MetaBiom
Microbiome & Chronic Diseases

Evidence Based Medicine

Liver fibrosis {40000302}

Record Keys


Definition:
Liver fibrosis
Class:[  ]

Details


Other Terms:[  ]
Initialisation date:[  ]

Meta Information


ICD:[  ]
Category:[  ]
MedDra ID:
10019668
MedDra Level:
pt

Notes


[  ]

Shared Notes


  • [1.3
    - Intestinal HDL is not routed to the systemic circulation. Rather, in the form of HDL3, it is directly transported to the liver through the hepatic portal vein.
    - There, it sequesters bacterial lipopolysaccharide from the gut that can trigger inflammation and liver damage.
    - In various models of liver injury, loss of enteric HDL exacerbated pathology.
    - By contrast, drugs elevating intestinal HDL improved disease outcomes.

Common References