MetaBiom
Microbiome & Chronic Diseases

Evidence Based Medicine

Food Allergy {40000112}

Record Keys


Definition:
Food Allergy
Class:[  ]

Details


Other Terms:[  ]
Authoring date:
2020-09-06

Links


Meta Information


ICD:[  ]
Category:
Dermatology, Immunologic
MedDra ID:[  ]
MedDra Level:[  ]

Notes


- These bacteria produce butyrate, a short-chain fatty acid that previous research has shown is a crucial nutrient for establishing a healthy microbial community in the gut. This suggests that this class of butyrate-producing bacteria provides more general protection against other common food allergies as well. (2)

- Therapy with Clostridiales species impacted by dysbiosis, either as a consortium or as monotherapy with Subdoligranulum variabile, suppressed FA in mice as did a separate immunomodulatory Bacteroidales consortium. (3)

Shared Notes


  • [1.1
    - Perhaps the trillions of microbes that live in us suppress immune responses to food by stimulating the TLR4 receptor. And perhaps perturbations in that teeming microbiome alter the suppression and cause a rise in allergies.
    - Clostridia, but not Bacteroides, prevented food-allergic responses when introduced into the guts of the squeaky-clean mice.
    - Mice colonized with Clostridia bacteria had more regulatory T cells, a type of cell that dampens immune responses. The Clostridia mice also produced more of a molecule called IL-22 that strengthens the intestinal lining. A new theory began to emerge: If protective microbes are missing, the gut barrier weakens, allowing food proteins to seep into the bloodstream and potentially trigger allergic responses.
    - Top food allergens (certain proteins found in milk, eggs, peanuts, tree nuts, soy, wheat, fish and shellfish) bear little biochemical resemblance to each other. What they do have in common is the ability to remain intact in the digestive tract
    -Clostridia, were enriched in stool samples from 3- to 6-month-old infants who eventually outgrew their allergy, compared to those who remained allergic.
    - Anaerostipes caccae appears to protect against allergic reactions when it is present in the gut.

Common References