MetaBiom
Microbiome & Chronic Diseases

Evidence Based Medicine

Osteoporosis {40000118}

Record Keys


Definition:
Osteoporosis
Class:[  ]

Details


Other Terms:[  ]
Authoring date:
2020-09-06

Links


Meta Information


ICD:[  ]
Category:
Musculoskeletal, Rheumatologic
MedDra ID:
10031282
MedDra Level:
4

Notes


- Warmth enhances bacterial polyamine biosynthesis, resulting in higher total polyamine levels in vivo. Spermine and spermidine supplementation increases bone strength, while inhibiting polyamine biosynthesis in vivo limits the beneficial warmth effects on the bone. (1)

Shared Notes


  • [1.4
    - A peptide from the von Willebrand factor type A domain protein (vWFA) was the most potent activator of Ro60-reactive T cells.
  • [1.5
    - Could reduce bone loss associated with estrogen deficiency in an ovariectomized (Ovx) mouse menopausal model.
    - Osteoclast bone resorption markers and activators (Trap5 and RANKL) as well as osteoclastogenesis are significantly decreased in L. reuteri-treated mice.
    - L. reuteri treatment may be a straightforward and cost-effective approach to reduce post-menopausal bone loss.

Common References