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Systemic lupus erythematosus {40000134}

Record Keys


Definition:
Systemic lupus erythematosus
Class:[  ]

Details


Other Terms:
SLE , Lupus
Initialisation date:
2020-09-13

Links


Meta Information


ICD:[  ]
Category:
Rheumatology, Immunology
MedDra ID:
10042945
MedDra Level:
pt

Notes


- Mice with lupus had decreased amounts of Lactobacillus.
- The lupus mice had a "leaky gut" a condition that affects the intestinal lining.
- Addition of Lactobacillus to the diet only affected female mice and not males. (1)

- Women diagnosed with SLE had roughly five times more gut bacteria known as Ruminococcus gnavus.
- New treatments could also be used to promote growth of Bacteroides uniformis, bacteria thought to hinder growth of R. gnavus in the gut and whose numbers decreased by as much as fourfold in study participants with lupus when compared to those without the disease.
- Women diagnosed with SLE had roughly five times more gut bacteria known as Ruminococcus gnavus, than 17 women of similar ages and racial backgrounds who did not have the disease and were healthy.
- Disease "flares," which can range from instances of skin rash and joint pain to severe kidney dysfunction requiring dialysis, closely tracked major increases in R. gnavus bacterial growth in the gut, alongside the presence in blood samples of immune proteins called antibodies, specifically shaped to attach to the bacteria. Study participants with kidney flares had especially high levels of antibodies to R. gnavus.
- Strong immune antibody reactions to R. gnavus in the blood because the gut lining prevents the bacterium from escaping to other parts of the body. Researchers say this suggests that small pieces of the bacteria, known as antigens, must have "leaked" into the gut to trigger the immune reaction. (3)

Shared Notes


  • [1.12
    - Vancomycin-treated mice showed an increase in Lactobacillus animalis in the gut, whereas there was a depletion in the total gut bacterial load.
    - Oral administration of L. animalis led to an exacerbation of lupus postpartum consisting of worsened splenomegaly and proteinuria while this did not affect the course of the disease in mice that were not pregnant or lactating.
    - L. animalis acted by inhibiting the serum enzyme indoleamine 2,3-dioxygenase alongside a differential production of immunosuppressive and pro-inflammatory mediators in the postpartum period.
    - The enriched L. animalis was involved in the vancomycin-driven effects on decreased T regulatory cells and increased pro-inflammatory cytokines.
    - Many Lupus patients have little or no detectable perturbations in representation of the Lachnospiraceae family or abundance of Ruminococcus gnavus species overtime.
  • [1.13
    - Anti-RG antibodies correlated directly with SLEDAI score and antinative DNA levels, but inversely with C3 and C4.
    - Intestinal expansions of Ruminococcus gnavus were directly proportional to overall disease activity and most pronounced in those with lupus nephritis.
    - Lupus faecal samples displayed increases in sIgA-coated Ruminococcus gnavus bacteria.
    - Patients with lupus nephritis displayed elevated serum IgG predominantly to Ruminococcus gnavus strain-restricted cell wall lipoglycan antigens.
  • [1.3
    - Bacilli and Lactobacillales were positively correlated with the risk of SLE.
    - Bacillales, Coprobacter and Lachnospira were negatively correlated with SLE risk.
    - Bacilli, Lactobacillales, and Eggerthella were risk factors for SLE.
    - Bacillales and Coprobacter served as protective factors for SLE.
    - Ruminiclostridium was negatively associated with SLE.
    - Actinobacteria might reduce the SLE risk.


[Overlap other Diseases]

DiseaseOverlapCommon increased OrganismCommon decreased Organism
Systemic lupus erythematosus 1.0000 48 (1.00) : Actinomyces | Aggregatibacter actinomycetemcomitans | Bacilli | Bacteriodes uniformis | Bacteroides ovatus | Bacteroides thetaiotaomicron | Bacteroides uniformis | Bacteroides vulgatus | Bacteroidetes | Blautia caecimuris | Blautia faecis | Blautia wexlerae | Campylobacter | Corynebacterium | Deinococcus | Dialister | Eggerthella | Eubacterium | Flavonifractor | Fretibacterium fastidiosum | Fusobacterium | Klebsiella | Lachnospiraceae | Lactobacillaceae | Lactobacillales | Lactobacillus | Lactobacillus animalis | Lactobacillus mucosae | Megasphaera | Moraxellaceae | Prevotella | Prevotella nigrescens | Prevotella oris | Prevotella oulorum | Prevotella pleuritidis | Pseudomonas | Rhodococcus | Rothia | Ruminococcus gnavus | Selenomonas noxia | Staphylococcus aureus | Staphylococcus epidermidis | Staphylococcus hominis | Staphylococcus warneri | Streptococcus anginosus | Treponema maltophilum | Veillonella dispar | Veillonellaceae 33 (1.00) : Acidobacteria | Alistipes finegoldii | Alistipes ihumii | Alistipes indistinctus | Alistipes obesi | Alistipes onderdonkii | Alistipes shahii | Bacteroides uniformis | Bifidobacterium | Capnocytophaga gingivalis | Clostridium | Cutibacterium | Erwinia mallotivora | Faecalibacterium prausnitzii | Haemophilus parainfluenzae | Halomonas | Klebsiella pneumoniae | Leptotrichia | Micrococcaceae | Odoribacter laneus | Odoribacter splanchnicus | Peptostreptococcaceae | Prevotella | Pseudobutyrivibrio | Ralstonia | Rhodococcus erythropolis | Roseburia | Rothia aeria | Sphingomonadaceae | Sphingomonas | Streptococcus sanguinis | Tenericutes | Xanthomonadaceae
Cirrhosis 0.0431 14 (0.07) : Bacteroides vulgatus | Dialister | Eubacterium | Fusobacterium | Klebsiella | Lactobacillaceae | Lactobacillus | Megasphaera | Prevotella | Pseudomonas | Ruminococcus gnavus | Streptococcus anginosus | Veillonella dispar | Veillonellaceae 7 (0.02) : Alistipes finegoldii | Bifidobacterium | Faecalibacterium prausnitzii | Leptotrichia | Odoribacter splanchnicus | Prevotella | Tenericutes
Rheumatoid Arthritis 0.0371 13 (0.06) : Actinomyces | Aggregatibacter actinomycetemcomitans | Campylobacter | Eggerthella | Fusobacterium | Klebsiella | Lactobacillaceae | Lactobacillus | Prevotella | Rothia | Staphylococcus aureus | Veillonella dispar | Veillonellaceae 5 (0.02) : Bifidobacterium | Leptotrichia | Prevotella | Roseburia | Sphingomonas
Human end-stage renal disease 0.0331 1 (0.00) : Fusobacterium 5 (0.06) : Bifidobacterium | Clostridium | Faecalibacterium prausnitzii | Peptostreptococcaceae | Roseburia
Primary biliary cholangitis 0.0319 7 (0.06) : Eubacterium | Fusobacterium | Klebsiella | Lactobacillales | Lactobacillus | Prevotella | Pseudomonas 0 (0.00)
Polycystic ovary syndrome 0.0307 5 (0.05) : Bacteriodes uniformis | Bacteroides ovatus | Bacteroides vulgatus | Lactobacillus | Prevotella 2 (0.01) : Prevotella | Tenericutes
Hypertension 0.0284 7 (0.04) : Actinomyces | Eggerthella | Fusobacterium | Klebsiella | Lactobacillus | Megasphaera | Prevotella 3 (0.01) : Bifidobacterium | Clostridium | Roseburia
Sjögren syndrome 0.0281 8 (0.03) : Bacteriodes uniformis | Bacteroides ovatus | Bacteroides thetaiotaomicron | Bacteroides vulgatus | Dialister | Lactobacillus | Prevotella | Staphylococcus aureus 6 (0.02) : Bifidobacterium | Clostridium | Leptotrichia | Peptostreptococcaceae | Prevotella | Roseburia
Celiac Disease 0.0278 7 (0.03) : Bacteroides vulgatus | Klebsiella | Lachnospiraceae | Lactobacillus | Megasphaera | Prevotella | Staphylococcus epidermidis 6 (0.03) : Bifidobacterium | Faecalibacterium prausnitzii | Leptotrichia | Peptostreptococcaceae | Prevotella | Rothia aeria
Hirschsprung's disease 0.0278 4 (0.06) : Actinomyces | Dialister | Prevotella | Pseudomonas 0 (0.00)
Obesity 0.0266 14 (0.04) : Aggregatibacter actinomycetemcomitans | Bacteroides vulgatus | Campylobacter | Corynebacterium | Dialister | Fusobacterium | Lactobacillus | Lactobacillus mucosae | Prevotella | Prevotella nigrescens | Pseudomonas | Selenomonas noxia | Staphylococcus aureus | Streptococcus anginosus 7 (0.01) : Bifidobacterium | Faecalibacterium prausnitzii | Haemophilus parainfluenzae | Leptotrichia | Odoribacter splanchnicus | Prevotella | Roseburia
Chronic Obstructive Pulmonary Disease 0.0264 11 (0.05) : Actinomyces | Campylobacter | Corynebacterium | Dialister | Eubacterium | Fusobacterium | Lactobacillus | Prevotella | Pseudomonas | Rothia | Veillonella dispar 3 (0.01) : Clostridium | Haemophilus parainfluenzae | Prevotella
Ankylosing spondylitis 0.0261 7 (0.04) : Actinomyces | Corynebacterium | Eggerthella | Lachnospiraceae | Megasphaera | Prevotella | Rothia 3 (0.01) : Alistipes shahii | Clostridium | Roseburia
Type 2 diabetes 0.0253 16 (0.05) : Actinomyces | Aggregatibacter actinomycetemcomitans | Corynebacterium | Deinococcus | Dialister | Eggerthella | Eubacterium | Fusobacterium | Klebsiella | Lachnospiraceae | Lactobacillus | Megasphaera | Prevotella | Pseudomonas | Ruminococcus gnavus | Streptococcus anginosus 4 (0.01) : Bifidobacterium | Faecalibacterium prausnitzii | Haemophilus parainfluenzae | Prevotella
Primary sclerosing cholangitis-IBD 0.0252 7 (0.03) : Corynebacterium | Fusobacterium | Lachnospiraceae | Lactobacillus | Megasphaera | Rothia | Veillonella dispar 3 (0.02) : Faecalibacterium prausnitzii | Prevotella | Roseburia
Macular degeneration 0.0250 4 (0.02) : Actinomyces | Campylobacter | Prevotella | Rothia 2 (0.03) : Leptotrichia | Prevotella
Atherosclerosis 0.0244 2 (0.00) : Klebsiella | Ruminococcus gnavus 4 (0.04) : Alistipes shahii | Faecalibacterium prausnitzii | Odoribacter splanchnicus | Roseburia
Fibromyalgia 0.0242 0 (0.00) 4 (0.05) : Bifidobacterium | Clostridium | Faecalibacterium prausnitzii | Haemophilus parainfluenzae
Crohn's disease 0.0240 16 (0.04) : Actinomyces | Bacteroides ovatus | Bacteroides vulgatus | Eggerthella | Fusobacterium | Klebsiella | Lachnospiraceae | Lactobacillales | Lactobacillus | Prevotella | Pseudomonas | Rothia | Ruminococcus gnavus | Staphylococcus aureus | Streptococcus anginosus | Veillonella dispar 6 (0.01) : Alistipes indistinctus | Bifidobacterium | Clostridium | Faecalibacterium prausnitzii | Prevotella | Roseburia
Hepatitis B 0.0240 5 (0.03) : Actinomyces | Eubacterium | Fusobacterium | Lactobacillus | Prevotella 4 (0.02) : Alistipes onderdonkii | Bifidobacterium | Faecalibacterium prausnitzii | Prevotella
Gastric carcinoma 0.0240 8 (0.04) : Corynebacterium | Fusobacterium | Klebsiella | Lachnospiraceae | Lactobacillus | Prevotella | Rhodococcus | Streptococcus anginosus 3 (0.01) : Prevotella | Roseburia | Sphingomonas
Osteoporosis 0.0237 3 (0.02) : Actinomyces | Eggerthella | Lactobacillus 1 (0.03) : Roseburia
Pancreatic head cancer 0.0234 6 (0.05) : Actinomyces | Campylobacter | Corynebacterium | Eubacterium | Fusobacterium | Rothia 0 (0.00)
Chronic kidney disease 0.0233 8 (0.02) : Actinomyces | Corynebacterium | Eggerthella | Flavonifractor | Lactobacillus | Pseudomonas | Rothia | Ruminococcus gnavus 6 (0.02) : Bifidobacterium | Clostridium | Faecalibacterium prausnitzii | Prevotella | Roseburia | Sphingomonas
Caries 0.0228 12 (0.03) : Actinomyces | Bacteroides thetaiotaomicron | Campylobacter | Lachnospiraceae | Lactobacillus | Megasphaera | Prevotella | Prevotella oris | Pseudomonas | Staphylococcus warneri | Veillonella dispar | Veillonellaceae 5 (0.01) : Haemophilus parainfluenzae | Leptotrichia | Prevotella | Rothia aeria | Streptococcus sanguinis
Spondyloarthritis 0.0218 3 (0.02) : Dialister | Lachnospiraceae | Ruminococcus gnavus 2 (0.02) : Faecalibacterium prausnitzii | Roseburia
Ulcerative Colitis 0.0213 10 (0.03) : Actinomyces | Bacteroides vulgatus | Bacteroidetes | Eggerthella | Lactobacillales | Lactobacillus | Prevotella | Rothia | Ruminococcus gnavus | Staphylococcus aureus 7 (0.02) : Alistipes shahii | Bifidobacterium | Faecalibacterium prausnitzii | Leptotrichia | Odoribacter splanchnicus | Prevotella | Roseburia
Autoimmune hepatitis 0.0203 3 (0.04) : Klebsiella | Lactobacillales | Lactobacillus 1 (0.00) : Bifidobacterium
Liver transplant 0.0202 0 (0.00) 2 (0.04) : Bifidobacterium | Faecalibacterium prausnitzii
Wilson's Disease 0.0202 0 (0.00) 2 (0.04) : Prevotella | Roseburia
Smoking 0.0199 9 (0.04) : Actinomyces | Corynebacterium | Fretibacterium fastidiosum | Fusobacterium | Lactobacillus | Prevotella | Prevotella oris | Rothia | Veillonella dispar 2 (0.00) : Leptotrichia | Prevotella
Cystic fibrosis 0.0198 8 (0.03) : Lachnospiraceae | Lactobacillales | Megasphaera | Pseudomonas | Ruminococcus gnavus | Staphylococcus aureus | Staphylococcus epidermidis | Veillonella dispar 5 (0.01) : Bifidobacterium | Faecalibacterium prausnitzii | Leptotrichia | Prevotella | Roseburia
Spinal cord injury 0.0198 2 (0.01) : Corynebacterium | Veillonellaceae 3 (0.03) : Prevotella | Pseudobutyrivibrio | Roseburia
Short Bowel Syndrome 0.0193 5 (0.02) : Fusobacterium | Klebsiella | Lactobacillus | Megasphaera | Prevotella 4 (0.01) : Peptostreptococcaceae | Prevotella | Pseudobutyrivibrio | Roseburia
Cirrhosis with pneumonia 0.0188 3 (0.04) : Actinomyces | Eubacterium | Lachnospiraceae 0 (0.00)
Pancreatic Cancer 0.0187 7 (0.04) : Aggregatibacter actinomycetemcomitans | Campylobacter | Klebsiella | Lachnospiraceae | Lactobacillus | Megasphaera | Prevotella 1 (0.00) : Bifidobacterium
Alcoholism 0.0187 9 (0.03) : Actinomyces | Corynebacterium | Dialister | Eubacterium | Klebsiella | Lachnospiraceae | Lactobacillus | Prevotella | Rothia 2 (0.00) : Bifidobacterium | Prevotella
Alzheimer's disease 0.0175 6 (0.03) : Bacteroides vulgatus | Bacteroidetes | Lactobacillaceae | Lactobacillus | Pseudomonas | Veillonellaceae 3 (0.01) : Bifidobacterium | Clostridium | Halomonas
Autism 0.0173 11 (0.02) : Bacteroides vulgatus | Blautia faecis | Corynebacterium | Lachnospiraceae | Lactobacillus | Megasphaera | Prevotella oulorum | Pseudomonas | Rothia | Ruminococcus gnavus | Veillonellaceae 7 (0.01) : Alistipes onderdonkii | Bifidobacterium | Faecalibacterium prausnitzii | Haemophilus parainfluenzae | Peptostreptococcaceae | Prevotella | Roseburia
Coronary artery disease 0.0167 8 (0.03) : Bacteroidetes | Klebsiella | Lactobacillales | Lactobacillus | Megasphaera | Prevotella | Pseudomonas | Ruminococcus gnavus 1 (0.00) : Roseburia
Viral respiratory tract infection 0.0166 1 (0.00) : Staphylococcus aureus 1 (0.03) : Prevotella
Type 1 diabetes 0.0165 5 (0.01) : Bacteriodes uniformis | Bacteroides ovatus | Bacteroides thetaiotaomicron | Bacteroides vulgatus | Prevotella 5 (0.02) : Bifidobacterium | Faecalibacterium prausnitzii | Peptostreptococcaceae | Prevotella | Roseburia
Psoriasis 0.0165 11 (0.03) : Actinomyces | Bacteroides vulgatus | Dialister | Fretibacterium fastidiosum | Lachnospiraceae | Lactobacillales | Megasphaera | Moraxellaceae | Prevotella | Pseudomonas | Ruminococcus gnavus 1 (0.00) : Xanthomonadaceae
Lung cancer 0.0164 3 (0.01) : Lachnospiraceae | Prevotella | Ruminococcus gnavus 4 (0.02) : Bifidobacterium | Clostridium | Faecalibacterium prausnitzii | Sphingomonas
Cardiac valve calcification 0.0156 3 (0.03) : Fusobacterium | Lactobacillus | Veillonella dispar 0 (0.00)
Inflamatory bowel disease 0.0154 5 (0.02) : Bacteroides vulgatus | Moraxellaceae | Prevotella | Ruminococcus gnavus | Streptococcus anginosus 3 (0.01) : Bifidobacterium | Faecalibacterium prausnitzii | Prevotella
Urogenital Schistosomiasis 0.0153 5 (0.03) : Dialister | Fusobacterium | Lactobacillus | Megasphaera | Prevotella 0 (0.00)
Infective colitis 0.0152 0 (0.00) 2 (0.03) : Bifidobacterium | Faecalibacterium prausnitzii
Infant colic 0.0152 0 (0.00) 1 (0.03) : Bifidobacterium
Laryngotracheal stenosis 0.0152 0 (0.00) 1 (0.03) : Prevotella
Diabetic nephropathy 0.0152 0 (0.00) 1 (0.03) : Prevotella
Autoimmune Thyroid Disorders 0.0152 0 (0.00) 2 (0.03) : Bifidobacterium | Faecalibacterium prausnitzii
Major depressive disorder 0.0151 4 (0.02) : Actinomyces | Bacteroidetes | Eggerthella | Eubacterium 3 (0.01) : Bifidobacterium | Clostridium | Prevotella
Oral cancer 0.0150 7 (0.03) : Actinomyces | Fusobacterium | Lactobacillus | Prevotella | Rothia | Staphylococcus aureus | Streptococcus anginosus 2 (0.00) : Leptotrichia | Sphingomonas
Attention Deficit Hyperactivity Disorder 0.0143 4 (0.03) : Bacteriodes uniformis | Bacteroides ovatus | Fusobacterium | Moraxellaceae 1 (0.00) : Faecalibacterium prausnitzii
Parkinson's Disease 0.0142 9 (0.01) : Dialister | Klebsiella | Lachnospiraceae | Lactobacillaceae | Lactobacillus | Lactobacillus mucosae | Moraxellaceae | Prevotella | Rhodococcus 7 (0.02) : Clostridium | Faecalibacterium prausnitzii | Halomonas | Leptotrichia | Micrococcaceae | Prevotella | Roseburia
Denture Stomatitis 0.0142 1 (0.02) : Fusobacterium 1 (0.01) : Streptococcus sanguinis
Maturity-onset diabetes of the young 2 0.0142 1 (0.02) : Prevotella 1 (0.01) : Roseburia
Cervicitis 0.0139 2 (0.03) : Eggerthella | Prevotella 0 (0.00)
Seminal hyperviscosity 0.0139 2 (0.03) : Klebsiella | Pseudomonas 0 (0.00)
Oligoasthenoteratozoospermia 0.0139 2 (0.03) : Klebsiella | Pseudomonas 0 (0.00)
Influenza A 0.0139 4 (0.03) : Actinomyces | Eubacterium | Lactobacillus | Pseudomonas 0 (0.00)
Kaposi's sarcoma 0.0139 2 (0.03) : Corynebacterium | Dialister 0 (0.00)
Anovulation 0.0138 2 (0.02) : Dialister | Prevotella 2 (0.01) : Leptotrichia | Roseburia
Heart failure 0.0137 3 (0.02) : Campylobacter | Fusobacterium | Lactobacillus 2 (0.01) : Clostridium | Faecalibacterium prausnitzii
Behcet's Disease 0.0135 4 (0.02) : Eggerthella | Fusobacterium | Lactobacillus mucosae | Rothia 4 (0.01) : Clostridium | Leptotrichia | Prevotella | Roseburia
Edentulism 0.0135 6 (0.02) : Dialister | Eubacterium | Megasphaera | Prevotella nigrescens | Streptococcus anginosus | Veillonella dispar 2 (0.00) : Peptostreptococcaceae | Rothia aeria
Aphthous ulcer 0.0133 3 (0.01) : Lactobacillus | Prevotella | Streptococcus anginosus 2 (0.01) : Leptotrichia | Sphingomonas
Acute lymphoblastic leukemia 0.0132 1 (0.01) : Bacteriodes uniformis 3 (0.02) : Bifidobacterium | Prevotella | Pseudobutyrivibrio
Hepatocellular cancer 0.0131 8 (0.02) : Actinomyces | Campylobacter | Eggerthella | Eubacterium | Fusobacterium | Lachnospiraceae | Prevotella | Pseudomonas 1 (0.00) : Bifidobacterium
Idiopathic Pulmonary Fibrosis 0.0128 4 (0.03) : Bacteroidetes | Campylobacter | Prevotella | Rothia 0 (0.00)
Gestational diabetes 0.0127 5 (0.02) : Actinomyces | Klebsiella | Lachnospiraceae | Prevotella | Rothia 2 (0.00) : Prevotella | Xanthomonadaceae
Tongue cancer 0.0126 3 (0.02) : Actinomyces | Corynebacterium | Rothia 1 (0.00) : Prevotella
Atopic Dermatitis 0.0125 5 (0.02) : Corynebacterium | Lactobacillus | Rhodococcus | Staphylococcus aureus | Staphylococcus epidermidis 3 (0.01) : Bifidobacterium | Clostridium | Leptotrichia
Aggressive periodontitis 0.0125 3 (0.00) : Eubacterium | Prevotella | Treponema maltophilum 6 (0.02) : Bifidobacterium | Haemophilus parainfluenzae | Leptotrichia | Prevotella | Streptococcus sanguinis | Xanthomonadaceae
Vaginal Chlamydiosis 0.0125 6 (0.02) : Corynebacterium | Dialister | Lactobacillus | Megasphaera | Prevotella | Pseudomonas 0 (0.00)
Non-alcoholic fatty liver disease 0.0124 3 (0.01) : Lachnospiraceae | Lactobacillus | Lactobacillus mucosae 6 (0.02) : Clostridium | Faecalibacterium prausnitzii | Peptostreptococcaceae | Prevotella | Pseudobutyrivibrio | Roseburia
Bacterial vaginosis 0.0121 8 (0.02) : Actinomyces | Dialister | Eggerthella | Lachnospiraceae | Megasphaera | Prevotella | Prevotella nigrescens | Streptococcus anginosus 0 (0.00)
Sickle cell disease 0.0121 0 (0.00) 2 (0.02) : Prevotella | Pseudobutyrivibrio
Biliary atresia 0.0121 2 (0.02) : Klebsiella | Lactobacillus 1 (0.00) : Bifidobacterium
Psychogenic erectile dysfunction 0.0121 0 (0.00) 2 (0.02) : Prevotella | Roseburia
Invasive pneumococcal disease 0.0119 4 (0.02) : Actinomyces | Megasphaera | Prevotella | Rothia 0 (0.00)
H7N9 0.0117 3 (0.02) : Fusobacterium | Megasphaera | Pseudomonas 0 (0.00)
Colorectal cancer 0.0116 9 (0.01) : Actinomyces | Campylobacter | Eubacterium | Fusobacterium | Klebsiella | Lactobacillus | Prevotella | Pseudomonas | Streptococcus anginosus 6 (0.01) : Bifidobacterium | Faecalibacterium prausnitzii | Leptotrichia | Prevotella | Roseburia | Sphingomonas
HIV infection 0.0116 7 (0.01) : Campylobacter | Corynebacterium | Fusobacterium | Klebsiella | Lactobacillus | Prevotella | Selenomonas noxia 5 (0.01) : Bifidobacterium | Clostridium | Peptostreptococcaceae | Prevotella | Roseburia
Asthma 0.0115 7 (0.02) : Actinomyces | Eubacterium | Flavonifractor | Klebsiella | Lactobacillus | Pseudomonas | Rothia 3 (0.01) : Bifidobacterium | Leptotrichia | Prevotella
Schizophrenia 0.0114 9 (0.02) : Actinomyces | Eggerthella | Flavonifractor | Klebsiella | Lactobacillus | Megasphaera | Ruminococcus gnavus | Veillonella dispar | Veillonellaceae 1 (0.00) : Clostridium
Acne 0.0113 5 (0.02) : Corynebacterium | Klebsiella | Rhodococcus | Staphylococcus epidermidis | Staphylococcus hominis 1 (0.00) : Bifidobacterium
Periodontal disease 0.0111 4 (0.01) : Fretibacterium fastidiosum | Prevotella | Treponema maltophilum | Veillonellaceae 3 (0.01) : Haemophilus parainfluenzae | Rothia aeria | Sphingomonas
Migraine 0.0109 3 (0.01) : Lachnospiraceae | Pseudomonas | Ruminococcus gnavus 1 (0.01) : Faecalibacterium prausnitzii
Non alcoholic steatohepatitis 0.0106 3 (0.01) : Lactobacillus | Lactobacillus mucosae | Prevotella 2 (0.01) : Bifidobacterium | Roseburia
Pneumonia 0.0105 2 (0.02) : Prevotella | Rothia 1 (0.00) : Leptotrichia
Chronic Rhinosinusitis 0.0104 4 (0.02) : Campylobacter | Fusobacterium | Pseudomonas | Staphylococcus aureus 0 (0.00)
T2D with hypertension and hyperlipidemia 0.0104 1 (0.02) : Prevotella 0 (0.00)
Bullous pemphigoid 0.0104 2 (0.02) : Corynebacterium | Staphylococcus epidermidis 0 (0.00)
Shiga Toxin-producing E. coli infection 0.0104 1 (0.02) : Lactobacillales 0 (0.00)
Giardia intestinalis infection 0.0104 1 (0.02) : Prevotella 0 (0.00)
Chronic ocular graft-versus-host disease 0.0104 2 (0.02) : Corynebacterium | Staphylococcus epidermidis 0 (0.00)
Intrahepatic Cholangiocarcinoma 0.0104 2 (0.02) : Actinomyces | Lactobacillus 0 (0.00)
Systemic sclerosis 0.0103 3 (0.02) : Fusobacterium | Lactobacillus | Prevotella 1 (0.01) : Clostridium
Budd-Chiari syndrome 0.0103 1 (0.01) : Megasphaera 1 (0.01) : Peptostreptococcaceae
Irritable bowel syndrome 0.0102 8 (0.02) : Actinomyces | Dialister | Klebsiella | Lactobacillales | Lactobacillus | Prevotella | Ruminococcus gnavus | Veillonellaceae 2 (0.00) : Bifidobacterium | Roseburia
Idiopathic REM Sleep Behavior Disorder 0.0102 2 (0.02) : Eggerthella | Flavonifractor 1 (0.00) : Prevotella
Atopic wheeze 0.0102 1 (0.01) : Ruminococcus gnavus 1 (0.02) : Bifidobacterium
Breast cancer 0.0102 4 (0.01) : Actinomyces | Bacteroidetes | Corynebacterium | Fusobacterium 2 (0.01) : Prevotella | Sphingomonadaceae
Clostridium difficile infection 0.0101 4 (0.01) : Corynebacterium | Eggerthella | Klebsiella | Lactobacillus 3 (0.01) : Bifidobacterium | Faecalibacterium prausnitzii | Prevotella
Juvenile idiopathic arthritis 0.0100 3 (0.02) : Bacteroidetes | Klebsiella | Veillonellaceae 1 (0.00) : Peptostreptococcaceae
Cholestasis 0.0100 1 (0.00) : Megasphaera 3 (0.02) : Bifidobacterium | Faecalibacterium prausnitzii | Roseburia
Generalized anxiety disorder 0.0100 3 (0.02) : Bacteroidetes | Fusobacterium | Ruminococcus gnavus 1 (0.00) : Prevotella
Pancreatitis 0.0097 1 (0.00) : Prevotella 3 (0.02) : Bifidobacterium | Faecalibacterium prausnitzii | Prevotella
Silicosis 0.0097 2 (0.02) : Dialister | Lachnospiraceae 1 (0.00) : Bifidobacterium
Glycogen storage disease 0.0096 2 (0.02) : Lactobacillus | Ruminococcus gnavus 1 (0.00) : Roseburia
Transient Ischemic Attack 0.0092 3 (0.01) : Eubacterium | Lactobacillus | Megasphaera 1 (0.01) : Prevotella
Reactive arthritis 0.0090 1 (0.01) : Pseudomonas 1 (0.01) : Roseburia
Fatigue 0.0090 1 (0.01) : Ruminococcus gnavus 1 (0.01) : Faecalibacterium prausnitzii
Obstructive sleep apnea-hypopnea syndrome 0.0089 3 (0.01) : Fusobacterium | Prevotella | Pseudomonas 2 (0.00) : Acidobacteria | Bifidobacterium
Anorexia nervosa 0.0087 0 (0.00) 2 (0.02) : Clostridium | Roseburia
Dry eye syndrom 0.0085 3 (0.02) : Lactobacillaceae | Megasphaera | Prevotella 0 (0.00)
Extrinsic black dental staining 0.0085 3 (0.02) : Actinomyces | Corynebacterium | Fusobacterium 0 (0.00)
Eosinophilic esophagitis 0.0083 2 (0.02) : Campylobacter | Corynebacterium 0 (0.00)
Gestational diabetes + hyperlipidemia 0.0083 2 (0.02) : Actinomyces | Prevotella 0 (0.00)
Iron-deficiency anaemia 0.0083 2 (0.02) : Lactobacillus | Pseudomonas 0 (0.00)
Thyroid carcinoma 0.0080 3 (0.01) : Klebsiella | Lactobacillus | Prevotella 2 (0.01) : Prevotella | Roseburia
Stevens-Johnson syndrome 0.0078 4 (0.01) : Fusobacterium | Lactobacillus | Prevotella | Pseudomonas 1 (0.00) : Clostridium
Multiple Sclerosis 0.0076 3 (0.00) : Actinomyces | Eggerthella | Lactobacillus 4 (0.01) : Clostridium | Faecalibacterium prausnitzii | Prevotella | Roseburia
Gout 0.0076 0 (0.00) 1 (0.02) : Faecalibacterium prausnitzii
Cavernous angioma 0.0076 0 (0.00) 1 (0.02) : Faecalibacterium prausnitzii
Hyperthyroidism 0.0076 0 (0.00) 1 (0.02) : Bifidobacterium
Prediabetes 0.0076 0 (0.00) 1 (0.02) : Clostridium
Allergic asthma 0.0076 0 (0.00) 1 (0.02) : Faecalibacterium prausnitzii
Frailty 0.0076 0 (0.00) 1 (0.02) : Faecalibacterium prausnitzii
Diarrhea 0.0076 0 (0.00) 1 (0.02) : Bifidobacterium
Posttreatment Lyme disease syndrome 0.0076 0 (0.00) 1 (0.02) : Roseburia
Neuromyelitis optica 0.0074 2 (0.01) : Corynebacterium | Flavonifractor 2 (0.01) : Peptostreptococcaceae | Roseburia
Common Variable Immunodeficieny 0.0069 2 (0.01) : Campylobacter | Eggerthella 0 (0.00)
Bleeding gum 0.0069 2 (0.01) : Fusobacterium | Prevotella 0 (0.00)
Hidradenitis suppurativa 0.0068 1 (0.00) : Corynebacterium 1 (0.01) : Cutibacterium
Preeclamsia 0.0067 4 (0.01) : Bacteroidetes | Dialister | Fusobacterium | Prevotella 0 (0.00)
Chagas' disease 0.0067 2 (0.01) : Fusobacterium | Lactobacillus 1 (0.01) : Leptotrichia
Hashimoto's thyroiditis 0.0067 0 (0.00) 2 (0.01) : Bifidobacterium | Prevotella
Chronic Laryngitis 0.0066 1 (0.01) : Pseudomonas 1 (0.00) : Prevotella
Hepatic encephalopathy 0.0066 3 (0.01) : Lactobacillaceae | Lactobacillales | Megasphaera 1 (0.00) : Roseburia
Keratitis 0.0065 0 (0.00) 3 (0.01) : Clostridium | Faecalibacterium prausnitzii | Roseburia
Metabolic syndrome 0.0061 0 (0.00) 2 (0.01) : Bifidobacterium | Faecalibacterium prausnitzii
Periodontal abscess 0.0061 0 (0.00) 2 (0.01) : Leptotrichia | Prevotella
Depression 0.0060 2 (0.01) : Bacilli | Lactobacillus 0 (0.00)
Oral lichen planus 0.0060 2 (0.01) : Fusobacterium | Prevotella 2 (0.01) : Haemophilus parainfluenzae | Streptococcus sanguinis
Human papilloma virus infection 0.0060 2 (0.01) : Dialister | Eggerthella 0 (0.00)
Granulomatosis with polyangiitis 0.0060 2 (0.01) : Corynebacterium | Staphylococcus aureus 0 (0.00)
Invasive colorectal cancer 0.0060 2 (0.01) : Corynebacterium | Fusobacterium 0 (0.00)
Pressure ulcers 0.0059 3 (0.01) : Ruminococcus gnavus | Staphylococcus aureus | Staphylococcus epidermidis 0 (0.00)
Acquired Immunodeficiency Syndrome 0.0058 1 (0.00) : Lactobacillus 2 (0.01) : Prevotella | Roseburia
Covid-19 0.0058 2 (0.00) : Actinomyces | Rothia 2 (0.01) : Faecalibacterium prausnitzii | Roseburia
Pulmonary tubercolosis 0.0057 2 (0.00) : Lactobacillus | Veillonella dispar 3 (0.01) : Haemophilus parainfluenzae | Prevotella | Roseburia
Urinary stone disease 0.0052 1 (0.01) : Lactobacillales 0 (0.00)
Conjunctival scarring 0.0052 1 (0.01) : Corynebacterium 0 (0.00)
Colon adenomas 0.0052 3 (0.01) : Bacteroidetes | Fusobacterium | Pseudomonas 0 (0.00)
Exacerbations of idiopathic pulmonary fibrosis 0.0052 1 (0.01) : Campylobacter 0 (0.00)
Hirschsprung-associated enterocolitis 0.0052 1 (0.01) : Bacteroidetes 0 (0.00)
Urolithiasis 0.0052 1 (0.01) : Lachnospiraceae 0 (0.00)
Chronic pancreatitis 0.0052 1 (0.01) : Dialister 1 (0.00) : Peptostreptococcaceae
Traumatic Brain Injury 0.0052 1 (0.01) : Bacteroides thetaiotaomicron 0 (0.00)
Halitosis 0.0051 3 (0.01) : Campylobacter | Dialister | Prevotella 1 (0.00) : Haemophilus parainfluenzae
Gingivitis 0.0051 0 (0.00) 1 (0.01) : Prevotella
Endometriosis 0.0051 3 (0.01) : Corynebacterium | Prevotella | Pseudomonas 1 (0.00) : Prevotella
Sicca syndrome 0.0051 3 (0.01) : Actinomyces | Megasphaera | Prevotella 1 (0.00) : Sphingomonas
Chronic mucocutaneous candidiasis 0.0051 0 (0.00) 1 (0.01) : Prevotella
Hyper IgE syndrome 0.0051 0 (0.00) 1 (0.01) : Prevotella
Microscopic colitis 0.0049 1 (0.00) : Lachnospiraceae 2 (0.01) : Clostridium | Prevotella
Postmenopausal 0.0048 1 (0.00) : Prevotella 1 (0.01) : Roseburia
Amyotrophic lateral sclerosis 0.0047 2 (0.00) : Bacteroides vulgatus | Lachnospiraceae 1 (0.01) : Clostridium
Primary biliary cirrhosis 0.0047 1 (0.00) : Klebsiella 1 (0.01) : Acidobacteria
Primary liver cancer 0.0046 2 (0.01) : Bacteriodes uniformis | Ruminococcus gnavus 0 (0.00)
Diaper dermatitis 0.0046 2 (0.01) : Ruminococcus gnavus | Staphylococcus aureus 0 (0.00)
Otitis Media 0.0045 3 (0.01) : Fusobacterium | Klebsiella | Prevotella 0 (0.00)
Autoimmune polyendocrine syndrome type 1 0.0045 0 (0.00) 3 (0.01) : Haemophilus parainfluenzae | Leptotrichia | Peptostreptococcaceae
Myasthenia gravis 0.0043 0 (0.00) 2 (0.01) : Clostridium | Faecalibacterium prausnitzii
Graves' disease 0.0043 1 (0.01) : Prevotella 1 (0.00) : Bifidobacterium
Hepatitis B associated liver failure 0.0043 1 (0.00) : Moraxellaceae 1 (0.01) : Xanthomonadaceae
Preterm birth 0.0042 2 (0.01) : Prevotella | Rothia 0 (0.00)
Primary sclerosing cholangitis 0.0042 3 (0.01) : Fusobacterium | Lactobacillus | Veillonella dispar 1 (0.00) : Faecalibacterium prausnitzii
Alcoholic Hepatitis 0.0042 3 (0.01) : Actinomyces | Lactobacillus | Rothia 1 (0.00) : Prevotella
Chronic alcoholic pancreatitis 0.0042 1 (0.00) : Pseudomonas 2 (0.01) : Prevotella | Roseburia
Laryngeal carcinoma 0.0041 3 (0.01) : Dialister | Fusobacterium | Prevotella 0 (0.00)
Idiopathic focal epilepsy 0.0040 1 (0.00) : Campylobacter 1 (0.00) : Bifidobacterium
Bladder cancer 0.0038 1 (0.00) : Fusobacterium 2 (0.01) : Bifidobacterium | Prevotella
Barrett's oesophagus 0.0038 2 (0.01) : Campylobacter | Fusobacterium 0 (0.00)
Aphthous stomatitis 0.0038 0 (0.00) 1 (0.01) : Clostridium
Severe fever with thrombocytopenia syndrome 0.0038 1 (0.00) : Lactobacillus 1 (0.01) : Prevotella
Primary immune thrombocytopenia 0.0038 0 (0.00) 1 (0.01) : Peptostreptococcaceae
Kidney stone with hypertension 0.0038 2 (0.01) : Lactobacillus | Rhodococcus 0 (0.00)
Fibrosis 0.0038 0 (0.00) 1 (0.01) : Faecalibacterium prausnitzii
Allergy 0.0037 1 (0.00) : Ruminococcus gnavus 1 (0.00) : Prevotella
Head/Neck cancer 0.0036 1 (0.00) : Streptococcus anginosus 1 (0.00) : Haemophilus parainfluenzae
Trachoma 0.0035 1 (0.01) : Corynebacterium 0 (0.00)
Cervical intraneoplasia 0.0035 1 (0.01) : Lactobacillus 0 (0.00)
Recurrent miscarriage 0.0035 1 (0.01) : Prevotella 0 (0.00)
Radiation enteritis 0.0035 1 (0.01) : Prevotella 0 (0.00)
Genitourinary lichen sclerosus 0.0035 1 (0.01) : Lactobacillus 0 (0.00)
Recurrent tonsillitis 0.0034 0 (0.00) 2 (0.01) : Haemophilus parainfluenzae | Streptococcus sanguinis
Ischemic stroke 0.0034 1 (0.00) : Lactobacillaceae 1 (0.00) : Roseburia
Oropharyngeal cancer 0.0034 1 (0.01) : Streptococcus anginosus 1 (0.00) : Rothia aeria
Aerobic vaginitis 0.0032 4 (0.01) : Dialister | Lactobacillus mucosae | Streptococcus anginosus | Veillonella dispar 0 (0.00)
Hand, foot and mouth disease 0.0030 0 (0.00) 1 (0.01) : Roseburia
Colon polyps 0.0030 2 (0.01) : Bacteroides vulgatus | Ruminococcus gnavus 0 (0.00)
Vogt-Koyagani-Harada disease 0.0030 0 (0.00) 1 (0.01) : Clostridium
Chronic urticaria 0.0030 0 (0.00) 1 (0.01) : Bifidobacterium
Hemodialysis with Normal Weight Obesity 0.0030 0 (0.00) 1 (0.01) : Faecalibacterium prausnitzii
Bipolar disorder 0.0029 1 (0.00) : Flavonifractor 1 (0.00) : Roseburia
Infantile eczema 0.0028 1 (0.00) : Flavonifractor 2 (0.00) : Bifidobacterium | Prevotella
Hepatitis C 0.0028 2 (0.01) : Lactobacillus | Prevotella 0 (0.00)
Kidney stone 0.0027 2 (0.00) : Bacteroides ovatus | Lachnospiraceae 1 (0.00) : Prevotella
Pulmonary arterial hypertension 0.0027 1 (0.00) : Ruminococcus gnavus 1 (0.00) : Alistipes finegoldii
Pouchitis 0.0026 2 (0.01) : Eubacterium | Prevotella 0 (0.00)
Blepharitis 0.0026 1 (0.01) : Corynebacterium 0 (0.00)
Bronchiectasis 0.0026 1 (0.01) : Pseudomonas 0 (0.00)
Pediculosis 0.0026 1 (0.01) : Staphylococcus epidermidis 0 (0.00)
Collagenous colitis 0.0026 1 (0.01) : Lachnospiraceae 0 (0.00)
Anti-N-methyl-D-aspartate receptor encephalitis 0.0026 1 (0.01) : Fusobacterium 0 (0.00)
Rectal Carcinoma 0.0025 0 (0.00) 1 (0.01) : Bifidobacterium
Chronic prostatitis - Chronic pelvic pain syndrome 0.0025 0 (0.00) 1 (0.01) : Prevotella
Alcoholic cirrhosis 0.0025 0 (0.00) 1 (0.01) : Prevotella
Mucosa-associated lymphoid tissue lymphoma 0.0024 1 (0.00) : Rothia 1 (0.00) : Clostridium
Dandruff 0.0023 2 (0.00) : Pseudomonas | Staphylococcus epidermidis 0 (0.00)
Refractory celiac disease 0.0022 0 (0.00) 1 (0.00) : Haemophilus parainfluenzae
Arsenic exposure 0.0022 0 (0.00) 1 (0.00) : Bifidobacterium
Opisthorchis felineus infection 0.0021 2 (0.00) : Bacteriodes uniformis | Veillonella dispar 0 (0.00)
Liver fibrosis 0.0021 1 (0.00) : Prevotella 0 (0.00)
Tetratricopeptide repeat domain 7A deficiency 0.0021 1 (0.00) : Campylobacter 0 (0.00)
Spleen deficiency syndrome 0.0021 1 (0.00) : Bacteriodes uniformis 0 (0.00)
Chronic stress 0.0021 1 (0.00) : Rhodococcus 0 (0.00)
Protracted bacterial bronchitis 0.0020 2 (0.00) : Prevotella | Pseudomonas 0 (0.00)
Posttraumatic stress syndrome 0.0019 0 (0.00) 1 (0.00) : Roseburia
Coronary Heart Disease 0.0017 0 (0.00) 1 (0.00) : Prevotella
Constipation 0.0017 0 (0.00) 1 (0.00) : Prevotella
Alopecia areata 0.0017 1 (0.00) : Bacteroidetes 0 (0.00)
Down syndrome 0.0017 1 (0.00) : Selenomonas noxia 0 (0.00)
Functional dyspepsia 0.0015 1 (0.00) : Bacteriodes uniformis 0 (0.00)
Oral leukoplakia 0.0015 1 (0.00) : Campylobacter 0 (0.00)
Alopecia universalis 0.0015 1 (0.00) : Lachnospiraceae 0 (0.00)
Atrophic gastritis 0.0014 0 (0.00) 1 (0.00) : Roseburia
Graves' orbitopathy 0.0014 0 (0.00) 1 (0.00) : Alistipes shahii
COPD Exacerbation 0.0013 0 (0.00) 1 (0.00) : Prevotella
Overactive bladder 0.0012 0 (0.00) 1 (0.00) : Prevotella
Uveitits 0.0011 1 (0.00) : Prevotella 1 (0.00) : Roseburia

[Overlap Factors (Causality ?)]

FactorOverlapCommon increased OrganismCommon decreased Organism
Exposure to Glyphosate 0.0156 3 (0.03) : Actinomyces | Fusobacterium | Prevotella 0 (0.00)
Low FODMAP diet 0.0152 0 (0.00) 1 (0.03) : Bifidobacterium
Protein powder consumption 0.0121 1 (0.02) : Bacteroidetes 1 (0.00) : Roseburia
High Socio-economic status 0.0104 2 (0.02) : Eubacterium | Lachnospiraceae 0 (0.00)
Grape powder consumption 0.0102 1 (0.01) : Flavonifractor 1 (0.02) : Bifidobacterium
Aging 0.0076 0 (0.00) 1 (0.02) : Bifidobacterium
Maternal Antibiotic Exposure 0.0076 0 (0.00) 1 (0.02) : Bifidobacterium
Oral administration of Metformin 0.0068 2 (0.01) : Bacteroidetes | Megasphaera 1 (0.00) : Roseburia
Probiotic (Bifidobacter and Lactobacilus) 0.0052 1 (0.01) : Lactobacillaceae 0 (0.00)
Eating appel 0.0052 1 (0.01) : Bacteroidetes 0 (0.00)
Curcumin Supplementation 0.0052 1 (0.01) : Lactobacillaceae 0 (0.00)
Antibiotic Therapy 0.0035 1 (0.01) : Lactobacillales 0 (0.00)
Mediterranean diet 0.0035 1 (0.01) : Lachnospiraceae 0 (0.00)
Cannabis smoking 0.0035 1 (0.01) : Actinomyces 0 (0.00)
Consumption of Coffee 0.0012 1 (0.00) : Dialister 0 (0.00)

[Reverse Overlap Factors (Curability ?)]

FactorOverlapIncrease decreased Org/DisDecrease increased Org/Dis
High salt diet 0.0204 1 (0.01) : Bifidobacterium 1 (0.03) : Lactobacillus
Mediterranean diet 0.0189 2 (0.03) : Faecalibacterium prausnitzii | Roseburia 1 (0.01) : Ruminococcus gnavus
Exposure to Glyphosate 0.0169 1 (0.00) : Prevotella 2 (0.03) : Lactobacillus | Rothia
Sugar intake 0.0152 0 (0.00) 1 (0.03) : Lactobacillus
Protein powder consumption 0.0152 0 (0.00) 3 (0.03) : Bacilli | Lachnospiraceae | Lactobacillales
Heat Stress 0.0128 1 (0.01) : Clostridium 1 (0.02) : Lactobacillus
Maternal Antibiotic Exposure 0.0076 0 (0.00) 1 (0.02) : Bacteroidetes
Grape powder consumption 0.0076 0 (0.00) 1 (0.02) : Dialister
Consumption of Coffee 0.0046 2 (0.01) : Bifidobacterium | Roseburia 0 (0.00)
Antibiotic Therapy 0.0038 0 (0.00) 1 (0.01) : Lactobacillales
Oral administration of Metformin 0.0022 0 (0.00) 1 (0.00) : Lactobacillus
High-fat diet 0.0019 0 (0.00) 1 (0.00) : Bacteroidetes

Common References