MetaBiom
Microbiome & Chronic Diseases

Evidence Based Medicine

Obesity (Diet induced) ⇒ Obesity {40000117}

Record Keys


Definition:
Obesity (Diet induced)
Class:

Details


Other Terms:[  ]
Authoring date:
2020-09-06

Links


Meta Information


ICD:[  ]
Category:
Endocrinologic, DietNutrition
MedDra ID:[  ]
MedDra Level:[  ]

Notes


- Lactobacillus plantarum suppresses the production of leptin.(4)

Shared Notes


  • [1.1
    - SPF mice that received a high-fat diet did gain weight. This diet quickly boosted the abundance of certain microbes in the small intestine, including microbes from the Clostridiaceae and Peptostreptococcaceae families. A member of Clostridiaceae was found to specifically impact fat absorption. The abundance of other bacterial families decreased on a high-fat diet including Bifidobacteriacaea and Bacteriodacaea, which are commonly associated with leanness.
  • [1.2
    - Lactobacillus casei can improve insulin resistance which is the underlying cause of obesity-associated metabolic abnormalities, in diet-induced obesity (DIO) mice.
  • [1.3
    - These changes in Akkermansia muciniphila were robustly correlated with the expression of lipid metabolism and inflammation markers in adipose tissue, as well as several circulating parameters (i.e., glucose, insulin, triglycerides, leptin) from DIO mice.

Common References