | Haemophilus | Lactobacillus | Neisseria | Prevotella oralis | Staphylococcus | Streptococcus | Veillonella
Macular degeneration 0.0220 7 (0.04) : Actinomyces | Eubacterium ventriosum | Prevotella | Propionibacterium | Staphylococcus | Streptococcus | Veillonella 1 (0.00) : Fusobacterium
Wiskott-Aldrich syndrome 0.0215 0 (0.00) 4 (0.04) : Alistipes | Bacteroides | Faecalibacterium | Parabacteroides
Hepatic encephalopathy 0.0214 5 (0.02) : Bifidobacterium | Enterobacteriaceae | Enterococcus | Lactobacillales | Veillonella 4 (0.02) : Faecalibacterium | Lachnospiraceae | Prevotellaceae | Roseburia
Uveitits 0.0212 4 (0.02) : Paraprevotella | Prevotella | Streptococcus | Veillonella 8 (0.03) : Bacteroides | Blautia | Dorea | Faecalibacterium | Lachnospira | Lachnospiraceae incertae sedis | Odoribacter | Roseburia
Atrophic gastritis 0.0210 2 (0.02) : Bacteroides | Enterobacteriaceae 4 (0.02) : Faecalibacterium | Lachnospiraceae | Prevotella tannerae | Roseburia
Atherosclerosis 0.0205 6 (0.03) : Collinsella | Enterobacteriaceae | Escherichia coli | Klebsiella | Ruminococcus gnavus | Streptococcus 3 (0.01) : Bacteroides | Eubacterium | Roseburia
Colon polyps 0.0201 2 (0.00) : Faecalibacterium prausnitzii | Ruminococcus gnavus 3 (0.04) : Collinsella aerofaciens | Fusobacterium | Lactobacillus
Thyroid carcinoma 0.0200 7 (0.03) : Alistipes | Blautia | Klebsiella | Lactobacillus | Prevotella | Roseburia | Streptococcus 3 (0.01) : Bacteroides | Christensenellaceae | Roseburia
Infantile eczema 0.0198 4 (0.01) : Enterobacter | Paraprevotella | Roseburia | Veillonella 7 (0.03) : Bifidobacterium | Butyricicoccus | Dorea | Haemophilus | Lactobacillus | Oscillibacter | Streptococcus
Acne 0.0198 6 (0.02) : Bacteroides | Enterobacteriaceae | Enterococcus | Klebsiella | Odoribacter | Staphylococcus 6 (0.02) : Bifidobacterium | Blautia | Butyricicoccus | Lachnospira | Lachnospiraceae incertae sedis | Lactobacillus
Spondyloarthritis 0.0193 4 (0.03) : Bifidobacterium | Dialister | Dorea | Ruminococcus gnavus 2 (0.01) : Lachnospiraceae | Roseburia
Anovulation 0.0191 3 (0.02) : Dialister | Peptococcus | Prevotella 3 (0.01) : Anaerostipes | Lachnospiraceae | Roseburia
Invasive colorectal cancer 0.0191 1 (0.00) : Enterococcus 3 (0.04) : Desulfovibrio | Lactobacillus | Oribacterium
Juvenile idiopathic arthritis 0.0190 5 (0.03) : Dorea | Faecalibacterium prausnitzii | Haemophilus parainfluenzae | Klebsiella | Veillonellaceae 2 (0.01) : Blautia | Gemella
Radiation enteritis 0.0184 1 (0.00) : Prevotella 2 (0.03) : Bacteroides | Blautia
Osteoporosis 0.0182 4 (0.02) : Actinomyces | Bacteroides | Blautia | Lactobacillus 1 (0.02) : Roseburia
Interstitial cystitis 0.0182 3 (0.02) : Bacteroides | Bifidobacterium | Enterococcus 5 (0.02) : Coprococcus | Eubacterium | Faecalibacterium | Lactobacillus | Streptococcus
Reactive arthritis 0.0181 0 (0.00) 3 (0.04) : Blautia | Coprococcus | Roseburia
Collagenous colitis 0.0179 1 (0.00) : Bacteroides 4 (0.03) : Alistipes | Coprococcus | Oscillibacter | Ruminococcaceae
Rectal Carcinoma 0.0177 2 (0.01) : Bacteroides | Odoribacter 3 (0.02) : Acinetobacter | Bifidobacterium | Lactobacillus
Gingivitis 0.0177 1 (0.01) : Streptococcus 2 (0.02) : Streptococcus | Veillonella
T2D with hypertension and hyperlipidemia 0.0177 1 (0.01) : Prevotella 2 (0.02) : Acinetobacter | Gemella
Bladder cancer 0.0173 2 (0.00) : Acinetobacter | Aeromonas 6 (0.03) : Bacteroides | Bifidobacterium | Lactobacillus | Ruminococcaceae | Streptococcus | Veillonella
Bipolar disorder 0.0168 1 (0.00) : Bacteroides 4 (0.03) : Coprococcus | Faecalibacterium | Roseburia | Ruminococcaceae
Pervasive developmental disorder NOS 0.0168 3 (0.01) : Collinsella | Dorea | Faecalibacterium prausnitzii 6 (0.03) : Bacteriodes uniformis | Bacteroides ovatus | Bacteroides vulgatus | Coprococcus eutactus | Fusobacterium | Parabacteroides
Chronic pancreatitis 0.0167 1 (0.00) : Dialister 4 (0.03) : Butyricicoccus | Dorea | Faecalibacterium | Lachnospiraceae
Primary liver cancer 0.0164 4 (0.02) : Enterobacter | Enterococcus | Escherichia coli | Ruminococcus gnavus 1 (0.01) : Prevotellaceae
Invasive pneumococcal disease 0.0164 5 (0.02) : Acinetobacter | Actinomyces | Prevotella | Streptococcus | Veillonella 1 (0.01) : Staphylococcus
Heart failure 0.0163 4 (0.02) : Enterococcus | Lactobacillus | Streptococcus | Veillonella 3 (0.01) : Butyricicoccus | Dorea | Oscillibacter
Amyotrophic lateral sclerosis 0.0154 3 (0.01) : Escherichia coli | Odoribacter | Sporobacter 3 (0.02) : Bacteroides | Dorea | Faecalibacterium
Myasthenia gravis 0.0153 4 (0.02) : Acinetobacter | Bacteroides | Escherichia | Streptococcus 3 (0.01) : Butyricicoccus | Eubacterium | Lactobacillus
Infective colitis 0.0150 1 (0.01) : Bacteroides 2 (0.02) : Bifidobacterium | Blautia coccoides
Aphthous ulcer 0.0150 2 (0.00) : Lactobacillus | Prevotella 4 (0.03) : Gemella | Haemophilus | Streptococcus | Veillonella
Idiopathic Pulmonary Fibrosis 0.0150 4 (0.02) : Blautia | Prevotella | Streptococcus | Veillonella 2 (0.01) : Coprococcus | Dorea
Rhinovirus infection 0.0150 1 (0.01) : Propionibacterium 1 (0.02) : Neisseria
Behcet's Disease 0.0147 4 (0.01) : Bifidobacterium | Haemophilus parainfluenzae | Paraprevotella | Streptococcus 7 (0.02) : Alistipes | Coprococcus | Eubacterium | Lachnospiraceae | Neisseria | Roseburia | Veillonella
Systemic sclerosis 0.0146 4 (0.02) : Bifidobacterium | Citrobacter | Lactobacillus | Prevotella 2 (0.01) : Faecalibacterium | Staphylococcus
Primary biliary cirrhosis 0.0145 5 (0.03) : Enterobacteriaceae | Haemophilus parainfluenzae | Klebsiella | Streptococcus | Veillonella 0 (0.00)
Psychogenic erectile dysfunction 0.0145 0 (0.00) 3 (0.03) : Blautia | Lachnospiraceae | Roseburia
Preeclamsia 0.0140 6 (0.02) : Blautia | Dialister | Enterobacteriaceae | Escherichia | Prevotella | Veillonella 2 (0.01) : Faecalibacterium | Lachnospira
Aerobic vaginitis 0.0139 10 (0.03) : Candidatus saccharibacteria bacterium | Dialister | Enterococcus | Escherichia | Escherichia coli | Faecalibacterium prausnitzii | Raoultella | Staphylococcus | Streptococcus | Veillonella 1 (0.00) : Lactobacillus
Bacterial vaginosis 0.0136 10 (0.03) : Acinetobacter | Actinomyces | Allisonella | Citrobacter | Dialister | Lachnospira | Papillibacter | Prevotella | Streptococcus | Veillonella 1 (0.00) : Lactobacillus
Cirrhosis with pneumonia 0.0136 2 (0.01) : Actinomyces | Bacteroides 1 (0.02) : Streptococcus
Sickle cell disease 0.0134 1 (0.01) : Escherichia 2 (0.01) : Alistipes | Faecalibacterium
Dry eye syndrom 0.0133 2 (0.01) : Prevotella | Veillonella 2 (0.02) : Faecalibacterium | Veillonella
Recurrent miscarriage 0.0133 2 (0.02) : Prevotella | Streptococcus 1 (0.01) : Lactobacillus
Bleeding gum 0.0133 1 (0.00) : Prevotella 3 (0.02) : Haemophilus | Streptococcus | Veillonella
Aggressive periodontitis 0.0128 2 (0.00) : Prevotella | Veillonella 9 (0.02) : Bacteroides | Bifidobacterium | Faecalibacterium | Gemella | Haemophilus | Lachnospiraceae | Oribacterium | Streptococcus | Veillonella
Clonorchis sinensis infection 0.0128 1 (0.00) : Dorea 3 (0.02) : Bacteroides | Parabacteroides | Veillonella
Silicosis 0.0122 2 (0.01) : Dialister | Lachnoclostridium 3 (0.01) : Bacteroides | Bifidobacterium | Blautia
Depression 0.0120 2 (0.01) : Lactobacillus | Prevotellaceae 2 (0.02) : Bacteroides fragilis | Coprococcus
COPD Exacerbation 0.0117 1 (0.00) : Acinetobacter 4 (0.02) : Gemella | Lachnospiraceae | Ruminococcaceae | Streptococcus
Helicobacter pylori infection 0.0116 4 (0.01) : Acinetobacter | Butyricimonas | Enterococcus | Oxalobacter 4 (0.01) : Bacteroides vulgatus | Fusobacterium | Roseburia | Streptococcus
Infant colic 0.0115 1 (0.01) : Acinetobacter 1 (0.02) : Bifidobacterium
Urolithiasis 0.0115 1 (0.01) : Enterobacteriaceae 1 (0.02) : Lactobacillus
Acute lymphoblastic leukemia 0.0115 1 (0.00) : Bacteroides 4 (0.02) : Alistipes | Bifidobacterium | Faecalibacterium | Staphylococcus
Chronic Rhinosinusitis 0.0113 2 (0.00) : Escherichia | Pseudomonas aeruginosa 5 (0.02) : Bacteroides | Lachnospiraceae | Lactobacillus | Parabacteroides | Ruminococcaceae
Necrotizing enterocolitis 0.0111 4 (0.02) : Citrobacter | Enterobacter | Enterococcus | Escherichia coli 0 (0.00)
Intrahepatic Cholangiocarcinoma 0.0110 2 (0.01) : Actinomyces | Lactobacillus 1 (0.01) : Lachnospira
Liver transplant 0.0108 0 (0.00) 2 (0.02) : Bifidobacterium | Lactobacillus
Severe congenital neutropenia 0.0108 0 (0.00) 2 (0.02) : Fusobacterium | Haemophilus
Keratitis 0.0106 1 (0.00) : Dorea 5 (0.02) : Bacteroides plebeius | Dorea | Faecalibacterium | Lachnospira | Roseburia
Seminal hyperviscosity 0.0104 1 (0.00) : Klebsiella 1 (0.02) : Lactobacillus
Oligoasthenoteratozoospermia 0.0104 1 (0.00) : Klebsiella 1 (0.02) : Lactobacillus
Systemic lupus erythematosus 0.0102 8 (0.02) : Actinomyces | Dialister | Klebsiella | Lactobacillales | Lactobacillus | Prevotella | Ruminococcus gnavus | Veillonellaceae 2 (0.00) : Bifidobacterium | Roseburia
Anorexia nervosa 0.0102 2 (0.01) : Enterobacteriaceae | Enterococcus 2 (0.01) : Roseburia | Streptococcus
Pneumonia 0.0102 2 (0.01) : Prevotella | Veillonella 2 (0.01) : Acinetobacter | Streptococcus
T2D with hypertension 0.0102 2 (0.02) : Aeromonas | Roseburia 1 (0.00) : Lactobacillus
Posttraumatic stress syndrome 0.0102 1 (0.00) : Streptococcus 3 (0.02) : Anaerostipes | Lachnospira | Roseburia
Kidney stone 0.0099 3 (0.01) : Acinetobacter | Alistipes | Bacteroides 4 (0.01) : Anaerostipes | Dorea | Faecalibacterium | Lactobacillus
Transient Ischemic Attack 0.0098 3 (0.01) : Alistipes | Enterobacter | Lactobacillus 2 (0.01) : Bacteroides | Faecalibacterium
Fibrosis 0.0098 1 (0.00) : Streptococcus 2 (0.02) : Bacteroides | Coprococcus
Colon adenomas 0.0096 2 (0.00) : Dorea | Veillonella 4 (0.02) : Bacteroides | Butyricicoccus | Coprococcus | Oscillibacter
Osmotic diarrhea 0.0096 1 (0.01) : Acinetobacter 1 (0.01) : Alistipes
Wilson's Disease 0.0096 2 (0.01) : Bacteroides | Lachnospira 1 (0.01) : Roseburia
Tongue cancer 0.0096 3 (0.02) : Actinomyces | Enterococcus | Streptococcus 2 (0.00) : Fusobacterium | Gemella
Liver fibrosis 0.0095 1 (0.00) : Prevotella 2 (0.02) : Lachnospiraceae | Ruminococcaceae
Vulvar vestibulitis syndrome 0.0093 2 (0.02) : Enterococcus | Streptococcus 0 (0.00)
Prediabetes 0.0093 2 (0.02) : Dorea | Streptococcus 0 (0.00)
Cervical intraneoplasia 0.0093 2 (0.02) : Lactobacillus | Staphylococcus 0 (0.00)
Melanoma 0.0092 1 (0.00) : Bifidobacterium 1 (0.02) : Faecalibacterium
Halitosis 0.0091 3 (0.00) : Dialister | Peptococcus | Prevotella 3 (0.01) : Gemella | Oribacterium | Streptococcus
Multiple system atrophy 0.0091 2 (0.01) : Bacteroides | Lactobacillus 3 (0.01) : Bacteroides plebeius | Blautia | Haemophilus
Cystic fibrosis exacerbation 0.0091 0 (0.00) 3 (0.02) : Haemophilus | Staphylococcus | Streptococcus
Constipation 0.0088 3 (0.01) : Acinetobacter | Blautia | Enterococcus 2 (0.01) : Blautia | Odoribacter
Oral cancer 0.0087 6 (0.01) : Actinomyces | Enterobacteriaceae | Lactobacillus | Prevotella | Streptococcus | Veillonella 3 (0.00) : Haemophilus | Oribacterium | Streptococcus
Breast cancer 0.0086 5 (0.01) : Actinomyces | Alcaligenaceae | Alistipes | Enterobacteriaceae | Staphylococcus 2 (0.00) : Streptococcus | Veillonella
Vaginal Chlamydiosis 0.0083 6 (0.02) : Collinsella | Dialister | Lactobacillus | Prevotella | Streptococcus | Veillonella 0 (0.00)
Exacerbations of idiopathic pulmonary fibrosis 0.0081 0 (0.00) 1 (0.02) : Veillonella
Meningococcal disease 0.0081 0 (0.00) 1 (0.02) : Veillonella
Autoimmune Thyroid Disorders 0.0081 0 (0.00) 2 (0.02) : Bifidobacterium | Lactobacillus
Otitis Media 0.0078 4 (0.01) : Klebsiella | Prevotella | Streptococcus | Veillonella 2 (0.00) : Acinetobacter | Streptococcus
Attention Deficit Hyperactivity Disorder 0.0078 1 (0.00) : Bifidobacterium 3 (0.01) : Faecalibacterium | Lachnospiraceae | Lactobacillus
Oral lichen planus 0.0076 1 (0.00) : Prevotella 4 (0.01) : Bacteroides | Haemophilus | Neisseria | Streptococcus
Diarrhea 0.0075 1 (0.01) : Bacteroides 1 (0.01) : Bifidobacterium
Head/Neck cancer 0.0073 0 (0.00) 3 (0.01) : Fusobacterium | Lachnospiraceae | Tannerella
Obstructive sleep apnea-hypopnea syndrome 0.0072 3 (0.01) : Prevotella | Streptococcus | Veillonella 3 (0.01) : Bifidobacterium | Oscillibacter | Ruminococcaceae
Iron-deficiency anaemia 0.0072 2 (0.01) : Enterococcus | Lactobacillus 1 (0.00) : Neisseria
Barrett's oesophagus 0.0071 1 (0.00) : Veillonella 2 (0.01) : Gemella | Streptococcus
Kidney stone with hypertension 0.0071 3 (0.01) : Anaerovorax | Lactobacillus | Propionibacterium 2 (0.00) : Butyricicoccus | Lachnospiraceae incertae sedis
Human end-stage renal disease 0.0070 1 (0.00) : Flavonifractor plautii 3 (0.01) : Bifidobacterium | Lachnospira | Roseburia
Migraine 0.0069 4 (0.01) : Clostridium symbiosum | Flavonifractor plautii | Ruminococcus gnavus | Streptococcus 0 (0.00)
Chronic Rhinosinusitis with cystic fibrosis 0.0069 2 (0.01) : Propionibacterium | Streptococcus 0 (0.00)
Shiga Toxin-producing E. coli infection 0.0069 1 (0.01) : Lactobacillales 0 (0.00)
Cleft palate 0.0069 1 (0.01) : Streptococcus 0 (0.00)
Giardia intestinalis infection 0.0069 1 (0.01) : Prevotella 0 (0.00)
Anti-N-methyl-D-aspartate receptor encephalitis 0.0069 2 (0.01) : Bacteroides | Streptococcus 0 (0.00)
Chronic mucocutaneous candidiasis 0.0069 1 (0.01) : Acinetobacter 0 (0.00)
Hyper IgE syndrome 0.0069 1 (0.01) : Acinetobacter 0 (0.00)
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy 0.0069 2 (0.01) : Lachnospira | Odoribacter 0 (0.00)
Pressure ulcers 0.0069 4 (0.01) : Bacteroides | Dorea | Enterococcus | Ruminococcus gnavus 0 (0.00)
Nasolacrimal duct obstruction 0.0069 1 (0.01) : Staphylococcus 0 (0.00)
Preterm birth 0.0068 3 (0.01) : Prevotella | Streptococcus | Veillonella 1 (0.00) : Bacteroides
Caries 0.0068 7 (0.01) : Acinetobacter | Actinomyces | Lactobacillus | Prevotella | Streptococcus | Veillonella | Veillonellaceae 5 (0.01) : Fusobacterium | Haemophilus | Lachnospiraceae | Neisseria | Streptococcus
Graves' orbitopathy 0.0066 0 (0.00) 3 (0.01) : Anaerostipes | Blautia | Butyricicoccus
Eosinophilic esophagitis 0.0065 0 (0.00) 2 (0.01) : Lactobacillus | Streptococcus
Chronic Laryngitis 0.0064 1 (0.01) : Streptococcus 2 (0.01) : Neisseria | Staphylococcus
Frailty 0.0063 1 (0.00) : Dorea 1 (0.01) : Lachnospiraceae
Protracted bacterial bronchitis 0.0057 3 (0.01) : Bifidobacterium | Enterococcus | Prevotella 1 (0.01) : Lactobacillus
Acute fatty liver 0.0056 2 (0.01) : Acinetobacter | Enterococcus 1 (0.00) : Blautia
Excessive vomiting 0.0056 2 (0.01) : Acinetobacter | Enterococcus 1 (0.00) : Blautia
Chronic stress 0.0056 2 (0.01) : Bacteroides | Roseburia 0 (0.00)
Fatigue 0.0055 1 (0.01) : Ruminococcus gnavus 1 (0.00) : Alistipes
Tetratricopeptide repeat domain 7A deficiency 0.0054 1 (0.00) : Enterobacteriaceae 1 (0.01) : Ruminococcaceae
Mucosa-associated lymphoid tissue lymphoma 0.0052 0 (0.00) 3 (0.01) : Bacteroides | Lactobacillus | Parabacteroides
Microscopic colitis 0.0051 1 (0.00) : Haemophilus parainfluenzae 3 (0.01) : Christensenellaceae | Coprococcus | Staphylococcus
Genitourinary lichen sclerosus 0.0050 1 (0.00) : Lactobacillus 1 (0.01) : Staphylococcus
H7N9 0.0049 1 (0.00) : Bacteroides 1 (0.01) : Haemophilus
Endometriosis 0.0048 4 (0.01) : Acinetobacter | Enterobacteriaceae | Prevotella | Streptococcus 1 (0.00) : Gemella
Urgency urinary incontinence 0.0046 1 (0.00) : Staphylococcus 1 (0.01) : Lactobacillus
Common Variable Immunodeficieny 0.0046 2 (0.01) : Enterobacteriaceae | Streptococcus 0 (0.00)
Kawasaki disease 0.0045 2 (0.01) : Blautia | Roseburia 1 (0.00) : Staphylococcus
Laryngeal carcinoma 0.0043 3 (0.01) : Dialister | Prevotella | Staphylococcus 1 (0.00) : Streptococcus
Autoimmune polyendocrine syndrome type 1 0.0043 0 (0.00) 4 (0.01) : Bacteroides | Desulfovibrio | Lachnospiraceae | Ruminococcaceae
Kaposi's sarcoma 0.0043 1 (0.00) : Dialister 1 (0.00) : Gemella
Stomach cancer 0.0040 0 (0.00) 1 (0.01) : Oscillibacter
Bronchiectasis 0.0040 0 (0.00) 1 (0.01) : Haemophilus
Neuro-Behcet's disease 0.0040 0 (0.00) 1 (0.01) : Lachnospiraceae
Pregnancy 0.0039 1 (0.00) : Streptococcus 3 (0.01) : Ruminococcaceae | Streptococcus | Veillonella
Alopecia areata 0.0038 1 (0.00) : Propionibacterium 1 (0.01) : Staphylococcus
Coronary Heart Disease 0.0036 0 (0.00) 2 (0.01) : Citrobacter | Parabacteroides
Sicca syndrome 0.0036 2 (0.00) : Actinomyces | Prevotella 2 (0.00) : Neisseria | Streptococcus
Urinary stone disease 0.0035 1 (0.01) : Lactobacillales 0 (0.00)
Atrial fibrilation 0.0035 1 (0.01) : Alcaligenaceae 0 (0.00)
Conjunctival scarring 0.0035 1 (0.01) : Streptococcus 0 (0.00)
Botulism 0.0035 1 (0.01) : Enterobacteriaceae 0 (0.00)
Chronic rhinosinusitis with nasal polyps 0.0035 1 (0.01) : Haemophilus parainfluenzae 0 (0.00)
Overactive bladder 0.0035 1 (0.00) : Staphylococcus 2 (0.00) : Fusobacterium | Lactobacillus
Intestinal metaplasia 0.0035 2 (0.01) : Leuconostoc | Streptococcus 0 (0.00)
Laryngotracheal stenosis 0.0035 1 (0.01) : Acinetobacter 0 (0.00)
Pulmonary arterial hypertension 0.0033 1 (0.00) : Ruminococcus gnavus 2 (0.00) : Bacteroides intestinalis | Coprococcus eutactus
Metabolic syndrome 0.0032 0 (0.00) 2 (0.01) : Bifidobacterium | Desulfovibrio
Pancreatic head cancer 0.0025 1 (0.00) : Actinomyces 1 (0.00) : Haemophilus
Refractory celiac disease 0.0023 1 (0.00) : Streptococcus intermedius 0 (0.00)
Cervicitis 0.0023 1 (0.00) : Prevotella 0 (0.00)
Allergic asthma 0.0023 1 (0.00) : Bifidobacterium 0 (0.00)
Pemphigus vulgaris 0.0023 1 (0.00) : Collinsella 0 (0.00)
Periodontal disease 0.0022 2 (0.00) : Prevotella | Veillonellaceae 2 (0.00) : Haemophilus | Streptococcus
Oropharyngeal cancer 0.0022 1 (0.00) : Haemophilus parainfluenzae 1 (0.00) : Prevotella tannerae
Hypopharyngeal cancer 0.0022 1 (0.00) : Haemophilus parainfluenzae 1 (0.00) : Prevotella tannerae
Seborrheic dermatitis 0.0021 1 (0.00) : Staphylococcus 1 (0.00) : Bacteroides
Alcoholic cirrhosis 0.0020 1 (0.00) : Staphylococcus 1 (0.00) : Alistipes
Idiopathic central precocious puberty 0.0020 2 (0.00) : Acinetobacter | Holdemania 0 (0.00)
Azoospermia 0.0019 0 (0.00) 2 (0.00) : Coprococcus | Desulfovibrio
Cervical cancer 0.0017 2 (0.00) : Dorea | Roseburia 0 (0.00)
Blepharitis 0.0017 1 (0.00) : Staphylococcus 0 (0.00)
Bullous pemphigoid 0.0017 1 (0.00) : Staphylococcus 0 (0.00)
Vogt-Koyagani-Harada disease 0.0017 1 (0.00) : Alternaria alternata 0 (0.00)
Hemodialysis with Normal Weight Obesity 0.0016 0 (0.00) 1 (0.00) : Coprococcus
Esophageal cancer 0.0014 1 (0.00) : Enterobacteriaceae 0 (0.00)
Opisthorchis felineus infection 0.0014 2 (0.00) : Faecalibacterium prausnitzii | Haemophilus parainfluenzae 0 (0.00)
Idiopathic infertility 0.0014 1 (0.00) : Veillonella 0 (0.00)
Chronic prostatitis - Chronic pelvic pain syndrome 0.0013 0 (0.00) 1 (0.00) : Porphyromonadaceae
Adolescent idiopathic scoliosis 0.0013 0 (0.00) 1 (0.00) : Bacteroides fragilis
Hepatitis B associated liver failure 0.0013 0 (0.00) 1 (0.00) : Bacteroides fragilis
Prostate cancer 0.0012 1 (0.00) : Escherichia 0 (0.00)
Recurrent tonsillitis 0.0012 1 (0.00) : Streptococcus intermedius 1 (0.00) : Oribacterium
Hidradenitis suppurativa 0.0012 1 (0.00) : Prevotellaceae 0 (0.00)

[Overlap Factors (Causality ?)]

FactorOverlapCommon increased OrganismCommon decreased Organism
Exposure to Glyphosate 0.0286 3 (0.02) : Actinomyces | Prevotella | Veillonella 3 (0.04) : Butyricicoccus | Lactobacillus | Streptococcus
Consumption of Coffee 0.0278 6 (0.06) : Alistipes | Bifidobacterium | Blautia | Dialister | Odoribacter | Roseburia 0 (0.00)
High Water drinking 0.0177 1 (0.01) : Dorea 2 (0.02) : Bacteroides | Odoribacter
Cannabis smoking 0.0173 2 (0.02) : Actinomyces | Streptococcus 1 (0.02) : Neisseria
Aging 0.0161 0 (0.00) 2 (0.03) : Bifidobacterium | Faecalibacterium
Heat Stress 0.0161 0 (0.00) 2 (0.03) : Bacteroides | Lactobacillus
Low FODMAP diet 0.0150 1 (0.01) : Bacteroides 1 (0.02) : Bifidobacterium
Protein powder consumption 0.0143 0 (0.00) 4 (0.03) : Blautia | Coprococcus | Lachnospiraceae | Roseburia
High salt diet 0.0115 1 (0.01) : Bifidobacterium 1 (0.02) : Lactobacillus
Oral administration of Metformin 0.0104 0 (0.00) 3 (0.02) : Dorea | Lactobacillus | Roseburia
Antibiotic Therapy 0.0093 2 (0.02) : Enterobacteriaceae | Lactobacillales 0 (0.00)
Mediterranean diet 0.0093 2 (0.02) : Faecalibacterium prausnitzii | Roseburia 0 (0.00)
Sugar intake 0.0081 0 (0.00) 1 (0.02) : Lactobacillus
High Socio-economic status 0.0081 0 (0.00) 1 (0.02) : Bacteroides
Maternal Antibiotic Exposure 0.0040 0 (0.00) 1 (0.01) : Bifidobacterium
Grape powder consumption 0.0040 0 (0.00) 1 (0.01) : Bifidobacterium
Curcumin Supplementation 0.0035 1 (0.01) : Lachnoclostridium 0 (0.00)
Milk Formula-feeding 0.0017 1 (0.00) : Bacteroides 0 (0.00)

[Reverse Overlap Factors (Curability ?)]

FactorOverlapIncrease decreased Org/DisDecrease increased Org/Dis
High Socio-economic status 0.0358 4 (0.06) : Anaerostipes | Eubacterium | Faecalibacterium | Lachnospiraceae 1 (0.02) : Bacteroides
Consumption of Coffee 0.0278 6 (0.06) : Alistipes | Bifidobacterium | Blautia | Faecalibacterium | Odoribacter | Roseburia 0 (0.00)
Exposure to Glyphosate 0.0185 3 (0.02) : Fusobacterium | Parabacteroides | Veillonella 2 (0.02) : Lactobacillus | Streptococcus
High Water drinking 0.0177 1 (0.01) : Dorea 2 (0.02) : Bacteroides | Odoribacter
Heat Stress 0.0161 0 (0.00) 2 (0.03) : Bacteroides | Lactobacillus
Grape powder consumption 0.0161 0 (0.00) 2 (0.03) : Bifidobacterium | Dialister
Low FODMAP diet 0.0150 1 (0.01) : Bacteroides 1 (0.02) : Bifidobacterium
Mediterranean diet 0.0119 2 (0.02) : Lachnospiraceae | Roseburia 1 (0.01) : Ruminococcus gnavus
Sugar intake 0.0115 1 (0.01) : Bacteroides fragilis 1 (0.02) : Lactobacillus
High salt diet 0.0115 1 (0.01) : Bifidobacterium 1 (0.02) : Lactobacillus
Oral administration of Metformin 0.0111 1 (0.00) : Ruminococcaceae 3 (0.02) : Dorea | Lactobacillus | Roseburia
Probiotic (Bifidobacter and Lactobacilus) 0.0081 0 (0.00) 1 (0.02) : Enterobacteriaceae
Protein powder consumption 0.0081 0 (0.00) 3 (0.02) : Blautia | Lactobacillales | Roseburia
Aging 0.0040 0 (0.00) 1 (0.01) : Bifidobacterium
Maternal Antibiotic Exposure 0.0040 0 (0.00) 1 (0.01) : Bifidobacterium
Curcumin Supplementation 0.0040 0 (0.00) 1 (0.01) : Escherichia
Cannabis smoking 0.0023 1 (0.00) : Streptococcus 0 (0.00)
Antibiotic Therapy 0.0020 0 (0.00) 1 (0.00) : Lactobacillales
Milk Formula-feeding 0.0017 1 (0.00) : Bacteroides 0 (0.00)

Common References