Sjögren syndrome {40000122}
Definition: | Sjögren syndrome |
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Class: | [ ] |
Other Terms: | SJS, SS, PSS |
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Authoring date: | 2020-09-06 |
ICD: | [ ] |
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Category: | Rheumatologic |
MedDra ID: | [ ] |
MedDra Level: | [ ] |
Notes
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Shared Notes
- [1.7]
- The pSS patients had less beneficial or commensal butyrate-producing bacteria and a higher proportion of opportunistic pathogens with proinflammatory activity, which may impair intestinal barrier function and therefore contribute to inflammatory processes associated with pSS by increasing the production of proinflammatory cytokines and decreasing the release of the anti-inflammatory cytokine IL-10 and the peripheral FOXP3 mRNA expression, implicated in the development and function of regulatory T cells (Treg) cells.
-pSS patients had gut dysbiosis associated with increased serum levels of proinflammatory cytokines including IL-6, IL-12, IL-17 and TNF-alpha (systemic inflammation) and zonulin (intestinal permeability) that resulted in increased systemic microbial exposure.
-At the genera level, gut dysbiosis showed an increase in the abundance of the mucin-degrading and enteric pathogens Prevotella, Clostridium, Enterobacter, Escherichia, and Streptococcus and a depletion in the relative abundance of Bacteroides, Parabacteroides, Faecalibacterium, Roseburia, Ruminococcus, Dorea, Alistipes, Blautia and Bifidobacterium.
- Prevotella contains enzymes that are important in mucin degradation, which may disrupt the colonic mucus barrier and increase intestinal permeability allowing the diffusion of pathogens, toxins, and antigens from the luminal environment into the mucosal tissues and circulatory system, resulting in the immune activation and tissue inflammation important in the onset or progression of several intestinal and chronic autoimmune diseases
Common References
- [1.1] Dysbiotic salivary microbiota in dry mouth and primary Sjögren's syndrome patients [2019] [80001210] [PLOS ONE]
- [1.2] Dysbiosis of the buccal mucosa microbiome in primary Sjögren's syndrome patients [2018] [80000861] [Rheumatology]
- [1.3] Shared gut, but distinct oral microbiota composition in primary Sjögren's syndrome and systemic lupus erythematosus [2018] [80000806] [Journal of Autoimmunity]
- [1.4] Shared gut, but distinct oral microbiota composition in primary Sjögren's syndrome and systemic lupus erythematosus_DUBLICATE [2019] [80000923] [Journal of Autoimmunity]
- [1.5] Saliva microbiome in primary Sjogren's syndrome reveals distinct set of disease associated microbes [2019] [80001246] [Oral Diseases]
- [1.6] Altered mucosal microbiome diversity and disease severity in Sjögren Syndrome [2016] [80000347] [Scientific Reports]
- [1.7] Connection between the Gut Microbiome, Systemic Inflammation, Gut Permeability and FOXP3 Expression in Patients with Primary Sjögren’s Syndrome [2020] [Research] [80001479] [International journal of molecular sciences]
- [1.8] A preliminary study of the oral microbiota in Chinese patients with Sjögren's syndrome [2016] [80000799] [Archives of Oral Biology]
- [1.9] Microbiological and bioinformatics analysis of primary Sjögren's syndrome patients with normal salivation [2016] [80000871] [Journal of Oral Microbiology]
- [1.10] Gut dysbiosis is prevailing in Sjögren's syndrome and is related to dry eye severity [2020] [80001403] [PLOS ONE]
- [1.11] Molecular analysis of oral microflora in patients with primary Sjögren's syndrome by using high-throughput sequencing [2018] [80001013] [PeerJ]