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Autism {40000120}

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Definition:
Autism
Class:[  ]

Details


Other Terms:
Autism Spectrum Disorders, ASD
Initialisation date:
2019-06-23

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ICD:[  ]
Category:
Psychiatry, Pediatric
MedDra ID:
10080683
MedDra Level:[  ]

Notes


- Twenty-seven of their 313 metabolites in faeces and serum were also different, and of the 313, two – 5-aminovaleric acid (5AV) and taurine – were also present in lower quantities. These two molecules are neurotransmitter agonists: their molecular structures resemble that of the GABA and glycine neurotransmitters, and they interfere with the latter’s functions.” As it happens, both GABA and glycine, help the brain develop normally.
And when the scientists injected the mice with 5AV and taurine, the rodents developed ASD-like symptoms. Ergo, bacteria probably interfere with brain functions using these molecules. (1)


- Members of the C. histolyticum group are recognized toxin-producers and may contribute towards gut dysfunction, with their metabolic products also exerting systemic effects.
- Strategies to reduce clostridial population levels harboured by ASD patients or to improve their gut microflora profile through dietary modulation may help to alleviate gut disorders common in such patients. (3)

- L. reuteri produces a metabolite that activates the vagus nerve to promote oxytocin, the cuddle hormone.This hormone then turns on the brain reward center for social behavior. Impeding the message at any point along this relay from bacteria to metabolite to vagus nerve to oxytocin receptors impairs the animals sociability (4)

- Blood of mice with autism symptoms had levels of a chemical called 4-ethylphenylsulphate (4EPS) that were 46 times higher than that of the control group. This substance is structurally similar to a chemical called para-cresol that is elevated in people with autism .
- When the researchers injected 4EPS into wild-type mice, they started behaving like the untreated autistic mice - obsessively repeating some behaviours and squeaking differently when greeting other mice. (5)

- ASD mice were fed with Bacteroides fragilis, a gut microbe with positive effects on the immune system, the abundance of 34% of these metabolites changed back, gut barrier integrity was improved, the gut-microbiome was restored to a non-ASD state, and ASD-related behavioral abnormalities were ameliorated. In addition, a 46-fold increase of 4-ethylphenylsulfate (4-EPS) in the serum of MIA offspring returned to normal levels.
-A second metabolite elevated in the MIA serum, and normalized by treatment with B. fragilis, was indolepyruvate. Indolepyruvate is generated by microbial tryptophan catabolism and is related to indolyl-3-acryloylglycine, another human autism marker. Indolepyruvate elevation could be linked to increased serum levels of serotonin, yet another human autism biomarker.
- Application of the B. fragilis probiotic, increased many other metabolites including N-acetylserine, which the authors hypothesize may provide protection against some ASD symptoms. (6)

- Bifidobacterium, Blautia, Dialister, Prevotella, Veillonella, and Turicibacter were consistently decreased, while Lactobacillus, Bacteroides, Desulfovibrio, and Clostridium were increased in patients with ASD relative to HCs in certain studies. (7)

Shared Notes


  • [1.25
    - There is a high coincidence of gastrointestinal (GI) symptoms and compositional changes within the gut microbiome in individuals with ASD.
    - The degree of GI symptomatology, including constipation and diarrhea, may correlate with the severity of ASD.
    - Microbiome-induced inflammation’s potential to alter the blood-brain barrier (BBB) permeability.
    - The same factors affecting gut permeability also affect the permeability of the BBB.
    - The translocation of pro-inflammatory molecules across the intestinal barrier causes a low-grade systemic inflammatory response, which can alter the BBB’s permeability
  • [1.26
    - Specifically, Bacteroidetes, Bacteroides, and Parabacteroides were decreased in oASD mice, with an increase in Akkermansia, Sutterella, and Lachnospiraceae, as has been reported in humans.
    - Both the Bacteroides spp. (b20cd_Bacteroides) and P. merdae (4ae7e_Parabacteroides) correlated with reduced repetitive behavior and increased social behavior.
    - E. tayi (02b40_Lachnospiraceae) showed the opposite effects, as it correlated with increased repetitive behavior and social interaction deficits
    - P. merdae, were more abundant in ASD individuals from human.
  • [1.27
    - In autism patient Bacteroides, Bifidobacterium, Escherichia coli are reduces and Faecalibacterium, Lactobacillus are increased. The presence of Clostridium remains substantially unchanged
  • - Increase in Faecalibacterium in ASD children is responsible for the progression of inflammatory processes, with increased levels of type I interferon, and the alteration of the intestinal barrier.
  • - The reduction of Bifidobacterium also results in reduced levels of short-chain fatty acids (SCFAs), common in ASD children.
  • - Autism patients who have had their intestinal microbiota remodeled through the administration of antibiotics or bacterial transfer therapy in the intestine, presented with attenuated symptoms of ASD
  • [1.28
    - Treatment with L. reuteri selectively rescues social deficits in genetic, environmental, and idiopathic ASD models.
    - The effects of L. reuteri on social behavior are not mediated by restoring the composition of the host gut microbiome, which is altered in all of these ASD models.
    - L. reuteri acts in a vagus nerve-dependent manner and rescues social interaction-induced synaptic plasticity in the ventral tegmental area of ASD mice, but not in oxytocin receptor-deficient mice
  • [1.24
    - Host genetics and microbiota differentially regulate behaviors in an ASD mouse model
    - Microbe therapy (L. reuteri) rescues social deficits in ASD mouse model but not hyperactivity
    - Microbe-induced metabolite tetrahydrobiopterin (BH4) selectively rescues social deficits in ASD mouse model
    - L. reuteri and tetrahydrobiopterin (BH4) improves in ASD mouse model social-reward-mediated synaptic transmission
  • [1.29
    - Autism incidence has been found to be higher in the C. difficile diseased population.
  • [1.30
    - The microbial metabolite p-Cresol induces selectively ASD core behavioral symptoms in mice.
    - Social behavior deficits induced by p-Cresol are dependant on changes in microbiota composition.
  • [1.31
    - There is an increased frequency of serum auto-antibodies against folate receptor alpha (FRAA) in autism spectrum disorder children.
  • [1.32
    - L. reuteri produces a metabolite that activates the vagus nerve to promote oxytocin, the cuddle hormone.This hormone then turns on the brain reward center for social behavior. Impeding the message at any point along this relay from bacteria to metabolite to vagus nerve to oxytocin receptors impairs the animals sociability.


[Overlap other Diseases]

DiseaseOverlapCommon increased OrganismCommon decreased Organism
Autism 1.0000 111 (1.00) : Acidobacteria | Aerococcus | Akkermansia | Akkermansia muciniphila | Alistipes indistinctus | Alistipes putredinis | Alistipes shahii | Allisonella | Anaerofilum | Bacillus | Bacteroides | Bacteroides fragilis | Bacteroides intestinalis | Bacteroides stercoris | Bacteroides vulgatus | Barnesiella | Barnesiella intestinihominis | Bifidobacterium | Bilophila | Blautia faecis | Burkholderia | Butyricimonas | Caloramator | Candida | Cardiobacterium | Clostridia cluster I | Clostridioides difficile | Clostridium | Clostridium aminobutyricum | Clostridium aminophilum | Clostridium asparagiform | Clostridium boltae | Clostridium botulinum | Clostridium clostridioforme | Clostridium cocleatum | Clostridium hathewayi | Clostridium histolyticum | Clostridium innocuum | Clostridium ramosum | Clostridium scindens | Clostridium subterminale | Clostridium symbiosum | Collinsella | Constrictibacter | Corynebacterium | Desulfohalobium | Desulfovibrio | Dichelobacter | Dorea | Eggerthella lenta | Enterobacter hormaechei | Ent 125 (1.00) : Actinomyces | Adlercreutzia | Akkermansia | Alistipes | Alistipes onderdonkii | Alloprevotella | Anaerostipes | Anaerotruncus | Atopobium | Bacteriodes uniformis | Bacteroides | Bacteroides coprocola | Bacteroides fragilis | Bacteroides massiliensis | Bacteroides vulgatus | Bacteroidetes | Barnesiella | Bifidobacterium | Bifidobacterium adolescentis | Bifidobacterium angulatum | Bifidobacterium longum | Bilophila | Blautia | Bulleidia | Butyricicoccus | Butyricimonas | Butyrivibrio | Campylobacter jejuni | Candidatus soleaferrea | Carboxydothermus | Catonella | Chloracidobacterium thermophilum B | Christensenella | Clostridiaceae | Clostridium bartletti | Clostridium butyricum | Clostridium disporicum | Clostridium leptum | Clostridium methylpentosum | Clostridium perfringens | Clostridium spiroforme | Clostridium tertium | Collinsella | Coprococcus | Coraliomargarita akajimensis | Coriobacteriaceae | Corynebacterium | Dialister | Dialister invisus | Diaphorobacter | Eggerthella | Eggerthella lenta | Enteroba
Crohn's disease 0.0885 27 (0.05) : Bacteroides fragilis | Bacteroides vulgatus | Bifidobacterium | Burkholderia | Candida | Clostridioides difficile | Clostridium | Clostridium boltae | Clostridium ramosum | Collinsella | Enterobacteriaceae | Enterococcus | Faecalibacterium prausnitzii | Flavonifractor plautii | Haemophilus | Lachnobacterium | Lachnospiraceae | Lactobacillus | Odoribacter | Parabacteroides distasonis | Pseudomonas | Rothia | Ruminococcus | Ruminococcus gnavus | Ruminococcus torques | Shigella | Streptococcus 51 (0.13) : Adlercreutzia | Akkermansia | Alistipes | Anaerostipes | Anaerotruncus | Bacteriodes uniformis | Bacteroides | Bacteroides fragilis | Bacteroides massiliensis | Bacteroides vulgatus | Bacteroidetes | Bifidobacterium | Bifidobacterium adolescentis | Bifidobacterium longum | Bilophila | Blautia | Butyricimonas | Christensenella | Clostridium disporicum | Clostridium leptum | Clostridium perfringens | Collinsella | Coprococcus | Coriobacteriaceae | Dialister | Dialister invisus | Enterococcus | Erysipelotrichaceae | Eubacterium rectale | Eubacterium ventriosum | Faecalibacterium prausnitzii | Lachnospiraceae | Lactobacillus | Mogibacterium | Odoribacter | Oscillospira | Parabacteroides | Peptococcus | Phascolarctobacterium | Prevotella | Roseburia | Roseburia faecis | Roseburia intestinalis | Ruminiclostridium | Ruminococcaceae | Ruminococcus albus | Streptococcus | Streptococcus salivarius | Subdoligranulum | Turicibacter | Veillonellaceae
Obesity 0.0843 23 (0.05) : Bacillus | Bacteroides | Bacteroides fragilis | Bacteroides vulgatus | Bifidobacterium | Bilophila | Clostridium | Clostridium symbiosum | Collinsella | Corynebacterium | Faecalibacterium prausnitzii | Haemophilus | Klebsiella pneumoniae | Lachnospira | Lactobacillus | Lactococcus | Megamonas | Parabacteroides | Peptostreptococcaceae | Prevotella copri | Pseudomonas | Roseburia | Ruminococcus torques 41 (0.12) : Akkermansia | Alistipes | Alloprevotella | Anaerostipes | Anaerotruncus | Atopobium | Bacteriodes uniformis | Bacteroides | Bacteroides vulgatus | Bacteroidetes | Barnesiella | Bifidobacterium | Bifidobacterium adolescentis | Bifidobacterium longum | Blautia | Bulleidia | Butyricimonas | Clostridium disporicum | Clostridium leptum | Coprococcus | Coriobacteriaceae | Dialister | Faecalibacterium prausnitzii | Fusobacterium | Haemophilus parainfluenzae | Lachnospiraceae | Lactobacillus | Lautropia mirabilis | Odoribacter | Oscillospira | Parabacteroides | Phascolarctobacterium | Prevotella | Roseburia | Rothia | Ruminiclostridium | Ruminococcaceae | Selenomonas | Solobacterium | Streptococcus | Veillonella
Ulcerative Colitis 0.0777 29 (0.10) : Akkermansia | Bacteroides | Bacteroides fragilis | Bacteroides vulgatus | Bifidobacterium | Burkholderia | Clostridioides difficile | Clostridium | Clostridium ramosum | Desulfovibrio | Dorea | Enterobacteriaceae | Enterococcus | Flavonifractor plautii | Haemophilus | Lachnospira | Lactobacillus | Mitsuokella | Peptostreptococcaceae | Roseburia | Rothia | Ruminococcaceae | Ruminococcus | Ruminococcus gnavus | Ruminococcus torques | Shigella | Streptococcus | Sutterella | Sutterella wadsworthensis 26 (0.06) : Alistipes | Bacteroides | Bacteroides fragilis | Bacteroides massiliensis | Bifidobacterium | Bilophila | Blautia | Butyricimonas | Christensenella | Clostridium leptum | Coprococcus | Coriobacteriaceae | Dialister | Enterococcus | Eubacterium rectale | Faecalibacterium prausnitzii | Lachnospiraceae | Lactobacillus | Mogibacterium | Odoribacter | Oscillospira | Peptococcus | Phascolarctobacterium | Prevotella | Roseburia | Streptococcus
Clostridium difficile infection 0.0770 14 (0.06) : Akkermansia | Akkermansia muciniphila | Clostridioides difficile | Clostridium | Corynebacterium | Dorea | Enterobacteriaceae | Enterococcus | Lactobacillus | Parabacteroides | Peptostreptococcaceae | Ruminococcus | Shigella | Sutterella 19 (0.09) : Akkermansia | Alistipes | Anaerostipes | Anaerotruncus | Bacteroides | Barnesiella | Bifidobacterium | Butyricimonas | Collinsella | Coprococcus | Coriobacteriaceae | Dialister | Faecalibacterium prausnitzii | Odoribacter | Oscillospira | Phascolarctobacterium | Prevotella | Ruminococcaceae | Subdoligranulum
Type 2 diabetes 0.0728 27 (0.06) : Akkermansia muciniphila | Bacteroides | Bacteroides intestinalis | Bifidobacterium | Burkholderia | Clostridium boltae | Clostridium clostridioforme | Clostridium hathewayi | Clostridium ramosum | Clostridium symbiosum | Corynebacterium | Dorea | Eggerthella lenta | Enterococcus | Haemophilus | Lachnospiraceae | Lactobacillus | Lactobacillus reuteri | Megasphaera | Parabacteroides | Parabacteroides distasonis | Pseudomonas | Roseburia | Ruminococcaceae | Ruminococcus gnavus | Shigella | Streptococcus 32 (0.09) : Adlercreutzia | Akkermansia | Anaerostipes | Atopobium | Bacteriodes uniformis | Bacteroides vulgatus | Bifidobacterium | Bifidobacterium adolescentis | Bilophila | Butyricimonas | Clostridium bartletti | Clostridium butyricum | Clostridium leptum | Collinsella | Coprococcus | Dialister invisus | Erysipelotrichaceae | Eubacterium rectale | Faecalibacterium prausnitzii | Fusobacterium | Haemophilus parainfluenzae | Lachnospiraceae | Odoribacter | Oscillospira | Parabacteroides | Peptoniphilus | Phascolarctobacterium | Prevotella | Roseburia intestinalis | Ruminococcus lactaris | Streptococcus | Terrisporobacter glycolicus
Short Bowel Syndrome 0.0710 7 (0.02) : Enterobacteriaceae | Enterococcus | Haemophilus | Lactobacillus | Megasphaera | Shigella | Streptococcus 23 (0.12) : Akkermansia | Alistipes | Anaerostipes | Bacteroides | Bacteroidetes | Blautia | Clostridium leptum | Collinsella | Eggerthella | Erysipelotrichaceae | Flavonifractor | Fusicatenibacter | Lachnoclostridium | Lachnospiraceae | Lactobacillus | Parabacteroides | Peptostreptococcaceae | Prevotella | Roseburia | Ruminiclostridium | Ruminococcaceae | Tyzzerella | Veillonella
Alcoholism 0.0707 20 (0.07) : Bacteroides | Bilophila | Cardiobacterium | Clostridium | Collinsella | Corynebacterium | Desulfovibrio | Enterobacteriaceae | Enterococcus | Haemophilus | Holdemania | Klebsiella pneumoniae | Lachnospiraceae | Lactobacillus | Megamonas | Odoribacter | Parabacteroides | Rothia | Streptococcus | Sutterella 15 (0.07) : Adlercreutzia | Akkermansia | Anaerostipes | Bacteroidetes | Bifidobacterium | Blautia | Collinsella | Coprococcus | Coriobacteriaceae | Lachnospiraceae | Odoribacter | Oribacterium | Peptococcus | Porphyromonas | Prevotella
Chronic kidney disease 0.0688 15 (0.04) : Bacillus | Bacteroides | Bifidobacterium | Clostridium innocuum | Corynebacterium | Desulfovibrio | Enterobacteriaceae | Lactobacillus | Parabacteroides | Pseudomonas | Rothia | Ruminococcus gnavus | Ruminococcus torques | Shigella | Streptococcus 25 (0.10) : Akkermansia | Bacteroides | Bacteroides fragilis | Barnesiella | Bifidobacterium | Butyricicoccus | Collinsella | Coprococcus | Corynebacterium | Dialister | Enterococcus | Escherichia coli | Eubacterium coprostanoligenes | Eubacterium rectale | Faecalibacterium prausnitzii | Oribacterium | Prevotella | Prevotellaceae | Romboutsia | Roseburia | Ruminococcaceae | Shigella | Streptococcus | Subdoligranulum | Tyzzerella
Colorectal cancer 0.0681 23 (0.04) : Akkermansia | Akkermansia muciniphila | Bacteroides | Bacteroides fragilis | Bifidobacterium | Burkholderia | Clostridioides difficile | Clostridium ramosum | Clostridium symbiosum | Collinsella | Desulfovibrio | Enterobacteriaceae | Enterococcus | Klebsiella pneumoniae | Lactobacillus | Lactococcus | Pseudomonas | Roseburia | Roseburia intestinalis | Roseburia inulinivorans | Ruminococcaceae | Ruminococcus | Streptococcus 37 (0.10) : Actinomyces | Akkermansia | Alistipes | Alloprevotella | Anaerostipes | Anaerotruncus | Atopobium | Bacteriodes uniformis | Bacteroides | Bacteroides fragilis | Bifidobacterium | Blautia | Christensenella | Clostridium leptum | Collinsella | Coprococcus | Dialister | Dialister invisus | Eubacterium eligens | Eubacterium rectale | Eubacterium ventriosum | Faecalibacterium prausnitzii | Lachnoanaerobaculum | Lachnoclostridium | Lachnospiraceae | Lactobacillus | Mogibacterium | Parabacteroides | Parvimonas | Phascolarctobacterium | Prevotella | Roseburia | Ruminococcaceae | Ruminococcus albus | Ruminococcus obeum | Streptococcus | Streptococcus salivarius
Pervasive developmental disorder NOS 0.0635 9 (0.05) : Alistipes putredinis | Alistipes shahii | Anaerofilum | Bacteroides fragilis | Collinsella | Dorea | Faecalibacterium prausnitzii | Roseburia inulinivorans | Streptococcus thermophiles 15 (0.08) : Bacteriodes uniformis | Bacteroides vulgatus | Clostridium bartletti | Clostridium methylpentosum | Escherichia coli | Eubacterium eligens | Fusobacterium | Oscillospira | Parabacteroides | Roseburia faecis | Roseburia intestinalis | Sporobacter termitidis | Streptococcus salivarius | Subdoligranulum | Tyzzerella nexilis
Cystic fibrosis 0.0630 13 (0.04) : Bacillus | Bacteroides | Clostridioides difficile | Clostridium clostridioforme | Enterobacteriaceae | Enterococcus | Klebsiella pneumoniae | Lachnospiraceae | Megasphaera | Pseudomonas | Ruminococcus gnavus | Shigella | Streptococcus 33 (0.09) : Actinomyces | Alistipes | Alloprevotella | Bacteriodes uniformis | Bacteroides | Bacteroides vulgatus | Bacteroidetes | Bifidobacterium | Bifidobacterium adolescentis | Blautia | Butyrivibrio | Corynebacterium | Dialister | Dialister invisus | Erysipelotrichaceae | Eubacterium eligens | Eubacterium rectale | Faecalibacterium prausnitzii | Fusobacterium | Lachnoanaerobaculum | Lachnospiraceae | Odoribacter | Peptococcus | Porphyromonas | Prevotella | Prevotellaceae | Roseburia | Roseburia intestinalis | Rothia | Ruminococcaceae | Shigella | Treponema | Veillonella
Coronary artery disease 0.0608 17 (0.06) : Akkermansia | Bacteroides | Butyricimonas | Collinsella | Desulfovibrio | Enterococcus | Haemophilus | Lactobacillus | Lactococcus | Megamonas | Megasphaera | Odoribacter | Parabacteroides distasonis | Pseudomonas | Ruminococcus gnavus | Shigella | Streptococcus 15 (0.06) : Bacteroides | Blautia | Clostridiaceae | Coprococcus | Eggerthella | Erysipelotrichaceae | Eubacterium rectale | Flavonifractor | Fusicatenibacter | Lachnospiraceae | Roseburia | Ruminococcaceae | Streptococcus | Subdoligranulum | Veillonella
Alzheimer's disease 0.0604 13 (0.05) : Bacteroides | Bacteroides vulgatus | Bifidobacterium | Bilophila | Dorea | Enterobacteriaceae | Lactobacillus | Odoribacter splanchnicus | Pseudomonas | Ruminococcaceae | Shigella | Streptococcus | Veillonellaceae 16 (0.07) : Adlercreutzia | Alistipes | Bacteroides | Bacteroides fragilis | Bacteroidetes | Bifidobacterium | Blautia | Clostridiaceae | Dialister | Eubacterium rectale | Lachnoclostridium | Lachnospiraceae | Parabacteroides | Subdoligranulum | Turicibacter | Veillonellaceae
Irritable bowel syndrome 0.0588 21 (0.06) : Allisonella | Bacteroides | Bifidobacterium | Butyricimonas | Clostridioides difficile | Clostridium symbiosum | Collinsella | Dorea | Enterobacteriaceae | Enterococcus | Faecalibacterium prausnitzii | Flavonifractor plautii | Holdemania | Lachnospira | Lactobacillus | Odoribacter | Oxalobacter | Roseburia | Ruminococcus gnavus | Streptococcus | Veillonellaceae 22 (0.06) : Alistipes | Anaerostipes | Bacteriodes uniformis | Bacteroides | Bacteroides fragilis | Bacteroides vulgatus | Bifidobacterium | Blautia | Butyricicoccus | Coprococcus | Fusobacterium | Lachnospiraceae | Lactobacillus | Odoribacter | Oribacterium | Parabacteroides | Prevotellaceae | Roseburia | Ruminococcaceae | Streptococcus | Tannerella | Veillonella
Hepatocellular cancer 0.0575 19 (0.06) : Akkermansia | Allisonella | Bacteroides | Barnesiella | Bilophila | Clostridium | Collinsella | Dorea | Enterococcus | Holdemania | Lachnospira | Lachnospiraceae | Odoribacter | Parabacteroides | Pseudomonas | Ruminococcaceae | Ruminococcus | Shigella | Streptococcus 12 (0.05) : Adlercreutzia | Akkermansia | Bacteroidetes | Bifidobacterium | Collinsella | Dialister | Enterococcus | Lactobacillus | Peptococcus | Phascolarctobacterium | Rothia | Streptococcus
Non-alcoholic fatty liver disease 0.0569 11 (0.03) : Akkermansia | Bacteroides | Dorea | Enterobacteriaceae | Enterococcus | Klebsiella pneumoniae | Lachnospiraceae | Lactobacillus | Roseburia | Ruminococcus | Streptococcus 24 (0.08) : Alistipes | Anaerostipes | Anaerotruncus | Bacteroides | Bacteroides fragilis | Bifidobacterium adolescentis | Bifidobacterium longum | Bilophila | Blautia | Coprococcus | Erysipelotrichaceae | Faecalibacterium prausnitzii | Flavonifractor | Lactobacillus | Mogibacterium | Odoribacter | Oscillospira | Parabacteroides | Peptostreptococcaceae | Prevotella | Roseburia | Ruminiclostridium | Ruminococcaceae | Turicibacter
HIV infection 0.0559 12 (0.02) : Allisonella | Barnesiella | Candida | Corynebacterium | Enterobacteriaceae | Haemophilus | Lactobacillus | Oscillospira | Prevotella copri | Ruminococcus | Shigella | Streptococcus 29 (0.10) : Akkermansia | Alistipes | Bacteroides | Bacteroidetes | Barnesiella | Bifidobacterium | Bilophila | Blautia | Butyrivibrio | Collinsella | Coprococcus | Dialister | Eggerthella | Flavonifractor | Fusobacterium | Lachnospiraceae | Odoribacter | Oscillospira | Parabacteroides | Parvimonas | Peptostreptococcaceae | Prevotella | Romboutsia | Roseburia | Ruminococcaceae | Shigella | Streptococcus | Turicibacter | Veillonella
Parkinson's Disease 0.0542 32 (0.07) : Akkermansia | Akkermansia muciniphila | Alistipes shahii | Bacteroides | Barnesiella | Bifidobacterium | Bilophila | Butyricimonas | Desulfovibrio | Eggerthella lenta | Enterobacteriaceae | Enterococcus | Holdemania | Lachnobacterium | Lachnospira | Lachnospiraceae | Lactobacillus | Lactobacillus reuteri | Lactococcus | Odoribacter | Oscillospira | Parabacteroides | Parabacteroides merdae | Pasteurellaceae | Prevotella copri | Roseburia | Roseburia inulinivorans | Ruminococcaceae | Ruminococcus | Ruminococcus torques | Shigella | Streptococcus 22 (0.04) : Actinomyces | Bacteroides coprocola | Bacteroides fragilis | Bacteroides massiliensis | Blautia | Bulleidia | Clostridium leptum | Collinsella | Coprococcus | Corynebacterium | Faecalibacterium prausnitzii | Lachnospiraceae | Lactobacillus | Prevotella | Prevotellaceae | Roseburia | Roseburia intestinalis | Rothia | Ruminococcaceae | Streptococcus | Tyzzerella | Veillonella
Primary sclerosing cholangitis-IBD 0.0532 16 (0.07) : Bifidobacterium | Clostridium | Collinsella | Corynebacterium | Enterococcus | Haemophilus | Lachnospira | Lachnospiraceae | Lactobacillus | Megamonas | Megasphaera | Oscillospira | Roseburia | Rothia | Ruminococcus | Streptococcus 8 (0.04) : Bacteroides | Blautia | Faecalibacterium prausnitzii | Parabacteroides | Phascolarctobacterium | Prevotella | Roseburia | Veillonella
Hypertension 0.0513 13 (0.07) : Akkermansia | Alistipes indistinctus | Bifidobacterium | Clostridium | Desulfovibrio | Dorea | Lactobacillus | Megasphaera | Parabacteroides | Prevotella copri | Ruminococcaceae | Shigella | Streptococcus 10 (0.04) : Bifidobacterium | Blautia | Butyrivibrio | Coprococcus | Enterococcus | Eubacterium rectale | Odoribacter | Oscillospira | Roseburia | Veillonella
Multiple Sclerosis 0.0506 19 (0.06) : Akkermansia | Akkermansia muciniphila | Bacteroides | Bacteroides fragilis | Bifidobacterium | Clostridium | Collinsella | Desulfovibrio | Dorea | Eggerthella lenta | Haemophilus | Holdemania | Lactobacillus | Lactobacillus reuteri | Parabacteroides | Ruminococcus | Shigella | Streptococcus | Streptococcus thermophiles 14 (0.04) : Bacteroides | Bacteroides coprocola | Blautia | Butyricicoccus | Butyricimonas | Dialister | Erysipelotrichaceae | Eubacterium rectale | Faecalibacterium prausnitzii | Intestinibacter | Lachnospiraceae | Prevotella | Roseburia | Ruminococcaceae
Cirrhosis 0.0479 18 (0.05) : Akkermansia | Bacteroides | Bacteroides vulgatus | Burkholderia | Clostridium | Enterobacteriaceae | Enterococcus | Haemophilus | Lactobacillus | Megasphaera | Parabacteroides | Pasteurellaceae | Peptostreptococcaceae | Pseudomonas | Ruminococcus | Ruminococcus gnavus | Streptococcus | Veillonellaceae 22 (0.05) : Actinomyces | Akkermansia | Bacteriodes uniformis | Bacteroides | Bifidobacterium | Bifidobacterium longum | Blautia | Clostridiaceae | Coriobacteriaceae | Eubacterium eligens | Eubacterium rectale | Faecalibacterium prausnitzii | Lachnoanaerobaculum | Lachnospiraceae | Mogibacterium | Prevotella | Roseburia faecis | Roseburia intestinalis | Ruminococcaceae | Selenomonas | Subdoligranulum | Veillonellaceae
Migraine 0.0459 12 (0.08) : Clostridium asparagiform | Clostridium boltae | Clostridium clostridioforme | Clostridium hathewayi | Clostridium ramosum | Clostridium symbiosum | Eggerthella lenta | Flavonifractor plautii | Lachnospiraceae | Pseudomonas | Ruminococcus gnavus | Streptococcus 2 (0.01) : Bifidobacterium adolescentis | Faecalibacterium prausnitzii
Hepatitis B 0.0444 9 (0.04) : Bacteroides | Clostridium | Desulfovibrio | Enterobacteriaceae | Haemophilus | Lactobacillus | Megamonas | Ruminococcus | Streptococcus 12 (0.05) : Alistipes | Alistipes onderdonkii | Anaerostipes | Bacteroides | Bifidobacterium | Butyricimonas | Corynebacterium | Escherichia | Faecalibacterium prausnitzii | Parabacteroides | Phascolarctobacterium | Prevotella
Ankylosing spondylitis 0.0417 13 (0.06) : Bifidobacterium | Collinsella | Corynebacterium | Dorea | Flavonifractor plautii | Lachnospiraceae | Megamonas | Megasphaera | Parabacteroides distasonis | Rothia | Ruminococcaceae | Streptococcus | Sutterella 8 (0.03) : Butyrivibrio | Enterococcus | Fusobacterium | Odoribacter | Parabacteroides | Prevotellaceae | Roseburia | Veillonellaceae
Lung cancer 0.0405 10 (0.04) : Bacteroides | Bifidobacterium | Butyricimonas | Enterobacteriaceae | Enterococcus | Lachnospiraceae | Odoribacter | Parabacteroides distasonis | Ruminococcus gnavus | Streptococcus 10 (0.04) : Bifidobacterium | Bifidobacterium adolescentis | Bifidobacterium longum | Coriobacteriaceae | Diaphorobacter | Erysipelotrichaceae | Faecalibacterium prausnitzii | Parabacteroides | Roseburia faecis | Streptococcus
Type 1 diabetes 0.0403 11 (0.03) : Alistipes shahii | Bacteroides | Bacteroides fragilis | Bacteroides vulgatus | Bifidobacterium | Candida | Clostridium | Enterobacteriaceae | Ruminococcus | Streptococcus | Sutterella 16 (0.05) : Akkermansia | Alistipes | Anaerostipes | Bacteroides fragilis | Bacteroides vulgatus | Bifidobacterium | Dialister | Eubacterium eligens | Eubacterium rectale | Faecalibacterium prausnitzii | Lachnospiraceae | Lactobacillus | Peptostreptococcaceae | Prevotella | Roseburia | Roseburia faecis
Non alcoholic steatohepatitis 0.0394 4 (0.01) : Dorea | Lactobacillus | Megamonas | Ruminococcus 11 (0.07) : Alistipes | Bacteroidetes | Bifidobacterium | Bifidobacterium adolescentis | Bifidobacterium longum | Blautia | Clostridium leptum | Coprococcus | Oscillospira | Roseburia | Ruminococcaceae
Celiac Disease 0.0390 9 (0.02) : Bacteroides | Bacteroides vulgatus | Dorea | Enterobacteriaceae | Lachnospiraceae | Lactobacillus | Megasphaera | Parabacteroides distasonis | Shigella 17 (0.06) : Actinomyces | Akkermansia | Anaerostipes | Bacteroidetes | Bifidobacterium | Blautia | Enterococcus | Faecalibacterium prausnitzii | Intestinibacter | Lachnospiraceae | Lactobacillus | Mogibacterium | Parvimonas | Peptostreptococcaceae | Prevotella | Selenomonas | Veillonellaceae
Alcoholic Hepatitis 0.0382 12 (0.05) : Bifidobacterium | Candida | Dorea | Enterobacteriaceae | Enterococcus | Haemophilus | Lactobacillus | Lactococcus | Neisseriaceae | Peptostreptococcaceae | Rothia | Streptococcus 8 (0.03) : Akkermansia | Bacteroides | Bacteroidetes | Bilophila | Odoribacter | Oscillospira | Parabacteroides | Prevotella
Inflamatory bowel disease 0.0381 8 (0.02) : Bacteroides fragilis | Bacteroides vulgatus | Butyricimonas | Clostridium hathewayi | Enterobacteriaceae | Enterococcus | Ruminococcus gnavus | Ruminococcus torques 14 (0.05) : Alistipes | Anaerostipes | Bacteroides | Barnesiella | Bifidobacterium | Blautia | Coprococcus | Coriobacteriaceae | Eubacterium rectale | Faecalibacterium prausnitzii | Mogibacterium | Parabacteroides | Prevotella | Ruminococcaceae
Kidney stone 0.0381 9 (0.03) : Bacteroides | Bacteroides fragilis | Lachnospiraceae | Megamonas | Parabacteroides | Parabacteroides distasonis | Prevotella copri | Shigella | Sutterella 10 (0.04) : Anaerostipes | Bilophila | Dialister | Eubacterium ruminantium | Fusicatenibacter | Lactobacillus | Peptoniphilus | Prevotella | Ruminiclostridium | Subdoligranulum
Covid-19 0.0377 4 (0.01) : Clostridium hathewayi | Clostridium ramosum | Rothia | Streptococcus 12 (0.07) : Anaerostipes | Blautia | Coprococcus | Eubacterium rectale | Eubacterium ventriosum | Faecalibacterium prausnitzii | Fusicatenibacter | Lachnospiraceae | Romboutsia | Roseburia | Ruminococcaceae | Ruminococcus obeum
Atopic Dermatitis 0.0374 9 (0.03) : Bacteroides | Clostridioides difficile | Corynebacterium | Faecalibacterium prausnitzii | Lactobacillus | Oscillospira | Parabacteroides | Streptococcus | Sutterella 16 (0.05) : Actinomyces | Akkermansia | Atopobium | Bacteroides fragilis | Bacteroides vulgatus | Bifidobacterium | Blautia | Bulleidia | Coprococcus | Corynebacterium | Eggerthella | Enterococcus | Lactobacillus | Porphyromonas | Streptococcus | Veillonella
Sjögren syndrome 0.0368 7 (0.01) : Bacteroides vulgatus | Bifidobacterium | Clostridium | Lactobacillus | Mitsuokella | Peptostreptococcaceae | Streptococcus 19 (0.06) : Actinomyces | Alistipes | Alloprevotella | Bacteroides | Bifidobacterium | Blautia | Butyrivibrio | Enterococcus | Fusobacterium | Parabacteroides | Peptococcus | Peptostreptococcaceae | Peptostreptococcus | Porphyromonas | Prevotella | Roseburia | Rothia | Stomatobaculum | Treponema
Helicobacter pylori infection 0.0357 7 (0.02) : Butyricimonas | Desulfovibrio | Enterococcus | Haemophilus | Klebsiella pneumoniae | Oxalobacter | Prevotella copri 11 (0.05) : Actinomyces | Alloprevotella | Bacteroides vulgatus | Bacteroidetes | Escherichia coli | Fusobacterium | Parvimonas | Peptococcus | Roseburia | Rothia | Streptococcus
Glycogen storage disease 0.0357 4 (0.03) : Bifidobacterium | Lactobacillus | Ruminococcus gnavus | Shigella 8 (0.04) : Alistipes | Anaerostipes | Barnesiella | Blautia | Coprococcus | Odoribacter | Phascolarctobacterium | Roseburia
Chronic alcoholic pancreatitis 0.0356 5 (0.02) : Clostridium | Enterococcus | Mitsuokella | Pseudomonas | Streptococcus 11 (0.05) : Anaerostipes | Bacteroides | Bilophila | Blautia | Dialister | Fusobacterium | Odoribacter | Oscillospira | Parabacteroides | Prevotella | Roseburia
Primary biliary cholangitis 0.0351 6 (0.02) : Clostridium | Enterobacteriaceae | Haemophilus | Lactobacillus | Pseudomonas | Streptococcus 10 (0.05) : Akkermansia | Bacteroides | Bacteroidetes | Blautia | Butyricimonas | Dialister | Fusobacterium | Odoribacter | Oscillospira | Phascolarctobacterium
Pulmonary tubercolosis 0.0339 6 (0.01) : Clostridium boltae | Collinsella | Faecalibacterium prausnitzii | Lactobacillus | Roseburia inulinivorans | Streptococcus 15 (0.06) : Alloprevotella | Bacteroidetes | Bifidobacterium adolescentis | Bifidobacterium longum | Coprococcus | Eubacterium eligens | Eubacterium rectale | Haemophilus parainfluenzae | Prevotella | Roseburia | Roseburia intestinalis | Ruminococcus lactaris | Ruminococcus obeum | Streptococcus | Veillonella
Pancreatic Cancer 0.0331 5 (0.01) : Akkermansia | Haemophilus | Lachnospiraceae | Lactobacillus | Megasphaera 15 (0.06) : Akkermansia | Alistipes | Anaerostipes | Anaerotruncus | Bifidobacterium | Bilophila | Blautia | Butyricicoccus | Coprococcus | Eggerthella | Flavonifractor | Mogibacterium | Parabacteroides | Porphyromonas | Ruminococcaceae
Pouchitis 0.0319 6 (0.02) : Akkermansia | Clostridium | Enterobacteriaceae | Lachnospira | Roseburia | Streptococcus 7 (0.04) : Bacteroides | Escherichia | Lachnospiraceae | Lactobacillus | Parabacteroides | Ruminococcaceae | Streptococcus
Cholestasis 0.0318 6 (0.03) : Clostridium | Enterobacteriaceae | Enterococcus | Megamonas | Megasphaera | Streptococcus 8 (0.03) : Anaerostipes | Bacteroides | Bacteroides fragilis | Bifidobacterium | Blautia | Collinsella | Faecalibacterium prausnitzii | Roseburia
Generalized anxiety disorder 0.0314 5 (0.02) : Bacteroides | Burkholderia | Enterobacteriaceae | Ruminococcus gnavus | Shigella 11 (0.04) : Bacteroides | Butyricicoccus | Coprococcus | Dialister | Eubacterium coprostanoligenes | Eubacterium rectale | Eubacterium ruminantium | Lachnospiraceae | Prevotella | Ruminococcaceae | Subdoligranulum
Asthma 0.0310 11 (0.02) : Bacteroides | Enterobacteriaceae | Haemophilus | Lactobacillus | Odoribacter | Parabacteroides | Pseudomonas | Roseburia | Rothia | Ruminococcus | Streptococcus 17 (0.04) : Bifidobacterium | Bulleidia | Butyrivibrio | Catonella | Corynebacterium | Dialister | Enterococcus | Fusobacterium | Oribacterium | Parvimonas | Peptococcus | Prevotella | Rothia | Streptococcus | Tannerella | Treponema | Veillonella
Psoriasis 0.0305 18 (0.04) : Bacillus | Bacteroides | Bacteroides vulgatus | Bifidobacterium | Collinsella | Dorea | Enterococcus | Lachnospiraceae | Lactococcus | Megasphaera | Neisseriaceae | Parabacteroides | Parasutterella excrementihominis | Pseudomonas | Ruminococcus | Ruminococcus gnavus | Streptococcus | Sutterella 12 (0.02) : Alistipes | Bacteroides | Bacteroidetes | Barnesiella | Coprococcus | Coriobacteriaceae | Lachnospiraceae | Lactobacillus | Parabacteroides | Rothia | Ruminococcaceae | Streptococcus
Acquired Immunodeficiency Syndrome 0.0291 4 (0.02) : Enterococcus | Lactobacillus | Ruminococcus | Streptococcus 8 (0.03) : Bacteriodes uniformis | Bacteroides vulgatus | Blautia | Dialister | Phascolarctobacterium faecium | Prevotella | Roseburia | Ruminiclostridium
Acute lymphoblastic leukemia 0.0291 2 (0.01) : Bacteroides | Bacteroides fragilis 9 (0.05) : Alistipes | Atopobium | Bifidobacterium | Corynebacterium | Fusicatenibacter | Peptoniphilus | Porphyromonas | Prevotella | Veillonellaceae
Rheumatoid Arthritis 0.0285 11 (0.02) : Anaerofilum | Clostridium | Collinsella | Eggerthella lenta | Haemophilus | Lactobacillus | Neisseriaceae | Prevotella copri | Rothia | Streptococcus | Veillonellaceae 15 (0.04) : Bacteroides | Bacteroides fragilis | Bifidobacterium | Collinsella | Coriobacteriaceae | Corynebacterium | Erysipelotrichaceae | Eubacterium rectale | Parvimonas | Prevotella | Roseburia | Roseburia faecis | Selenomonas | Shigella | Streptococcus
Spinal cord injury 0.0285 5 (0.03) : Akkermansia | Bacteroides | Corynebacterium | Shigella | Veillonellaceae 6 (0.03) : Dialister | Eubacterium rectale | Lactobacillus | Prevotella | Roseburia | Subdoligranulum
Schizophrenia 0.0277 17 (0.03) : Akkermansia muciniphila | Bacteroides fragilis | Bilophila | Clostridioides difficile | Clostridium | Clostridium innocuum | Clostridium symbiosum | Dorea | Enterobacteriaceae | Eubacterium siraeum | Holdemania | Lactobacillus | Megasphaera | Ruminococcus gnavus | Shigella | Streptococcus thermophiles | Veillonellaceae 10 (0.02) : Butyricicoccus | Coprococcus | Enterococcus | Erysipelotrichaceae | Eubacterium ventriosum | Fusicatenibacter | Fusobacterium | Lachnospiraceae | Roseburia faecis | Ruminococcaceae
Gestational diabetes 0.0271 9 (0.03) : Bacteroides | Collinsella | Desulfovibrio | Enterococcus | Lachnospiraceae | Parabacteroides distasonis | Rothia | Ruminococcaceae | Shigella 9 (0.02) : Dialister | Eubacterium eligens | Eubacterium xylanophilum | Ezakiella | Lactobacillus | Parabacteroides | Porphyromonas | Prevotella | Ruminococcaceae
Behcet's Disease 0.0265 6 (0.01) : Bifidobacterium | Bilophila | Eggerthella lenta | Parabacteroides | Rothia | Streptococcus 14 (0.04) : Alistipes | Alloprevotella | Anaerotruncus | Bacteroidetes | Butyrivibrio | Coprococcus | Dialister invisus | Lachnospiraceae | Prevotella | Roseburia | Selenomonas | Subdoligranulum | TM7 | Veillonella
Hashimoto's thyroiditis 0.0263 3 (0.01) : Dorea | Roseburia | Ruminococcus torques 7 (0.04) : Bacteroides | Bifidobacterium | Dialister | Lachnoclostridium | Lactobacillus | Prevotella | Veillonellaceae
Fibromyalgia 0.0260 7 (0.02) : Clostridium scindens | Dorea | Erysipelatoclostridium ramosum | Flavonifractor plautii | Parabacteroides merdae | Roseburia | Ruminococcaceae 6 (0.03) : Bacteriodes uniformis | Bacteroides | Bifidobacterium | Faecalibacterium prausnitzii | Haemophilus parainfluenzae | Lachnospiraceae
Primary sclerosing cholangitis 0.0252 7 (0.02) : Bacteroides | Clostridium | Enterococcus | Haemophilus | Lactobacillus | Parabacteroides | Streptococcus 10 (0.03) : Anaerostipes | Blautia | Coprococcus | Faecalibacterium prausnitzii | Lachnoclostridium | Lachnospiraceae | Parabacteroides | Phascolarctobacterium | Rothia | Ruminiclostridium
Myasthenia gravis 0.0250 6 (0.03) : Bacteroides | Bilophila | Desulfovibrio | Pasteurellaceae | Streptococcus | Sutterella 6 (0.02) : Butyricicoccus | Coriobacteriaceae | Faecalibacterium prausnitzii | Lactobacillus | Parvimonas | Stomatobaculum
Colon polyps 0.0248 7 (0.03) : Bacteroides fragilis | Bacteroides stercoris | Bacteroides vulgatus | Eubacterium eligens | Faecalibacterium prausnitzii | Ruminococcus gnavus | Ruminococcus torques 3 (0.02) : Fusobacterium | Lactobacillus | Peptostreptococcus
Allergy 0.0246 4 (0.02) : Clostridium | Dorea | Roseburia | Ruminococcus gnavus 5 (0.03) : Bacteroides | Coprococcus | Enterococcus | Lactobacillus | Prevotella
Neuromyelitis optica 0.0245 4 (0.01) : Bacteroides | Corynebacterium | Shigella | Streptococcus 8 (0.04) : Blautia | Coprococcus | Fusicatenibacter | Lachnospiraceae | Peptostreptococcaceae | Prevotellaceae | Romboutsia | Roseburia
Autoimmune hepatitis 0.0232 2 (0.01) : Lactobacillus | Streptococcus 7 (0.04) : Bifidobacterium | Coprococcus | Lactobacillus | Oscillospira | Parabacteroides | Ruminococcaceae | Streptococcus
Stevens-Johnson syndrome 0.0232 12 (0.05) : Akkermansia | Bacillus | Bacteroides | Bifidobacterium | Collinsella | Lactobacillus | Megamonas | Odoribacter | Pseudomonas | Roseburia | Ruminococcus | Streptococcus 0 (0.00)
Bladder cancer 0.0230 2 (0.00) : Ruminococcaceae | Shigella 10 (0.04) : Bacteroides | Bifidobacterium | Corynebacterium | Laceyella | Lactobacillus | Prevotella | Ruminiclostridium | Ruminococcaceae | Streptococcus | Veillonella
Collagenous colitis 0.0226 3 (0.02) : Bacteroides | Lachnospiraceae | Parabacteroides 5 (0.02) : Akkermansia | Alistipes | Collinsella | Coprococcus | Ruminococcaceae
Major depressive disorder 0.0224 5 (0.01) : Bacteroides | Megamonas | Parabacteroides | Roseburia | Streptococcus 9 (0.03) : Bacteroides | Bifidobacterium | Blautia | Coprococcus | Dialister | Lachnospiraceae | Lactobacillus | Phascolarctobacterium | Prevotella
Graves' orbitopathy 0.0223 1 (0.01) : Prevotella copri 7 (0.04) : Anaerostipes | Bacteroides massiliensis | Blautia | Butyricicoccus | Collinsella | Eubacterium ventriosum | Fusicatenibacter
Human end-stage renal disease 0.0223 4 (0.02) : Alistipes shahii | Eggerthella lenta | Flavonifractor plautii | Ruminococcus 6 (0.02) : Bifidobacterium | Dialister | Eubacterium rectale | Faecalibacterium prausnitzii | Peptostreptococcaceae | Roseburia
Infantile eczema 0.0221 6 (0.01) : Akkermansia | Bilophila | Desulfovibrio | Parabacteroides | Roseburia | Shigella 10 (0.03) : Anaerotruncus | Bifidobacterium | Butyricicoccus | Collinsella | Corynebacterium | Dialister | Lactobacillus | Prevotella | Streptococcus | Turicibacter
Wilson's Disease 0.0221 3 (0.02) : Bacteroides | Lachnospira | Megamonas 3 (0.02) : Phascolarctobacterium | Prevotella | Roseburia
Chronic pancreatitis 0.0220 2 (0.01) : Parabacteroides | Shigella 6 (0.03) : Butyricicoccus | Collinsella | Erysipelotrichaceae | Lachnospiraceae | Peptostreptococcaceae | Subdoligranulum
Gastric carcinoma 0.0212 10 (0.02) : Bacteroides | Bifidobacterium | Clostridium | Corynebacterium | Lachnospiraceae | Lactobacillus | Parabacteroides | Ruminococcaceae | Shigella | Streptococcus 7 (0.02) : Bacteriodes uniformis | Bacteroides | Eubacterium rectale | Lachnoclostridium | Prevotella | Roseburia | Streptococcus
Juvenile idiopathic arthritis 0.0211 6 (0.03) : Dorea | Faecalibacterium prausnitzii | Parabacteroides | Parabacteroides distasonis | Ruminococcaceae | Veillonellaceae 4 (0.01) : Blautia | Enterococcus | Peptostreptococcaceae | Turicibacter
Fibrosis 0.0205 2 (0.01) : Ruminococcus | Streptococcus 4 (0.03) : Bacteroides | Coprococcus | Faecalibacterium prausnitzii | Oscillospira
Rectal Carcinoma 0.0204 4 (0.03) : Bacteroides | Desulfovibrio | Odoribacter | Parabacteroides 3 (0.01) : Bifidobacterium | Escherichia | Lactobacillus
Severe fever with thrombocytopenia syndrome 0.0201 5 (0.03) : Enterococcus | Lactobacillus | Roseburia | Streptococcus | Sutterella 3 (0.01) : Anaerostipes | Blautia | Prevotella
Psychogenic erectile dysfunction 0.0200 0 (0.00) 5 (0.04) : Alloprevotella | Blautia | Lachnospiraceae | Prevotella | Roseburia
Attention Deficit Hyperactivity Disorder 0.0199 4 (0.01) : Bifidobacterium | Odoribacter splanchnicus | Peptostreptococcaceae | Sutterella stercoricanis 6 (0.03) : Bacteroides coprocola | Dialister | Faecalibacterium prausnitzii | Lachnoclostridium | Lachnospiraceae | Lactobacillus
Tongue cancer 0.0199 4 (0.02) : Corynebacterium | Enterococcus | Rothia | Streptococcus 7 (0.02) : Fusobacterium | Parvimonas | Peptoniphilus | Peptostreptococcus | Porphyromonas | Prevotella | Treponema
Thyroid carcinoma 0.0196 6 (0.01) : Lactobacillus | Lactococcus | Roseburia | Ruminococcus | Shigella | Streptococcus 7 (0.02) : Alloprevotella | Bacteroides | Butyricimonas | Lachnoclostridium | Phascolarctobacterium | Prevotella | Roseburia
Arsenic exposure 0.0193 3 (0.02) : Enterococcus | Ruminococcus | Streptococcus 4 (0.02) : Bacteroides | Bifidobacterium | Coprococcus | Parabacteroides
Polycystic ovary syndrome 0.0191 3 (0.01) : Bacteroides vulgatus | Eubacterium eligens | Lactobacillus 7 (0.03) : Akkermansia | Alloprevotella | Bacteroides | Lactobacillus | Parabacteroides | Prevotella | Ruminococcaceae
Idiopathic focal epilepsy 0.0189 1 (0.00) : Haemophilus 6 (0.04) : Bacteroides | Bifidobacterium | Blautia | Collinsella | Coprococcus | Parabacteroides
Reactive arthritis 0.0183 1 (0.00) : Pseudomonas 4 (0.03) : Blautia | Collinsella | Coprococcus | Roseburia
Ischemic stroke 0.0183 3 (0.01) : Akkermansia | Enterobacteriaceae | Enterococcus 5 (0.02) : Anaerostipes | Bacteroides | Blautia | Lachnospiraceae | Roseburia
Chronic Obstructive Pulmonary Disease 0.0182 11 (0.02) : Bifidobacterium | Burkholderia | Clostridium symbiosum | Corynebacterium | Haemophilus | Kingella | Klebsiella pneumoniae | Lactobacillus | Pseudomonas | Rothia | Streptococcus 9 (0.02) : Actinomyces | Bacteroidetes | Corynebacterium | Haemophilus parainfluenzae | Oribacterium | Prevotella | Selenomonas | Streptococcus | Veillonella
Atopic wheeze 0.0181 3 (0.02) : Clostridioides difficile | Ruminococcus gnavus | Streptococcus 2 (0.02) : Bacteroides | Bifidobacterium
Colon adenomas 0.0180 6 (0.02) : Dorea | Lactococcus | Megamonas | Pseudomonas | Ruminococcus | Shigella 6 (0.02) : Bacteroides | Butyricicoccus | Butyricimonas | Collinsella | Coprococcus | Lachnoclostridium
Systemic lupus erythematosus 0.0173 11 (0.02) : Bacteroides vulgatus | Blautia faecis | Corynebacterium | Lachnospiraceae | Lactobacillus | Megasphaera | Prevotella oulorum | Pseudomonas | Rothia | Ruminococcus gnavus | Veillonellaceae 7 (0.01) : Alistipes onderdonkii | Bifidobacterium | Faecalibacterium prausnitzii | Haemophilus parainfluenzae | Peptostreptococcaceae | Prevotella | Roseburia
Microscopic colitis 0.0173 2 (0.00) : Desulfovibrio | Lachnospiraceae 8 (0.03) : Akkermansia | Anaerotruncus | Coprococcus | Coriobacteriaceae | Prevotella | Romboutsia | Ruminiclostridium | Subdoligranulum
Cardiac valve calcification 0.0173 2 (0.01) : Enterococcus | Lactobacillus 5 (0.03) : Bacteroides | Blautia | Clostridiaceae | Erysipelotrichaceae | Ruminococcaceae
Urogenital Schistosomiasis 0.0173 7 (0.03) : Aerococcus | Bacteroides | Desulfovibrio | Enterococcus | Haemophilus | Lactobacillus | Megasphaera 4 (0.01) : Erysipelotrichaceae | Parabacteroides | Ruminococcaceae | Subdoligranulum
Chronic urticaria 0.0173 1 (0.01) : Enterobacteriaceae 4 (0.03) : Bacteroides | Bifidobacterium | Lactobacillus | Ruminococcaceae
Smoking 0.0172 7 (0.01) : Bacteroides | Bifidobacterium | Corynebacterium | Lactobacillus | Lactococcus | Rothia | Streptococcus 11 (0.02) : Actinomyces | Corynebacterium | Lactobacillus | Lautropia mirabilis | Peptococcus | Peptostreptococcus | Porphyromonas | Prevotella | Selenomonas | Streptococcus | Veillonella
Silicosis 0.0172 3 (0.02) : Lachnospiraceae | Megamonas | Parabacteroides 5 (0.02) : Bacteroides | Bifidobacterium | Blautia | Shigella | Subdoligranulum
Biliary atresia 0.0172 3 (0.02) : Enterococcus | Lactobacillus | Streptococcus 4 (0.01) : Anaerostipes | Bacteroides | Bifidobacterium | Blautia
COPD Exacerbation 0.0170 1 (0.00) : Haemophilus 7 (0.03) : Actinomyces | Lachnospiraceae | Prevotella | Ruminococcaceae | Streptococcus | Subdoligranulum | Treponema
Caries 0.0169 9 (0.01) : Haemophilus | Lachnospiraceae | Lactobacillus | Megasphaera | Mitsuokella | Peptostreptococcaceae | Pseudomonas | Streptococcus | Veillonellaceae 15 (0.03) : Actinomyces | Alloprevotella | Bacteroidetes | Corynebacterium | Fusobacterium | Haemophilus parainfluenzae | Lachnospiraceae | Lautropia mirabilis | Peptococcus | Porphyromonas | Prevotella | Selenomonas | Shigella | Stomatobaculum | Streptococcus
Pancreatitis 0.0166 5 (0.01) : Bacteroides | Enterobacteriaceae | Enterococcus | Parabacteroides | Shigella 6 (0.02) : Bifidobacterium | Blautia | Corynebacterium | Faecalibacterium prausnitzii | Lachnospiraceae | Prevotella
Gingivitis 0.0165 1 (0.01) : Streptococcus 3 (0.02) : Prevotella | Streptococcus | Veillonella
Amyotrophic lateral sclerosis 0.0158 8 (0.03) : Akkermansia muciniphila | Bacteroides vulgatus | Lachnospiraceae | Odoribacter | Parabacteroides | Parabacteroides distasonis | Ruminococcus | Ruminococcus torques 1 (0.00) : Bacteroides
Graves' disease 0.0156 2 (0.01) : Haemophilus | Pasteurellaceae 5 (0.02) : Alistipes | Bifidobacterium | Lactobacillus | Parabacteroides | Veillonellaceae
Atherosclerosis 0.0153 5 (0.01) : Collinsella | Eggerthella lenta | Enterobacteriaceae | Ruminococcus gnavus | Streptococcus 5 (0.02) : Bacteroides | Eubacterium eligens | Faecalibacterium prausnitzii | Roseburia | Roseburia intestinalis
Head/Neck cancer 0.0153 1 (0.00) : Ruminococcus 6 (0.03) : Actinomyces | Fusobacterium | Haemophilus parainfluenzae | Lachnospiraceae | Selenomonas | Tannerella
Metabolic syndrome 0.0153 1 (0.00) : Akkermansia muciniphila 6 (0.03) : Bifidobacterium | Eubacterium eligens | Faecalibacterium prausnitzii | Roseburia intestinalis | Subdoligranulum | Turicibacter
Iron-deficiency anaemia 0.0152 4 (0.03) : Enterococcus | Lactobacillus | Lactococcus | Pseudomonas 1 (0.00) : Corynebacterium
Spondyloarthritis 0.0150 4 (0.02) : Bifidobacterium | Dorea | Lachnospiraceae | Ruminococcus gnavus 3 (0.01) : Faecalibacterium prausnitzii | Lachnospiraceae | Roseburia
Aggressive periodontitis 0.0150 2 (0.00) : Cardiobacterium | Peptostreptococcaceae 14 (0.03) : Akkermansia | Bacteroides | Bifidobacterium | Clostridiaceae | Corynebacterium | Escherichia coli | Haemophilus parainfluenzae | Lachnospiraceae | Lautropia mirabilis | Oribacterium | Oscillospira | Prevotella | Streptococcus | Veillonella
Atrophic gastritis 0.0150 3 (0.03) : Bacteroides | Enterobacteriaceae | Parabacteroides 2 (0.00) : Lachnospiraceae | Roseburia
Interstitial cystitis 0.0143 3 (0.01) : Bacteroides | Bifidobacterium | Enterococcus 7 (0.02) : Coprococcus | Dialister | Eggerthella | Lactobacillus | Peptostreptococcus | Prevotella | Streptococcus
Osteoporosis 0.0142 5 (0.02) : Bacteroides | Lactobacillus | Lactobacillus reuteri | Parabacteroides | Ruminococcaceae 1 (0.01) : Roseburia
Frailty 0.0140 2 (0.01) : Dorea | Eggerthella lenta 2 (0.02) : Faecalibacterium prausnitzii | Lachnospiraceae
Acne 0.0138 7 (0.02) : Bacteroides | Corynebacterium | Enterobacteriaceae | Enterococcus | Odoribacter | Oscillospira | Ruminococcus 6 (0.01) : Bifidobacterium | Bilophila | Blautia | Butyricicoccus | Fusicatenibacter | Lactobacillus
Endometriosis 0.0136 6 (0.01) : Aerococcus | Corynebacterium | Enterobacteriaceae | Pseudomonas | Shigella | Streptococcus 4 (0.02) : Atopobium | Barnesiella | Dialister | Prevotella
Infective colitis 0.0135 1 (0.01) : Bacteroides 3 (0.02) : Bifidobacterium | Clostridium leptum | Faecalibacterium prausnitzii
Prediabetes 0.0135 3 (0.03) : Dorea | Streptococcus | Sutterella 0 (0.00)
Hand, foot and mouth disease 0.0133 3 (0.02) : Bifidobacterium | Enterococcus | Streptococcus 2 (0.01) : Phascolarctobacterium | Roseburia
Urolithiasis 0.0130 2 (0.02) : Enterobacteriaceae | Lachnospiraceae 1 (0.01) : Lactobacillus
Wiskott-Aldrich syndrome 0.0129 1 (0.00) : Shigella 4 (0.02) : Alistipes | Bacteroides | Parabacteroides | Phascolarctobacterium
Constipation 0.0126 2 (0.00) : Enterococcus | Ruminococcus 5 (0.02) : Adlercreutzia | Blautia | Fusicatenibacter | Odoribacter | Prevotella
Cavernous angioma 0.0125 1 (0.01) : Odoribacter splanchnicus 2 (0.02) : Bifidobacterium adolescentis | Faecalibacterium prausnitzii
Hyperthyroidism 0.0125 1 (0.01) : Enterococcus 2 (0.02) : Bifidobacterium | Lactobacillus
Chronic stress 0.0121 3 (0.02) : Bacteroides | Parabacteroides | Roseburia 1 (0.01) : Phascolarctobacterium
Liver transplant 0.0120 0 (0.00) 3 (0.02) : Bifidobacterium | Faecalibacterium prausnitzii | Lactobacillus
Influenza A 0.0118 4 (0.01) : Acidobacteria | Lactobacillus | Pseudomonas | Streptococcus 4 (0.01) : Corynebacterium | Fusobacterium | Rothia | Streptococcus
Tetratricopeptide repeat domain 7A deficiency 0.0116 2 (0.01) : Clostridium | Enterobacteriaceae 2 (0.02) : Oscillospira | Ruminococcaceae
Heart failure 0.0112 3 (0.01) : Enterococcus | Lactobacillus | Streptococcus 5 (0.01) : Bilophila | Butyricicoccus | Collinsella | Eubacterium rectale | Faecalibacterium prausnitzii
Kawasaki disease 0.0112 5 (0.02) : Clostridium | Megamonas | Roseburia | Roseburia intestinalis | Ruminococcus 1 (0.00) : Rothia
Alcoholic cirrhosis 0.0111 1 (0.00) : Streptococcus thermophiles 4 (0.02) : Alistipes | Dialister | Parvimonas | Prevotella
Eosinophilic esophagitis 0.0108 2 (0.01) : Corynebacterium | Haemophilus 3 (0.01) : Actinomyces | Lactobacillus | Streptococcus
Chronic prostatitis - Chronic pelvic pain syndrome 0.0107 0 (0.00) 4 (0.02) : Coriobacteriaceae | Mogibacterium | Porphyromonas | Prevotella
Anorexia nervosa 0.0104 3 (0.02) : Akkermansia muciniphila | Enterobacteriaceae | Enterococcus 2 (0.00) : Roseburia | Streptococcus
Chronic fatigue syndrome 0.0103 3 (0.01) : Enterobacteriaceae | Enterococcus | Streptococcus 5 (0.01) : Bacteroides | Bacteroidetes | Bifidobacterium | Ruminococcaceae | Turicibacter
Diarrhea 0.0103 1 (0.00) : Bacteroides 2 (0.02) : Bifidobacterium | Enterococcus
Anti-N-methyl-D-aspartate receptor encephalitis 0.0101 3 (0.02) : Bacteroides | Parabacteroides | Streptococcus 0 (0.00)
Pressure ulcers 0.0101 6 (0.02) : Bacteroides | Dorea | Enterococcus | Lactococcus | Parabacteroides distasonis | Ruminococcus gnavus 0 (0.00)
Chagas' disease 0.0099 4 (0.01) : Enterococcus | Lactobacillus | Roseburia | Streptococcus 2 (0.01) : Actinomyces | Bacteroides
Bipolar disorder 0.0098 2 (0.00) : Bacteroides | Parabacteroides 4 (0.02) : Bacteroidetes | Coprococcus | Roseburia | Ruminococcaceae
Multiple system atrophy 0.0098 4 (0.01) : Akkermansia muciniphila | Bacteroides | Bacteroides fragilis | Lactobacillus 3 (0.01) : Bacteroides coprocola | Blautia | Tyzzerella nexilis
Depression 0.0096 1 (0.00) : Lactobacillus 3 (0.02) : Bacteroides fragilis | Coprococcus | Dialister
Chronic Rhinosinusitis 0.0096 1 (0.00) : Pseudomonas 7 (0.02) : Bacteroides | Bacteroidetes | Lachnospiraceae | Lactobacillus | Parabacteroides | Peptoniphilus | Ruminococcaceae
Pregnancy 0.0096 1 (0.00) : Streptococcus 7 (0.02) : Dialister | Eggerthella | Peptoniphilus | Prevotella | Ruminococcaceae | Streptococcus | Veillonella
Adolescent idiopathic scoliosis 0.0096 2 (0.01) : Barnesiella | Desulfovibrio 3 (0.01) : Bacteroides fragilis | Phascolarctobacterium | Tyzzerella
Hepatic encephalopathy 0.0095 5 (0.01) : Bifidobacterium | Burkholderia | Enterobacteriaceae | Enterococcus | Megasphaera 3 (0.01) : Lachnospiraceae | Prevotellaceae | Roseburia
Radiation enteritis 0.0095 1 (0.00) : Megamonas 2 (0.02) : Bacteroides | Blautia
Chronic Laryngitis 0.0094 2 (0.02) : Pseudomonas | Streptococcus 1 (0.00) : Prevotella
Conjunctival scarring 0.0090 2 (0.02) : Corynebacterium | Streptococcus 0 (0.00)
Aphthous stomatitis 0.0090 0 (0.00) 3 (0.02) : Akkermansia | Streptococcaceae | Veillonellaceae
Liver fibrosis 0.0090 0 (0.00) 3 (0.02) : Coriobacteriaceae | Lachnospiraceae | Ruminococcaceae
Autoimmune Thyroid Disorders 0.0090 0 (0.00) 3 (0.02) : Bifidobacterium | Faecalibacterium prausnitzii | Lactobacillus
Cutaneous burn 0.0086 1 (0.00) : Enterococcus 2 (0.02) : Lactobacillus | Streptococcus
Preeclamsia 0.0085 6 (0.01) : Bacillus | Bilophila | Clostridium | Enterobacteriaceae | Klebsiella pneumoniae | Ruminococcus 2 (0.00) : Akkermansia | Dialister
Oral lichen planus 0.0083 1 (0.00) : Candida 6 (0.02) : Bacteroides | Ezakiella | Haemophilus parainfluenzae | Rothia | Streptococcus | Streptococcus salivarius
Hirschsprung's disease 0.0083 2 (0.01) : Bacillus | Pseudomonas 2 (0.01) : Lachnospiraceae | Ruminococcaceae
Overactive bladder 0.0083 1 (0.00) : Aerococcus 5 (0.02) : Dialister | Enterococcus | Fusobacterium | Lactobacillus | Prevotella
Breast cancer 0.0082 3 (0.00) : Bacillus | Corynebacterium | Enterobacteriaceae 5 (0.01) : Corynebacterium | Escherichia coli | Prevotella | Streptococcus | Veillonella
Postmenopausal 0.0080 1 (0.00) : Bacteroides 3 (0.01) : Alistipes | Lactobacillus | Roseburia
Diverticular disease 0.0080 2 (0.01) : Enterobacteriaceae | Ruminococcaceae 1 (0.00) : Bacteroides fragilis
Posttreatment Lyme disease syndrome 0.0080 0 (0.00) 2 (0.02) : Bacteroides | Roseburia
Transient Ischemic Attack 0.0078 4 (0.01) : Desulfovibrio | Lactobacillus | Megasphaera | Parabacteroides 2 (0.01) : Bacteroides | Prevotella
Hepatitis C 0.0078 4 (0.01) : Akkermansia | Haemophilus | Lactobacillus | Streptococcus 3 (0.01) : Bilophila | Butyricimonas | Parabacteroides
T2D with hypertension 0.0078 2 (0.01) : Roseburia | Ruminococcus 2 (0.00) : Lactobacillus | Parvimonas
Clonorchis sinensis infection 0.0078 2 (0.00) : Dorea | Ruminococcus 3 (0.01) : Bacteroides | Parabacteroides | Veillonella
Pulmonary arterial hypertension 0.0078 3 (0.01) : Parabacteroides merdae | Roseburia inulinivorans | Ruminococcus gnavus 2 (0.00) : Bacteroides coprocola | Subdoligranulum
Acute fatty liver 0.0078 1 (0.00) : Enterococcus 3 (0.01) : Adlercreutzia | Blautia | Fusicatenibacter
Excessive vomiting 0.0078 1 (0.00) : Enterococcus 3 (0.01) : Adlercreutzia | Blautia | Fusicatenibacter
Cirrhosis with pneumonia 0.0076 2 (0.01) : Bacteroides | Lachnospiraceae 1 (0.01) : Streptococcus
Budd-Chiari syndrome 0.0076 1 (0.00) : Megasphaera 2 (0.01) : Escherichia | Peptostreptococcaceae
Rett Syndrome 0.0075 1 (0.00) : Bifidobacterium 3 (0.01) : Alistipes | Bacteroides | Streptococcus
Oral cancer 0.0073 6 (0.01) : Clostridium | Enterobacteriaceae | Haemophilus | Lactobacillus | Rothia | Streptococcus 5 (0.01) : Oribacterium | Rothia | Streptococcus | Streptococcus salivarius | TM7
Vulvar vestibulitis syndrome 0.0073 2 (0.01) : Enterococcus | Streptococcus 1 (0.00) : Atopobium
Sickle cell disease 0.0072 0 (0.00) 3 (0.01) : Alistipes | Prevotella | Subdoligranulum
Coronary Heart Disease 0.0071 0 (0.00) 4 (0.01) : Bacteroidetes | Collinsella | Parabacteroides | Prevotella
Dry eye syndrom 0.0070 2 (0.00) : Megasphaera | Parabacteroides 2 (0.01) : Subdoligranulum | Veillonella
Protracted bacterial bronchitis 0.0067 5 (0.01) : Bacillus | Bifidobacterium | Enterococcus | Haemophilus | Pseudomonas 1 (0.00) : Lactobacillus
Periodontal disease 0.0066 2 (0.00) : Peptostreptococcaceae | Veillonellaceae 6 (0.01) : Actinomyces | Atopobium | Corynebacterium | Haemophilus parainfluenzae | Lautropia mirabilis | Streptococcus
Obstructive sleep apnea-hypopnea syndrome 0.0066 3 (0.01) : Haemophilus | Pseudomonas | Streptococcus 5 (0.01) : Bifidobacterium | Clostridiaceae | Dialister | Fusicatenibacter | Ruminococcaceae
Invasive colorectal cancer 0.0066 2 (0.01) : Corynebacterium | Enterococcus 2 (0.01) : Lactobacillus | Oribacterium
Autoimmune polyendocrine syndrome type 1 0.0065 0 (0.00) 7 (0.01) : Bacteroides | Bacteroidetes | Catonella | Haemophilus parainfluenzae | Lachnospiraceae | Peptostreptococcaceae | Ruminococcaceae
Primary liver cancer 0.0065 3 (0.01) : Enterococcus | Ruminococcus gnavus | Shigella 1 (0.00) : Prevotellaceae
Neuro-Behcet's disease 0.0065 1 (0.01) : Parabacteroides 1 (0.00) : Lachnospiraceae
Macular degeneration 0.0064 3 (0.00) : Rothia | Ruminococcus torques | Streptococcus 2 (0.01) : Fusobacterium | Prevotella
Periodontal abscess 0.0064 0 (0.00) 4 (0.01) : Lachnoanaerobaculum | Prevotella | Selenomonas | Veillonella
Diabetic nephropathy 0.0063 1 (0.00) : Shigella 1 (0.01) : Prevotella
Fatigue 0.0063 1 (0.00) : Ruminococcus gnavus 2 (0.01) : Alistipes | Faecalibacterium prausnitzii
Bleeding gum 0.0060 0 (0.00) 3 (0.01) : Actinomyces | Streptococcus | Veillonella
Halitosis 0.0058 0 (0.00) 4 (0.01) : Haemophilus parainfluenzae | Oribacterium | Streptococcus | Streptococcus salivarius
Anovulation 0.0058 0 (0.00) 4 (0.01) : Anaerostipes | Lachnospiraceae | Oscillospira | Roseburia
Extrinsic black dental staining 0.0057 3 (0.01) : Cardiobacterium | Corynebacterium | Haemophilus 1 (0.00) : TM7
Keratitis 0.0056 2 (0.01) : Bacteroides fragilis | Dorea 4 (0.01) : Bifidobacterium adolescentis | Dialister | Faecalibacterium prausnitzii | Roseburia
Diaper dermatitis 0.0056 1 (0.00) : Ruminococcus gnavus 3 (0.01) : Bifidobacterium longum | Clostridium butyricum | Clostridium perfringens
Seminal hyperviscosity 0.0055 1 (0.00) : Pseudomonas 1 (0.01) : Lactobacillus
Oligoasthenoteratozoospermia 0.0055 1 (0.00) : Pseudomonas 1 (0.01) : Lactobacillus
Hemodialysis with Normal Weight Obesity 0.0055 1 (0.00) : Lachnobacterium 2 (0.01) : Coprococcus | Faecalibacterium prausnitzii
Vaginal Chlamydiosis 0.0054 6 (0.01) : Collinsella | Corynebacterium | Lactobacillus | Megasphaera | Pseudomonas | Streptococcus 0 (0.00)
Chronic mucocutaneous candidiasis 0.0053 0 (0.00) 2 (0.01) : Corynebacterium | Prevotella
Hyper IgE syndrome 0.0053 0 (0.00) 2 (0.01) : Corynebacterium | Prevotella
Posttraumatic stress syndrome 0.0053 1 (0.00) : Streptococcus 3 (0.01) : Anaerostipes | Roseburia | Subdoligranulum
Severe congenital neutropenia 0.0053 0 (0.00) 2 (0.01) : Alloprevotella | Fusobacterium
Chronic Rhinosinusitis with cystic fibrosis 0.0051 1 (0.00) : Streptococcus 1 (0.01) : Corynebacterium
H7N9 0.0051 3 (0.01) : Bacteroides | Megasphaera | Pseudomonas 0 (0.00)
Idiopathic central precocious puberty 0.0051 4 (0.01) : Barnesiella | Holdemania | Pseudomonas | Roseburia inulinivorans 0 (0.00)
Prostate cancer 0.0048 1 (0.00) : Akkermansia muciniphila 1 (0.01) : Corynebacterium
Mucosa-associated lymphoid tissue lymphoma 0.0048 2 (0.00) : Clostridium | Rothia 3 (0.01) : Bacteroides | Lactobacillus | Parabacteroides
Kidney stone with hypertension 0.0048 1 (0.00) : Lactobacillus 5 (0.01) : Bilophila | Butyricicoccus | Butyrivibrio | Phascolarctobacterium | Selenomonas
Pemphigus vulgaris 0.0047 1 (0.00) : Collinsella 2 (0.01) : Flavonifractor | Shigella
Primary Open-Angle Glaucoma 0.0045 2 (0.01) : Enterobacteriaceae | Streptococcus 0 (0.00)
Cleft palate 0.0045 1 (0.01) : Streptococcus 0 (0.00)
Edentulism 0.0045 2 (0.00) : Klebsiella pneumoniae | Megasphaera 5 (0.01) : Dialister invisus | Lautropia mirabilis | Peptococcus | Peptostreptococcaceae | TM7
Intrahepatic Cholangiocarcinoma 0.0045 2 (0.01) : Lactobacillus | Peptostreptococcaceae 0 (0.00)
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy 0.0045 2 (0.01) : Lachnospira | Odoribacter 0 (0.00)
Stomach cancer 0.0043 1 (0.00) : Ruminococcus 1 (0.00) : Lachnoclostridium
Common Variable Immunodeficieny 0.0043 2 (0.01) : Enterobacteriaceae | Streptococcus 1 (0.00) : Coriobacteriaceae
Exacerbations of idiopathic pulmonary fibrosis 0.0040 0 (0.00) 1 (0.01) : Veillonella
Chronic rhinosinusitis with nasal polyps 0.0040 0 (0.00) 2 (0.01) : Bifidobacterium longum | Corynebacterium
Viral respiratory tract infection 0.0040 0 (0.00) 1 (0.01) : Prevotella
Maturity-onset diabetes of the young 2 0.0040 0 (0.00) 2 (0.01) : Anaerostipes | Roseburia
Infant colic 0.0040 0 (0.00) 1 (0.01) : Bifidobacterium
Undernourishment 0.0040 0 (0.00) 1 (0.01) : Bacteroidetes
Laryngotracheal stenosis 0.0040 0 (0.00) 1 (0.01) : Prevotella
Meningococcal disease 0.0040 0 (0.00) 1 (0.01) : Veillonella
Nasolacrimal duct obstruction 0.0040 0 (0.00) 1 (0.01) : Corynebacterium
Idiopathic Pulmonary Fibrosis 0.0039 3 (0.01) : Haemophilus | Rothia | Streptococcus 1 (0.00) : Coprococcus
Esophageal cancer 0.0036 2 (0.01) : Akkermansia muciniphila | Enterobacteriaceae 0 (0.00)
Recurrent tonsillitis 0.0036 0 (0.00) 4 (0.01) : Haemophilus parainfluenzae | Oribacterium | Selenomonas | Streptococcus salivarius
Otitis Media 0.0036 2 (0.00) : Haemophilus | Streptococcus 3 (0.01) : Corynebacterium | Rothia | Streptococcus
Gestational diabetes + hyperlipidemia 0.0036 2 (0.01) : Haemophilus | Streptococcus 0 (0.00)
Allergic asthma 0.0035 1 (0.00) : Bifidobacterium 1 (0.00) : Faecalibacterium prausnitzii
Recurrent miscarriage 0.0035 1 (0.00) : Streptococcus 1 (0.00) : Lactobacillus
Laryngeal carcinoma 0.0034 1 (0.00) : Burkholderia 2 (0.01) : Rothia | Streptococcus
Systemic sclerosis 0.0034 3 (0.01) : Bifidobacterium | Burkholderia | Lactobacillus 0 (0.00)
Bacterial vaginosis 0.0034 6 (0.01) : Aerococcus | Allisonella | Lachnospira | Lachnospiraceae | Megasphaera | Streptococcus 1 (0.00) : Lactobacillus
Primary biliary cirrhosis 0.0034 3 (0.01) : Enterobacteriaceae | Neisseriaceae | Streptococcus 0 (0.00)
Cervical cancer 0.0032 3 (0.01) : Dorea | Roseburia | Ruminococcus 1 (0.00) : Phascolarctobacterium
Bronchiectasis 0.0031 1 (0.00) : Pseudomonas 1 (0.00) : Rothia
Chronic ocular graft-versus-host disease 0.0031 1 (0.00) : Corynebacterium 1 (0.00) : Enterobacter cloacae
Melanoma 0.0030 2 (0.01) : Bifidobacterium | Ruminococcaceae 0 (0.00)
Aphthous ulcer 0.0030 2 (0.00) : Lactobacillus | Shigella 2 (0.00) : Streptococcus | Veillonella
Preterm birth 0.0029 2 (0.00) : Rothia | Streptococcus 2 (0.00) : Bacteroides | Bifidobacterium longum
Uveitits 0.0029 2 (0.00) : Burkholderia | Streptococcus 4 (0.00) : Bacteroides | Blautia | Odoribacter | Roseburia
Invasive pneumococcal disease 0.0029 3 (0.01) : Megasphaera | Rothia | Streptococcus 0 (0.00)
Genitourinary lichen sclerosus 0.0028 1 (0.00) : Lactobacillus 1 (0.00) : Dialister
Vitiligo 0.0027 0 (0.00) 2 (0.01) : Corynebacterium | Turicibacter
Functional dyspepsia 0.0026 2 (0.01) : Bacteroides | Shigella 0 (0.00)
Granulomatosis with polyangiitis 0.0026 2 (0.01) : Corynebacterium | Pasteurellaceae 0 (0.00)
Alopecia universalis 0.0026 2 (0.01) : Lachnospiraceae | Parabacteroides distasonis 0 (0.00)
Aerobic vaginitis 0.0025 5 (0.00) : Enterococcus | Faecalibacterium prausnitzii | Haemophilus | Klebsiella pneumoniae | Streptococcus 1 (0.00) : Lactobacillus
Kaposi's sarcoma 0.0025 1 (0.00) : Corynebacterium 1 (0.00) : Porphyromonas
Botulism 0.0023 1 (0.00) : Enterobacteriaceae 0 (0.00)
Intestinal metaplasia 0.0023 2 (0.00) : Lactococcus | Streptococcus 0 (0.00)
Acute cerbral infarction 0.0023 1 (0.00) : Prevotella copri 0 (0.00)
Traumatic Brain Injury 0.0023 1 (0.00) : Desulfovibrio 0 (0.00)
Pancreatic head cancer 0.0021 2 (0.00) : Corynebacterium | Rothia 1 (0.00) : Porphyromonas
Gout 0.0020 0 (0.00) 1 (0.00) : Faecalibacterium prausnitzii
Shiga Toxin-producing E. coli infection 0.0020 0 (0.00) 1 (0.00) : Bifidobacterium longum
Urgency urinary incontinence 0.0020 0 (0.00) 1 (0.00) : Lactobacillus
Sicca syndrome 0.0020 3 (0.00) : Megasphaera | Mitsuokella | Ruminococcaceae 1 (0.00) : Streptococcus
Neisseria gonorrhoeae infection 0.0020 0 (0.00) 1 (0.00) : Escherichia
Necrotizing enterocolitis 0.0018 2 (0.00) : Enterococcus | Klebsiella pneumoniae 0 (0.00)
Trachoma 0.0015 1 (0.00) : Corynebacterium 0 (0.00)
Pneumonia 0.0015 1 (0.00) : Rothia 1 (0.00) : Streptococcus
Cervical intraneoplasia 0.0015 1 (0.00) : Lactobacillus 0 (0.00)
Hepatitis B associated liver failure 0.0014 1 (0.00) : Burkholderia 1 (0.00) : Bacteroides fragilis
Osmotic diarrhea 0.0013 0 (0.00) 1 (0.00) : Alistipes
Biliary tract cancer 0.0013 0 (0.00) 1 (0.00) : Corynebacterium
Blepharitis 0.0011 1 (0.00) : Corynebacterium 0 (0.00)
Bullous pemphigoid 0.0011 1 (0.00) : Corynebacterium 0 (0.00)
Oropharyngeal cancer 0.0011 1 (0.00) : Prevotella copri 0 (0.00)
Hypopharyngeal cancer 0.0011 1 (0.00) : Prevotella copri 0 (0.00)

[Overlap Factors (Causality ?)]

FactorOverlapCommon increased OrganismCommon decreased Organism
Oral administration of Metformin 0.0177 5 (0.03) : Akkermansia muciniphila | Lactococcus | Megasphaera | Ruminococcaceae | Ruminococcus 3 (0.01) : Coriobacteriaceae | Lactobacillus | Roseburia
Heat Stress 0.0170 2 (0.02) : Clostridium | Oscillospira 2 (0.02) : Bacteroides | Lactobacillus
Exposure to Glyphosate 0.0168 1 (0.00) : Parabacteroides 4 (0.03) : Butyricicoccus | Lactobacillus | Rothia | Streptococcus
High Water drinking 0.0165 1 (0.01) : Dorea 3 (0.02) : Bacteroides | Odoribacter | Peptostreptococcus
Mediterranean diet 0.0135 3 (0.03) : Faecalibacterium prausnitzii | Lachnospiraceae | Roseburia 0 (0.00)
Sugar intake 0.0130 2 (0.02) : Akkermansia muciniphila | Bacteroides fragilis 1 (0.01) : Lactobacillus
High salt diet 0.0130 2 (0.02) : Akkermansia | Bifidobacterium 1 (0.01) : Lactobacillus
Grape powder consumption 0.0125 2 (0.01) : Akkermansia | Lachnospiracea 2 (0.02) : Bifidobacterium | Dialister
Protein powder consumption 0.0111 0 (0.00) 5 (0.02) : Bifidobacterium longum | Blautia | Coprococcus | Lachnospiraceae | Roseburia
Consumption of Coffee 0.0100 4 (0.02) : Bifidobacterium | Lachnospiracea | Odoribacter | Roseburia 1 (0.00) : Erysipelatoclostridium
Low FODMAP diet 0.0085 1 (0.01) : Bacteroides 1 (0.01) : Bifidobacterium
Maternal Antibiotic Exposure 0.0080 0 (0.00) 2 (0.02) : Bacteroidetes | Bifidobacterium
Curcumin Supplementation 0.0080 0 (0.00) 2 (0.02) : Escherichia | Shigella
High Socio-economic status 0.0051 1 (0.00) : Lachnospiraceae 1 (0.01) : Bacteroides
High-fat diet 0.0045 0 (0.00) 3 (0.01) : Akkermansia | Bacteroidetes | Ruminococcaceae
Oral administration of Abiraterone acetate 0.0045 1 (0.01) : Akkermansia muciniphila 0 (0.00)
Alcohol administration 0.0040 0 (0.00) 1 (0.01) : Akkermansia
Eating appel 0.0023 1 (0.00) : Akkermansia 0 (0.00)
Aging 0.0020 0 (0.00) 1 (0.00) : Bifidobacterium
Antibiotic Therapy 0.0015 1 (0.00) : Enterobacteriaceae 0 (0.00)
Cannabis smoking 0.0015 1 (0.00) : Streptococcus 0 (0.00)
Milk Formula-feeding 0.0011 1 (0.00) : Bacteroides 0 (0.00)

[Reverse Overlap Factors (Curability ?)]

FactorOverlapIncrease decreased Org/DisDecrease increased Org/Dis
Exposure to Glyphosate 0.0360 6 (0.05) : Actinomyces | Fusobacterium | Parabacteroides | Prevotella | Turicibacter | Veillonella 3 (0.02) : Lactobacillus | Rothia | Streptococcus
Consumption of Coffee 0.0200 6 (0.04) : Alistipes | Bifidobacterium | Blautia | Dialister | Odoribacter | Roseburia 1 (0.00) : Lachnospiracea
Mediterranean diet 0.0188 3 (0.03) : Faecalibacterium prausnitzii | Lachnospiraceae | Roseburia 2 (0.01) : Ruminococcus gnavus | Ruminococcus torques
Oral administration of Metformin 0.0136 3 (0.01) : Bacteroidetes | Butyrivibrio | Ruminococcaceae 4 (0.02) : Dorea | Lactobacillus | Roseburia | Sutterella
High salt diet 0.0130 2 (0.02) : Akkermansia | Bifidobacterium 1 (0.01) : Lactobacillus
Heat Stress 0.0103 1 (0.00) : Oscillospira 2 (0.02) : Bacteroides | Lactobacillus
Eating appel 0.0090 2 (0.02) : Akkermansia | Bacteroidetes 0 (0.00)
Low FODMAP diet 0.0085 1 (0.01) : Bacteroides 1 (0.01) : Bifidobacterium
High Socio-economic status 0.0085 2 (0.01) : Anaerostipes | Lachnospiraceae 1 (0.01) : Bacteroides
Grape powder consumption 0.0065 2 (0.01) : Akkermansia | Flavonifractor 1 (0.00) : Bifidobacterium
Sugar intake 0.0063 1 (0.00) : Bacteroides fragilis 1 (0.01) : Lactobacillus
Protein powder consumption 0.0063 1 (0.01) : Bacteroidetes 2 (0.00) : Lachnospiraceae | Roseburia
Cannabis smoking 0.0060 2 (0.01) : Actinomyces | Streptococcus 0 (0.00)
High Water drinking 0.0053 0 (0.00) 2 (0.01) : Bacteroides | Odoribacter
Curcumin Supplementation 0.0043 1 (0.00) : Lachnoclostridium 1 (0.00) : Shigella
Probiotic (Bifidobacter and Lactobacilus) 0.0040 0 (0.00) 1 (0.01) : Enterobacteriaceae
Alcohol administration 0.0040 0 (0.00) 1 (0.01) : Akkermansia
Aging 0.0020 0 (0.00) 1 (0.00) : Bifidobacterium
High-fat diet 0.0020 0 (0.00) 2 (0.00) : Akkermansia | Ruminococcaceae
Maternal Antibiotic Exposure 0.0020 0 (0.00) 1 (0.00) : Bifidobacterium
Milk Formula-feeding 0.0011 1 (0.00) : Bacteroides 0 (0.00)

Common References