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- Warmth enhances bacterial polyamine biosynthesis, resulting in higher total polyamine levels in vivo. Spermine and spermidine supplementation increases bone strength, while inhibiting polyamine biosynthesis in vivo limits the beneficial warmth effects on the bone. (1)
- A peptide from the von Willebrand factor type A domain protein (vWFA) was the most potent activator of Ro60-reactive T cells.
- Could reduce bone loss associated with estrogen deficiency in an ovariectomized (Ovx) mouse menopausal model.
- Osteoclast bone resorption markers and activators (Trap5 and RANKL) as well as osteoclastogenesis are significantly decreased in L. reuteri-treated mice.
- L. reuteri treatment may be a straightforward and cost-effective approach to reduce post-menopausal bone loss.
- [1.1] Gut microbiota composition and bone mineral loss-epidemiologic evidence from individuals in Wuhan, China  
- [1.2] Gut microbiota alterations associated with reduced bone mineral density in older adults  
- [1.3] Diversity analysis of gut microbiota in osteoporosis and osteopenia patients  
- [1.4] T Cell Epitope Mimicry between Sjögren’s Syndrome Antigen A (SSA)/Ro60 and Oral, Gut, Skin and Vaginal Bacteria.  [Research] 
- [1.5] Probiotic L. reuteri treatment prevents bone loss in a menopausal ovariectomized mouse model  [Research]