MetaBiom
Microbiome & Chronic Diseases

Evidence Based Medicine

Gout {40000127}

Record Keys


Definition:
Gout
Class:[  ]

Details


Other Terms:
Podagra arthritis uric acid Hyperuricemia
Authoring date:
2020-09-06

Links


Meta Information


ICD:[  ]
Category:
Rheumatologic
MedDra ID:[  ]
MedDra Level:[  ]

Notes


[  ]

Shared Notes


  • [1.1
    - In gout, Bacteroides caccae and Bacteroides xylanisolvens are enriched.
    - Faecalibacterium prausnitzii and Bifidobacterium pseudocatenulatum depleted.
    - The established reference microbial gene catalogue for gout revealed disorder in purine degradation and butyric acid biosynthesis in gout patients.
    - Intestinal microbiota of gout are more similar to those of type-2 diabetes than to liver cirrhosis, whereas depletion of Faecalibacterium prausnitzii and reduced butyrate biosynthesis are shared in each of the metabolic syndromes.
    - Bacteroides caccae is one biomarker of IBD. OmpW protein produced by B. caccae is a target of the IBD-associated immune response, thus the enriched intestinal B. caccae in gout patients could potentially induce serious inflammatory response.
    - Faecalibacterium prausnitzii has anti-inflammatory properties and contribute to gut health through butyrate production. for gout patients, potentially explaining the decline in butyric acid biosynthesis in gout patients.

Common References