Sjögren syndrome {40000122}

Record Keys
Definition:	Sjögren syndrome
Class:	[ ]

Details
Other Terms:	SJS, SS, PSS
Authoring date:	2020-09-06

Links
Wickipedia Merck Manual

Meta Information
ICD:	[ ]
Category:	Rheumatologic
MedDra ID:	[ ]
MedDra Level:	[ ]

Notes

[ ]

Shared Notes

[1.7]
- The pSS patients had less beneficial or commensal butyrate-producing bacteria and a higher proportion of opportunistic pathogens with proinflammatory activity, which may impair intestinal barrier function and therefore contribute to inflammatory processes associated with pSS by increasing the production of proinflammatory cytokines and decreasing the release of the anti-inflammatory cytokine IL-10 and the peripheral FOXP3 mRNA expression, implicated in the development and function of regulatory T cells (Treg) cells.
-pSS patients had gut dysbiosis associated with increased serum levels of proinflammatory cytokines including IL-6, IL-12, IL-17 and TNF-alpha (systemic inflammation) and zonulin (intestinal permeability) that resulted in increased systemic microbial exposure.
-At the genera level, gut dysbiosis showed an increase in the abundance of the mucin-degrading and enteric pathogens Prevotella, Clostridium, Enterobacter, Escherichia, and Streptococcus and a depletion in the relative abundance of Bacteroides, Parabacteroides, Faecalibacterium, Roseburia, Ruminococcus, Dorea, Alistipes, Blautia and Bifidobacterium.
- Prevotella contains enzymes that are important in mucin degradation, which may disrupt the colonic mucus barrier and increase intestinal permeability allowing the diffusion of pathogens, toxins, and antigens from the luminal environment into the mucosal tissues and circulatory system, resulting in the immune activation and tissue inflammation important in the onset or progression of several intestinal and chronic autoimmune diseases

Common References

[1.1] Dysbiotic salivary microbiota in dry mouth and primary Sjögren's syndrome patients [2019] [80001210] [PLOS ONE]
[1.2] Dysbiosis of the buccal mucosa microbiome in primary Sjögren's syndrome patients [2018] [80000861] [Rheumatology]
[1.3] Shared gut, but distinct oral microbiota composition in primary Sjögren's syndrome and systemic lupus erythematosus [2018] [80000806] [Journal of Autoimmunity]
[1.4] Shared gut, but distinct oral microbiota composition in primary Sjögren's syndrome and systemic lupus erythematosus_DUBLICATE [2019] [80000923] [Journal of Autoimmunity]
[1.5] Saliva microbiome in primary Sjogren's syndrome reveals distinct set of disease associated microbes [2019] [80001246] [Oral Diseases]
[1.6] Altered mucosal microbiome diversity and disease severity in Sjögren Syndrome [2016] [80000347] [Scientific Reports]
[1.7] Connection between the Gut Microbiome, Systemic Inflammation, Gut Permeability and FOXP3 Expression in Patients with Primary Sjögren’s Syndrome [2020] [Research] [80001479] [International journal of molecular sciences]
[1.8] A preliminary study of the oral microbiota in Chinese patients with Sjögren's syndrome [2016] [80000799] [Archives of Oral Biology]
[1.9] Microbiological and bioinformatics analysis of primary Sjögren's syndrome patients with normal salivation [2016] [80000871] [Journal of Oral Microbiology]
[1.10] Gut dysbiosis is prevailing in Sjögren's syndrome and is related to dry eye severity [2020] [80001403] [PLOS ONE]
[1.11] Molecular analysis of oral microflora in patients with primary Sjögren's syndrome by using high-throughput sequencing [2018] [80001013] [PeerJ]

Increased abundance of

‐ Actinomyces lingnae Saliva ‎Human [1.1]

‐ Alloscardovia Buccal swab ‎Human [1.2]

‐ Anaeroglobus Buccal swab ‎Human [1.2]

‐ Atopobium Buccal swab ‎Human [1.2]

‐ Atopobium parvulum Saliva ‎Human [1.1]

‐ Bacteriodes uniformis Faeces ‎Human [1.3, 1.4]

‐ Bacteroides ovatus Faeces ‎Human [1.3, 1.4]

‐ Bacteroides thetaiotaomicron Faeces ‎Human [1.3]

‐ Bacteroides vulgatus Faeces ‎Human [1.3, 1.4]

‐ Bifidobacterium Buccal swab ‎Human [1.2]

‐ Bifidobacterium Saliva ‎Human [1.5]

‐ Blautia Faeces ‎Human [1.6]

‐ Candida albicans ‎Human [1.7]

‐ Clostridium Faeces ‎Human [1.7]

‐ Delftia Oral swab ‎Human [1.8]

‐ Dialister Buccal swab ‎Human [1.2]

‐ Dialister Saliva ‎Human [1.5]

‐ Enterobacter Faeces ‎Human [1.7]

‐ Escherichia Faeces ‎Human [1.6]

‐ Escherichia Faeces ‎Human [1.7]

‐ Fusobacterium nucleatum Saliva ‎Human [1.1]

‐ Lachnoanaerobaculum orale Saliva ‎Human [1.1]

‐ Lactobacillus Saliva ‎Human [1.5]

‐ Lactobacillus Buccal swab ‎Human [1.2]

‐ Lactobacillus Supragingival plaque ‎Human [1.7]

‐ Leucobacter Oral swab ‎Human [1.8]

‐ Megasphaera micronuciformis Saliva ‎Human [1.1]

‐ Mitsuaria Oral swab ‎Human [1.8]

‐ Mitsuokella Saliva ‎Human [1.1]

‐ Oribacterium asaccharolyticum Saliva ‎Human [1.1]

‐ Parvimonas Buccal swab ‎Human [1.2]

‐ Peptostreptococcaceae Buccal swab ‎Human [1.2]

‐ Prevotella ‎Causal Faeces ‎Human [1.7]

‐ Prevotella nanceiensis Saliva ‎Human [1.1]

‐ Prevotella oralis Saliva ‎Human [1.1]

‐ Pseudobutyrivibrio Faeces ‎Human [1.6]

‐ Pseudochrobactrum Oral swab ‎Human [1.8]

‐ Ralstonia Oral swab ‎Human [1.8]

‐ Scardovia Buccal swab ‎Human [1.2]

‐ Staphylococcus aureus ‎Human [1.7]

‐ Streptococcus Tongue scrape sample ‎Human [1.6]

‐ Streptococcus Faeces ‎Human [1.7]

‐ Streptococcus Faeces ‎Human [1.6]

‐ Streptococcus Saliva ‎Human [1.9]

‐ Streptococcus mutans Saliva ‎Human [1.1]

‐ Streptococcus parasanguinis Saliva ‎Human [1.1]

‐ Streptococcus salivarius Saliva ‎Human [1.1]

‐ Streptococcus vestibularis Saliva ‎Human [1.1]

‐ Veillonella Saliva ‎Human [1.9]

‐ Veillonella Faeces ‎Human [1.10]

‐ Veillonella Oral wash ‎Human [1.11]

Decreased abundance of

‐ Abiotrophia Buccal swab ‎Human [1.2]

‐ Actinomyces Oral wash ‎Human [1.11]

‐ Actinomyces Faeces ‎Human [1.3, 1.4]

‐ Agathobacter Faeces ‎Human [1.10]

‐ Alistipes ‎Human [1.7]

‐ Alloprevotella Buccal swab ‎Human [1.2]

‐ Bacteroidaceae Saliva ‎Human [1.9]

‐ Bacteroides ‎Causal Faeces ‎Human [1.6, 1.7]

‐ Bergeyella Buccal swab ‎Human [1.2]

‐ Bergeyella Tongue scrape sample ‎Human [1.6]

‐ Bifidobacterium Faeces ‎Human [1.7, 1.10]

‐ Blautia Faeces ‎Human [1.7, 1.10]

‐ Butyrivibrio Tongue scrape sample ‎Human [1.6]

‐ Catonella morbi Saliva ‎Human [1.9]

‐ Cellulosilyticum ruminicola Buccal swab ‎Human [1.2]

‐ Clostridium Faeces ‎Human [1.4]

‐ Comamonas Oral swab ‎Human [1.8]

‐ Dorea Faeces ‎Human [1.10]

‐ Enterococcus Buccal swab ‎Human [1.2]

‐ Faecalibacterium Faeces ‎Human [1.6, 1.7]

‐ Fretibacterium Saliva ‎Human [1.9]

‐ Fusobacterium Tongue scrape sample ‎Human [1.6]

‐ Fusobacterium Oral swab ‎Human [1.7]

‐ Fusobacterium periodonticum Saliva ‎Human [1.1, 1.9]

‐ Granulicatella Oral swab ‎Human [1.8]

‐ Granulicatella Buccal swab ‎Human [1.2]

‐ Granulicatella adiacens Saliva ‎Human [1.1]

‐ Haemophilus Oral swab ‎Human [1.8]

‐ Haemophilus Oral wash ‎Human [1.11]

‐ Haemophilus Buccal swab ‎Human [1.2]

‐ Lautropia Buccal swab ‎Human [1.2]

‐ Leptotrichia Tongue scrape sample ‎Human [1.6]

‐ Leptotrichia Oral swab ‎Human [1.7]

‐ Leptotrichia Saliva ‎Human [1.5]

‐ Limnohabitans Oral swab ‎Human [1.8]

‐ Moryella Saliva ‎Human [1.9]

‐ Neisseria Oral wash ‎Human [1.11]

‐ Neisseria Oral swab ‎Human [1.8]

‐ Neisseria Buccal swab ‎Human [1.2]

‐ Neisseria flavescens Saliva ‎Human [1.1]

‐ Parabacteroides Faeces ‎Human [1.6, 1.7]

‐ Peptococcus Tongue scrape sample ‎Human [1.6]

‐ Peptostreptococcaceae Saliva ‎Human [1.9]

‐ Peptostreptococcus Oral wash ‎Human [1.11]

‐ Porphyromonas Oral wash ‎Human [1.11]

‐ Porphyromonas gingivalis Saliva ‎Human [1.9, 1.9]

‐ Porphyromonas pasteri Saliva ‎Human [1.1]

‐ Prevotella Faeces ‎Human [1.6]

‐ Prevotella nanceiensis Saliva ‎Human [1.9]

‐ Prevotella pallens Saliva ‎Human [1.9]

‐ Roseburia Faeces ‎Human [1.7]

‐ Rothia Oral wash ‎Human [1.11]

‐ Ruminococcus Faeces ‎Human [1.7]

‐ Stomatobaculum Saliva ‎Human [1.1]

‐ Tanerella forsythia Saliva ‎Human [1.9]

‐ Treponema Saliva ‎Human [1.9]

Sjögren syndrome {40000122}

Record Keys

Details

Links

Meta Information

Notes

Shared Notes

Common References