MetaBiom
Microbiome & Chronic Diseases

Evidence Based Medicine

Psoriasis {40000128}

Record Keys


Definition:
Psoriasis
Class:[  ]

Details


Other Terms:[  ]
Authoring date:
2020-09-06

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Meta Information


ICD:[  ]
Category:
Dermatology
MedDra ID:
10037153
MedDra Level:
4

Notes


- Among bacterial species with higher abundance in the psoriasis gut microbiome, Bacteroides vulgatus and Parasutterella excrementihominis have been associated with other immune-mediated diseases.
- Increased intestinal colonization of Bacteroides vulgatus and elevated Bacteroides vulgatus reactive serum antibodies have been reported in ulcerative colitis patients.
- Moreover, colonization of Bacteroides vulgatus is sufficient to promote colitis in several animal models, which further supports the active role of Bacteroides vulgatus in development of colitis.
- The abundance of Akkermansia muciniphila was significantly reduced in patients with psoriasis .
- A. muciniphila is believed to have an important function in the pathogenesis of IBD and obesity; therefore, A. muciniphila, which is an indicator of health status, may be a key node for psoriasis as well as IBD and obesity. (1)

Shared Notes


  • [1.20
    - The psoriatic subject showed a decrease in Firmicutes abundance and an increase in Proteobacteria abundance.
    - An increase in Streptococcaceae, Rhodobacteraceae, Campylobacteraceae and Moraxellaceae has been observed in psoriatic subject.
  • [1.21
    - Antibiotic treatment resulted in a substantial increase in the order Lactobacillales.
    - Antibiotic treatment resulted in a significant decrease in Coriobacteriales and Clostridiales.

Common References